# STOCKHOLM 1.0
#=GF ID CX9C
#=GF AC PF16860.8
#=GF DE CHCH-CHCH-like Cx9C, IMS import disulfide relay-system,
#=GF AU Coggill P;0000-0001-5731-1588
#=GF GA 26.4 26.4
#=GF NC 26.3 26.3
#=GF TC 26.4 26.5
#=GF SE pdb_2lql
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0351
#=GF RN [1]
#=GF RM 22842048
#=GF RT Structural characterization of CHCHD5 and CHCHD7: two atypical
#=GF RT human twin CX9C proteins.
#=GF RA Banci L, Bertini I, Ciofi-Baffoni S, Jaiswal D, Neri S,
#=GF RA Peruzzini R, Winkelmann J;
#=GF RL J Struct Biol. 2012;180:190-200.
#=GF DR INTERPRO; IPR031731;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC CX9C is the first half of a twin Cx9C motif in eukaryotic
#=GF CC proteins. The function of this motif is to import
#=GF CC nuclear-encoded mitochondrial intermembrane-space-proteins into
#=GF CC the IMS (intermembrane space), as these latter lack a
#=GF CC mitochondrial targeting sequence. The Cx9C proteins have a
#=GF CC disulfide-bonded alpha-hairpin conformation. Cx9C-containing
#=GF CC proteins are thus putative substrates for the Mia40-dependent
#=GF CC thiol-disulfide exchange mechanism that carries out an oxidative
#=GF CC folding process resulting in the proteins being trapped in the
#=GF CC IMS [1].
#=GF SQ 122
Q5A1L3.1/14-57         LEDISRHCPHQFLSFHQCMTLP.QP..DPNQCFQQQVDLTKCIKTSV
A0A1E5RV90.1/13-56     MEDVSFNCPQQFMAYHKCISEN.HE..DPSKCAFRQQDLSNCIKTSV
A0A1E3P8Q1.1/11-53     -EDIARYCPQNFLNFHKCISQN.HA..NPQNCAPQQIELSKCIKSEV
Q04341.1/59-102        ---IMSECSEPMKKYDQCIRDNmGTrtINENCLGFLQDLRKCAELQV
A0A6P5A378.1/5-49      MELVAKFCHSELEAYGSCVQDNpQS..WPTKCAELKKKVSNCSSTHP
Q9BSY4.1/5-49          LEVTARYCGRELEQYGQCVAAKpES..WQRDCHYLKMSIAQCTSSHP
Q6CGT1.1/11-51         -EDVARYCPEQFLNYHKCLGAG.--..DVTKCFEEQEKLSTCVKTSV
Q6CGT1.1/57-95         ---ILKDCDSHLKAYENCLRAN.QN..SRSECFDKLQAMRKCSAN--
A0A261XZ99.1/5-49      LEQVAKNCALQLEMYQKCIDSHpDN..WSQACFRERRALTKCSEDNV
A0A261XZ99.1/53-93     -KFVKRHCGNSIDAYDKCLADH.AE..EPEKCMEPLKDLWLCTEA--
