Summary: GLEYA domain
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GLEYA domain Provide feedback
The GLEYA domain is related to lectin-like binding domains found in the S. cerevisiae Flo proteins and the C. glabrata Epa proteins [1]. It is a carbohydrate-binding domain that is found in fungal adhesins (also referred to as agglutinins or flocculins) [2]. Adhesins with a GLEYA domain possess a typical N-terminal signal peptide and a domain of conserved sequence repeats, but lack glycosylphosphatidylinositol (GPI) anchor attachment signals [3]. They contain a conserved motif G(M/L)(E/A/N/Q)YA, hence the name GLEYA. Based on sequence homology, it is suggested that the GLEYA domain would predominantly contain beta sheets [1]. The GLEYA domain is also found in S. pombe protein Q92344 thought to be a kinetochore portein (Sim4 complex subunit), however no direct evidence for kinetochore association has been found [4]. Furthermore, a global protein localisation study in S. pombe identified it as a secreted protein localized to the Golgi complex [5].
Literature references
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Linder T, Gustafsson CM; , Fungal Genet Biol. 2007; [Epub ahead of print]: Molecular phylogenetics of ascomycotal adhesins-A novel family of putative cell-surface adhesive proteins in fission yeasts. PUBMED:17870620 EPMC:17870620
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Andersson KM, Meerupati T, Levander F, Friman E, Ahren D, Tunlid A;, Appl Environ Microbiol. 2013;79:4993-5004.: Proteome of the nematode-trapping cells of the fungus Monacrosporium haptotylum. PUBMED:23770896 EPMC:23770896
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Liu MC, Yang CS, Yeh FL, Wei CH, Jane WN, Chung MC, Wang CS;, J Exp Bot. 2014;65:2023-2037.: A novel lily anther-specific gene encodes adhesin-like proteins associated with exine formation during anther development. PUBMED:24591055 EPMC:24591055
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Liu X, McLeod I, Anderson S, Yates JR 3rd, He X; , EMBO J. 2005;24:2919-2930.: Molecular analysis of kinetochore architecture in fission yeast. PUBMED:16079914 EPMC:16079914
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Sideri T, Rallis C, Bitton DA, Lages BM, Suo F, Rodriguez-Lopez M, Du LL, Bahler J;, G3 (Bethesda). 2014;5:145-155.: Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence. PUBMED:25452419 EPMC:25452419
Internal database links
SCOOP: | Glyco_hydro_3_C PA14 |
Similarity to PfamA using HHSearch: | PA14 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR018871
The GLEYA domain is related to lectin-like binding domains found in the Saccharomyces cerevisiae Flo proteins and the Candida glabrata Epa proteins [ PUBMED:17870620 ]. It is a carbohydrate-binding domain that is found in fungal adhesins (also referred to as agglutinins or flocculins) [ PUBMED:23770896 ]. Adhesins with a GLEYA domain possess a typical N-terminal signal peptide and a domain of conserved sequence repeats, but lack glycosylphosphatidylinositol (GPI) anchor attachment signals [ PUBMED:24591055 ]. They contain a conserved motif G(M/L)(E/A/N/Q)YA, hence the name GLEYA. Based on sequence homology, it is suggested that the GLEYA domain would predominantly contain beta sheets [ PUBMED:17870620 ]. The GLEYA domain is also found in Schizosaccharomyces pombe protein SWISSPROT , thought to be a kinetochore protein (Sim4 complex subunit), however no direct evidence for kinetochore association has been found [ PUBMED:16079914 ]. Furthermore, a global protein localisation study in S. pombe identified it as a secreted protein localized to the Golgi complex [ PUBMED:25452419 ].
Domain organisation
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Pfam Clan
Alignments
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (180) |
Full (930) |
Representative proteomes | UniProt (1778) |
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RP15 (80) |
RP35 (354) |
RP55 (676) |
RP75 (926) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (180) |
Full (930) |
Representative proteomes | UniProt (1778) |
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RP15 (80) |
RP35 (354) |
RP55 (676) |
RP75 (926) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
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Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Linder T |
Previous IDs: | PA14_2; |
Type: | Domain |
Sequence Ontology: | SO:0000417 |
Author: |
Linder T |
Number in seed: | 180 |
Number in full: | 930 |
Average length of the domain: | 93.9 aa |
Average identity of full alignment: | 25 % |
Average coverage of the sequence by the domain: | 11.42 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 91 | ||||||||||||
Family (HMM) version: | 12 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GLEYA domain has been found. There are 27 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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AlphaFold Structure Predictions
The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.
Protein | Predicted structure | External Information |
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A0A175VNJ8 | View 3D Structure | Click here |
P0CU04 | View 3D Structure | Click here |
P0CU05 | View 3D Structure | Click here |
Q7Z9I1 | View 3D Structure | Click here |
Q92344 | View 3D Structure | Click here |
Q9C0Y2 | View 3D Structure | Click here |