# STOCKHOLM 1.0 #=GF ID Perilipin_2 #=GF AC PF17316.5 #=GF DE Perilipin protein #=GF AU Bateman A;0000-0002-6982-4660 #=GF GA 30.1 30.1 #=GF NC 30.0 30.0 #=GF TC 30.1 30.1 #=GF PI PET10; #=GF SE PRODOM:PD126435 #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF CL CL0718 #=GF RN [1] #=GF RM 24868093 #=GF RT High confidence proteomic analysis of yeast LDs identifies #=GF RT additional droplet proteins and reveals connections to dolichol #=GF RT synthesis and sterol acetylation. #=GF RA Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, #=GF RA Haas J, Walther TC, Farese RV Jr; #=GF RL J Lipid Res. 2014;55:1465-1477. #=GF RN [2] #=GF RM 28801319 #=GF RT Pet10p is a yeast perilipin that stabilizes lipid droplets and #=GF RT promotes their assembly. #=GF RA Gao Q, Binns DD, Kinch LN, Grishin NV, Ortiz N, Chen X, Goodman #=GF RA JM; #=GF RL J Cell Biol. 2017;216:3199-3217. #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This family includes Pet10p and Sps4p which are yeast perilipin #=GF CC proteins [1]. #=GF SQ 41 P09937.2/65-316 KTVDHIETYPIVQETEEIAKKIALTRIILAQTKPRI.DKVVV......SRP.VQAVAPVVNFFDKMANST.LSTVERVVP..SLK..TKTYKRLGE.E.IALPYT......LSKKYGKQLRDT.TARNGDNYVYQPVHGRLMKFRKYYNEKFID..TKGKPLIRGQLDPVLLPVNNTFEKVTVKYLPK.GKK.........VPN-DS........FSCEFNRGLALE..YNFMTR.AVSAVSH..QVVGIAK..........................LPIAYGYHTNSVYNKNLDKQAD....lKM..KNVLRGTWDTITDLEREIWASVT A0A1E5REP4.1/48-299 KTLDHLYSYPLVQQTTEFVGDIPAVRILNANLLPLI.DNKLV......AKA.FTVVKPCTTLVDNMGEKS.LQIVDKVVP..SLK..EKTYQKLGE.E.VAYPYT......YTKETVQKGTQL.ASTYATEYCYEPVHSRILGFRKFYNEKLYD..TKGKXLIRGSLDPFVGPINGKLEQYAEQYLPK.GNK.........VST-DG........FSNEVDRSFAIV..WNALGR.LIPATEQ..KVGDIVT..........................APCQYTKHVCETFNHNLDQEKD....lGL..KNSFNASKKSVQELEKEIVDSVK A0A1E3P261.1/2-250 -TTEHLKSYPIINETSTFVNEFAITKAAINSSIPII.KPIAE.....fIHS.QSLLKPIVQTVDNFGNST.LNSVESVAP..CLK..TATWEDVLV.S.IKTPIV......QTDEAIKDAFTA.TGDCMENNLIAPTRRFVRNGRAYYNEKLYD..TKGKPLLRSSLDPVFRPVNYHMENFTLTNLPE.GEP.........VMV--E........YSSEVERNVYLS..MNLIER.AIPVMGN..KVVECLM..........................VPCNYTIHVFDVYNDNLDKIEP.....SF..NSSIKATYNTSVDLTNEAISET- Q6C0J3.1/47-304 KFIQHLSEYPAVAAVTGFAASFPVVKIFASNAVPLI.QAIQNrgapvaEPV.VKRAAPYISQIDNAADEA.LNRLDKAVP..SLK..NTKPDEVYSrI.VTQPLE......NVRGTVDKYADE.TKNTVSRVVVQPIRDVASRVQSQVVT-YYD..AHGKPIVHARLDPIFHPLNDRLEALINAYLPK.GQE.........IVT--D........AENELARAWRLT..VVAFDR.ARPLIEQ..QTSQIQE..........................INQHTREHIQKVYDGKRSEIDDk...kTV..SGPVYATVATVRDLSQEGLQYAQ A0A1E3QDH8.1/30-295 -FVAHLRSYPIVDATVSYTTSLPLVKKASATAKPYV.DKYVH......