A0A4P9XPI9.1/8-49      ---VVKHCSEQLAAYSECVERNpLD..WNEKCEKQRKGLTLCAENNV
A0A4P9XPI9.1/55-92     ---VKEACAEAIAAYDTCVSQN.TT..DPEQCMDALRALHTCTE---
W1QJ36.1/9-52          LQDVAKYCPEQFVNYHKCVQSP.DK..KPIDCVPMQLALQQCVRNDV
A0A4Z2HZG7.1/5-49      MDITAKYCHTEMDAYGSCVASNpST..WQSKCHELKIKVAQCTSSHP
V8PAI1.1/22-66         LEITLRYCHKETEQYGRCVAANpSS..WQLDCHQLKLDMAKCTSSHP
A0A1E3PKT4.1/11-51     -EDVARYCPEKFLDYHRCMAAG.--..DSAKCLNEQVALTECVKTQV
A0A1E3PKT4.1/57-95     ---IVQDCGDKLKAYENCLREN.IK..DRSVCAPQLKSMRECSEK--
E7F5H1.1/5-49          MAITTKFCQKELEEYGGCVVSNpTS..WQEKCQELKLRVAHCTSSHP
Q9CQP3.1/5-49          LEVTARYCSRELDQYGQCVAAKpES..WHRDCHHLKMSIARCTSSHP
A0A402FQC5.1/80-124    LQVTARYCRKEMEEYGQCVATNpSS..WQQDCHQLKLDMAKCSSSHP
A0A4P9WEE5.1/5-49      LDEVAKHCHVQLSLYTRCVEENaGN..WEANCLLLKRALTKCAEENV
A0A4P9WEE5.1/55-91     ---VKQRCAEPIAAYQRCLADN.TS..DPSKCTAALKTLYECH----
F4P0J3.1/5-49          LDIVSKHCGLQVKLFGACLERNgGN..WESNCLKEKNQLTKCAEENV
A0A1D5PAN1.1/5-49      LEITARYCRNEMEQYGRCVAASpTS..WQTDCHSLRLSMSRCAATHP
A0A5E8C006.1/11-51     -EDVARFCPNYFLAYHQCLAKG.--..DASKCLKEQEQLSSCVRTEV
A0A5E8C006.1/59-96     -----SECAHHMKEYENCIKEN.TN..IRTKCFDQLQAVRQCSAKS-
B0BMY5.1/5-49          LEVTARYCSRELDQYGQCVAAKpES..WHRDCHYLKMSIARCTSSHP
A0A2G5BH59.1/5-49      LDEVNKHCGDHVEAYASCVDSHeDT..WRTDCAELRKALTKCTDKNV
A0A2G5BH59.1/52-92     MKMVRLNCQPMIDRYQSCLENN.KK..DPTVCMDTLRDLYQCTE---
A0A1Y1XV17.1/5-49      LDEVVKHCAVQLELYQRCIERNpES..WETDCRQQRQDLTKCSEDNV
A0A4P9ZWX6.1/6-49      -AQVVKHCGLQLQIYTDCVDAHkHD..WNAACFKQKQALTKCSEEHV
A0A4P9ZWX6.1/53-92     -KTVKQKCSTVISNYDKCVRDN.AD..DPEKCIQSLRDLYNCTQ---
A0A1E4TLY4.1/12-56     -EEVAKYCPDQFLNLHKCIGDGkAS.gKPVNCWNQQSQLSSCVKSKV
A0A1E4TLY4.1/62-100    ---IKTDCGEQFEAYKNCIKKD.PE..FKTTCFDQLQDLRECSAK--
A0A1Y2G982.1/11-52     ---VTKHCGLQLELYQRCVTHNpEN..WDIKCITQKRALAKCSEDNV
V9LAV4.1/5-49          LEVTAKHCAEEMEAYGQCVTSKpST..WQQDCHQLKMKVAECTSSHP
A0A1R1PSF9.1/5-47      LDLVSEHCANELNAYSDCVGQNpSD..WGSKCKELETKLTVCSEK--
A0A1R1PSF9.1/52-93     LQTVKTKCSTAILDYEGCIFMN.QS..NPESCIDQLKKLYDCTNS--
A0A1Y1Z4G8.1/5-49      LEEVVKYCGLQLEMYQRCVESNpTN..WESACFKQKQALTKCSEENV
A0A4W3GWB9.1/122-166   LEVTAKHCAEEMEAYGQCVTSKpST..WQQDCHQLKMKVAECTSSHP
A0A433PTG4.1/34-76     --EVVKHCALQLDMYQRCVESYpND..WDKQCLQQRRALTKCSDENV
A0A168L0T8.1/5-49      LEQVREKCALQLQMYQSCVENYpNT..WDKSCLQQKRALTKCSEENV
M2X117.1/5-48          LNAVSEKCGTEFRNFQHCVAENrEN..WEEVCRPQKAEFAKCTSEN-
M2X117.1/52-91         MDLVREGCFLEIRQYERCIKEN.RQ..EPTLCEEKRKRVLECG----
A0A0M0J2U1.1/5-46      LDQVAQHCLKELDAYSTCVEKHpHR..WQSVCATLKADLKDCAA---
A0A0M0J2U1.1/53-93     -NDVKARCAAEIEQYDRCLKAN.VN..HPDTCMPQLHRLWQCSEE--
A0A1U7LMC8.1/10-51     ---VLAKCASQVQTYNQCITDNpHN..WNKACLDERAAVTECAEEKV
A0A1U7LMC8.1/57-96     ---VKTDCASEIAAFNKCLEEN.SS..ELNSCIPVQRELYNCTAKS-
B3RP73.1/15-58         -NFAAQGCMSEVEAYADCVSKNrRT..WYKECKEHKFNLNKCTAESP
A0A2Z6S469.1/5-47      LEFVIKHCSTQLELYQRCIENNpND..WGSVCQKEKNELSKCSED--
A0A1D2VAX0.1/10-55     LEDIARNCPQEFLDYHKCVSQNhKN.gNASACVENQRKLTYCIKNNV
A0A2T0FCV2.1/13-49     ---VAEYCPAQFMNYYTCLSKG.--..DVTQCFDEQRALAACAKT--
A0A2T0FCV2.1/59-94     -----TNCKTQMDTYESCIRAN.PE..FKTQCFDKLTEMRECMT---
R7TFN8.1/7-49          --LVRRFCMQQMIDYMDCVDAHpTK..ADKRCQETKSALATCAQQHP
R7TFN8.1/52-91         -ESITKTCGQHFYDYEKCVQEH.PH..SMEKCVPSLEAFTKCAH---
A0A316ULE1.1/5-48      MERVAKQCGKELDTFQRCILAN.QT..SPSTCDPYKVALSQCAAQAV
A0A507FHF8.1/5-49      LETVEKHCGSQLSEYGKCIDDNqPN..FESPCLALKRALTQCAEVNV
A0A0L0FGK0.1/9-47      ----SAQCGEQMQAYEDCVVSNpNS..WSKDCAKLEENLSNCTDK--
A0A2N1JB65.1/5-48      MEAVGRNCGTELATFERCIVAN.KG..DASKCVEPQRALSQCAARAV
A0A0S2M663.1/7-50      --VVAANCATQMAKYQECVLKN.QAgdWNQICRPEGRALAACADAAV
A0A433U072.1/6-49      -RLVEQHCSKYLTMFGECVHQFpHT..WQMDCESERRKLARCAETNP
A0A0E9NIC6.1/5-49      LQEVAEKCANELFALQACVTSHpND..WDAACWRQRQALTKCSEDNV
A0A0D1E1A4.1/6-48      -DQVAAKCGKQLDTFQRCILAN.QQ..NPGACEQYKTELSRCAASAV
A0A1R0GW97.1/5-47      LEEVSKNCAVQINDFYSCVEENqTD..WKTKCSTLETSLAACSEQ--
A0A1R0GW97.1/57-92     -----NKCKDSVQKYENCVKNN.QT..NPETCISELKDLYNCTN---
F2U8P1.1/5-46          LDAVEASCRQEVEAFHKCAEVH.--..GNDGCPEQKAALQKCSDQSV
A0A2G8LKR9.1/1-41      ----MKYCSSELEDYAACVANYpQT..WNTDCEEQKLKAADCSSNSP
A0A7M7LPG1.1/8-49      ---VLKYCGKELEEYGNCVASYpEN..WQNKCKDLGEAASACSSTHP
R1BM12.1/5-42          -----RPCSPELERYAACVDGHsGT..WLVDCDPLKSQLNACASS--
A0A1Y1VHN0.1/6-48      -NEVAEKCKKQLKAFAKCVDKHpST..YDCDCKKQKEAVQKCSEEN-
A0A1Y1VHN0.1/54-92     --LINKHCKQQSVAYDNCVSNNkLN..PESKCLEQFRALYLCS----
A0A1R0GPY4.1/5-47      LEEVSKNCAVQINDFYSCVEESqTD..WKTKCSTLETSLAACSEQ--
A0A1R0GPY4.1/57-92     -----NKCKDSVQKYENCVKNN.QT..NPETCISELKDLYNCTN---
A0A4P9WZX8.1/6-48      -AQVTAKCRPAIDAYSECVQRNpST..WDVRCVAERQAVSQCADQN-
A0A177UWL5.1/5-49      LEAVSRHCSEQLMNYQRCLISNpANssSSSACDEPKKALTDCAAT--
A0A137P056.1/7-49      --QVQQKCAEQLKALGECIEKN.QS.dYNVKCVAQRQAVTTCAENNV
A0A4P9Y1K1.1/6-48      -DQVQKHCPAQLNAYTQCVEDHpGD..WETKCAEKRRLLRLCSEDN-
V4CRA9.1/8-49          ---AEQKCRRYYDGYRTCIERFpET..WHLDCTKEKDKFTKCAETHP
A0A316W4C6.1/7-49      --NVASSCADQLNSYQRCILANqSN..HGEACAEQKTALAICAADSV
A0A1Y2HZ05.1/6-47      -DEVQQHCGPELRQFQECLDK-.TS..HPSNCQRALKTLNLCTEAKV
A0A0L0S108.1/8-47      ---VQERCGPELAAFQNCLDK-.TT..HPKNCERARRAMNLCTDAKV
A0A6P7U2C2.1/5-49      MQVVLQQCGKYIQLYSTCVENYpET..WHIDCELSRMKLAKCAESNP
A0A0L0RWA9.1/8-47      ---VQENCGAELAAFQDCLDR-.TT..HPKNCERARRAMNLCTDAKV
A0A4Y2PJ56.1/5-49      MKIVNSHCSSLMERYTKCVENFpNV..WNTACSHQRHELARCSETHP
A0A2G5EFB2.1/18-57     ---IQKPCMKEMLQFLSCMALN.HN..NDDRCVRQKELLSTCMDSQ-
A0A058Z925.1/75-114    MNKVNAYCSDEFFRYWKCIDLN.NQ..SFRYCRQEQNVLDTCM----
A0A4Y2Q2B7.1/24-68     MKIVNSHCSSLMERYTKCVENFpNV..WNTACSHQRHELARCSETHP
A0A2G5FBV0.1/18-57     ---IQKPCMKEMLQFLSCMALN.HN..SDDRCVRQKELLRTCMDSQ-
A0A4P9Y1A1.1/1008-1049 -DQVQKHCPAQLNAYTQCVEDHpGD..WETKCAEKRRLLRLCSED--
A0A087TYD3.1/9-53      MQIVNSHCSTLMNNYSKCVDKYpNV..WYTACAYHRHELARCSETHP
A0A0K9PNT7.1/17-56     ---VDKPCTKELVSFLGCVALN.QD..DDKKCDKQKGLLQTCINEQ-
A0A384KMV1.1/19-56     ----AKPCMKEMVSFLNCMALN.NI..KDDKCEKQKQLLSVCMQG--
A8MRX3.1/19-56         ----AKPCMKEMVSFLNCMALN.NI..KDDKCEKQKQLLSVCMQG--
C6SWA1.1/19-56         ----QKPCMKEMALFLSCMAAN.HS..DTEACARQKELLNVCIDA--
C6T5H6.1/19-56         ----QKPCMKEMALFLSCMAAN.HS..DTDACARQKELLNVCIDA--
Q1G3Z3.1/30-67         ----AKPCMKEMVSFLNCMALN.NI..KDDKCEKQKQLLSVCMQG--
A0A5S9WMR1.1/84-121    ----AKPCMKEMVSFLNCMALN.NI..KDDKCEKQKQLLSVCMQG--
A0A6A4M2M8.1/110-149   ----QKPCMKEMITFLNCLALN.QN..NDEKCVRHKELLSVCMDGQV
A0A2R6S0X6.1/19-56     ----QKPCMKEMITFLNCLSLN.HN..SDEKCVRQKELLSACMDA--
A0A7G2DYW4.1/228-265   ----AKPCMKEMVSFLNCMALN.NI..KDDKCEKQKQLLSVCMQG--
A0A6A4KSS4.1/141-180   ----QKTCMKEMTTFLNCLALN.QN..NDEKCVQHKELLSMCMDGQV
A0A199V533.1/18-56     ---VGKPCMKEMVSFLGCLSLN.KS..NDDKCVRQKDLLLACVEA--
M0RPI7.1/20-56         -----KPCMKEMLSFLGCLSLN.KN..NDDKCVRQKDMLLTCVDA--
A0A2J6KHV8.1/19-57     ----SKPCMKDMITFLGCLSLN.HN..SDEKCTRQRQLLDTCLESQ-
A0A7J7L5A4.1/19-58     ---IRQPCMKEMISFLNCLSLN.QH..NAEKCGQMKDVLVSCMDNQ-
U5D728.1/20-56         -----KPCMKEMLSFLNCLSLN.QM..HDDKCVHQKELLSACMDA--
Q4UEN2.1/6-42          -----RKCSKDLNEYYKCLSGS.GR..DPSKCQTQEIALRKCSTT--
A0A2J6LZL8.1/75-113    ----SKPCMKDMITFLGCLSLN.HN..SDEKCTRQRQLLDTCLESQ-
A0A654GG15.1/32-73     ----KKNCAEQFTPYFQCIYKHgGHtfSIENCRKLQYPLDECIKTK-
Q10NA6.1/18-56         ---VTKPCMIEMVSFLNCLALN.KQ..NDDKCVRQKDLLVACAQA--
A0A4Y7LF75.1/19-57     ----SKPCMKEMMALLNCLATS.GN..NDDKCVKHKDLLRTCTDTQ-
Q7EYS1.1/19-56         ----AKPCMIEMVSFLNCLALN.KQ..NDDKCVRQKDLLVACTQA--
A0A5A8EBW1.1/37-74     ------PCFEQTEAFSSCLKHN.DF..EPVMCHKEKMALTACIDTKP
A0A4Y7KVE7.1/55-93     ----SKPCMKEMMALLNCLATS.GN..NDDKCVKHKDLLRTCTDTQ-
S8CL35.1/19-56         ----QKPCMKEMMSFLSCLALS.QG..GDERCSLQKTLLSACMDG--
A0A0G4IS46.1/24-61     --TAPKPCTSEMISFLNCITAN.NY..ENTRCKEEINLLSECT----
A0A2R6X6T0.1/20-55     -----RPCLSEMLNFLACLKKA.NF..NDDGCMQEKKALQTCMD---
A0A2Z7BLT4.1/19-56     ----QKPCMREMVSFLSCLSLS.QG..NDGKCSRQKSLLSACMDA--
A0A077ZQA8.1/42-78     -----KFCQADVKTFRNCMSLN.NY..DENKCLVTKGILDKCAAS--
A0A4V5ZYU1.1/74-117    LQSVKRTCADEFKAYGQCIDQG.SSklYVSKCREEQRFFDRCVED--
A0A397UEL4.1/10-45     -----EKCHDAINAFQTCLEKN.KD..DPEVCREKLKELYNCTE---
B3S415.1/38-76         ---VLQACHNEAIIYGKCVSQK.EN.lGHNNCLKEFNALAECAR---
//