-PA.VEKAAPVLSRVDKLGDTT.LSKVDKYVP..ALR..TTAAPDIPG.T.VSKSVE......SVKSTTHLYTEA.ARTKVNDTVVEPTKQAVDKA-KQRTAALYD..AKGRPFVRAKLDPVLAPLNSRLIALLDAYLPP.AKSy.......aDGTAAEg.....iaATTELGRLYLIG..TDAVYR.VKPVIED..RVAATRAhgket...............vdyflsVPSAARSHVISVWEDKKSKTDIk..skPI..TGPLYVSLSTGKHLVFEVVSF-- P36139.3/19-266 -TWSHLQRYPALSKFIKYAESLPPVERLISFNLVVL.GSVNQwv.sesSSS.PRLVKQVVAAGKEGAFKL.DELVNLLVF..KEG..VDGLLYNWKsH.SNTPGI......WLVWFFVDYVANiSNTLLREFLIKPLHLQGSTASKEIGSSGEE..NKVTD---ASSLPHVAELSSTTRGMSQEIQSKvKSNy.......iDPTKDL........AKEKYDAIVKPT..TDKLQSvYIDPTKT..KLN----..........................---ETYQRFTTVYENNLSKSES.....--..--VPKAIVSTGLDLGNATIEKLK W1QF93.1/11-244 KTYARVQTYPIAASWIRIGGHFPLPHVL----RPRL.YALAY......---.SPAFKDYTEVLDSYFDHW.LEDVENTVP..EIK..TLRMRDIRD.S.LTRPVV......DASLFVDRNMHA.LSVAMNQRVLEPARKTAGDIRKAYAP-MYD..TQGRALLRSQLDPVFKPLNERLARLV------.GDD.........AET--E........YSSELSHSLRLL..NGVAEQ.TRPRIAN..SVVRGRQ..........................LPSQVTSHLNEVYQTNKSKRGE.....GR..LIVMIASMDTVRDLLNEGYNV-- A0A167FRT0.1/33-290 -FVQHLATYPAVAALTGFVASAPLVGMFASNAIPLM.MAIRDrsrpiaDPV.VKRASPVIVRVDKFGDSI.LTTVDHTFP..AIT..QTRPEEVIE.Y.AKAPVN......QAREAYTSYSNS.TRGLVEHRVIDPIKKVSQAVRVQYNK-VYD..TKGKALVRSNLDSLVLPINDRLENVITDYLPE.GEE.........LPQADG........LSNEISRTWRLV..RVAVHR.GRPVLAE..QVNQVVT..........................LPRIATEHVFNTWEEKVQKHSN....gKPtaTTYALAYLGTTRQLSSDSISAV- A0A1D8PU41.1/73-262 PTFQHLKHYPLVNSTKSAIELIPLSKSVFSIMGNSF.SFVRS......---.YQPMKYIVGRSDTLTNRA.LDEIDKWLP..SLQ..TVEVQDITT.P.ITKPVN......DTVETVQNTITA.VNGSVNKNFVDPTKSALGSVKEEFQNHVYD..AEGKGIISSQADPMVAPLNHTLEQFVDNHFPN.TKK.........VPT-EG........HASEISRTFKIV..GNLISR.GEK----..-------..........................----------------------.....--..----------------------- A0A5E8BCV8.1/29-293 -FFTHLYSYPAVNAAVDYATHIPVVQRLSTSARPYL.DSLKErs.kpiSEPvVKRATPVLAKADVFGDKI.LSRVDENFP..LLK..TTTPADAVD.L.ARKPYE......TVKSTAEAYSTA.AHDRLSTSVVEPLKKAGERVKEHYTT-VYD..SKSST-IKSQVDPLIHPLNDRFEFLIKHFFPEsS-Vs.......lQQEEDQqqapsekfVSAEVARTVYLA..HVALQQ.ARPLLDV..QASHLKT..........................LPEVTRKHILHVYDEKLTAYGK....dKI.vTGPVYASVATFKQLSGEGVVY-- A0A1E4TEV6.1/5-80 -FLAHVYSYPVVASTTEKIIAMGPVKDAIAKTSPII.DAIAAr....tAPF.VQPVKPLLAKADKLGDSS.LTKLDSFYP..SVK..A--------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A1E4TEV6.1/96-209 ------------------------------------.-----......---.------------------.---------..---..---------.-.------......------------.------------------------------..------VDGKVAPVIKPLNDSFEGIVTKYLPKeGAG.........QLTV-E........SSTETYRTYLII..LEAIKR.IIPFLYS..SAEFAQK..........................KGTEVSAHVKEVYGSKLNEPKE....kSF..TAPVYASVATGVDVAGEVVTAV- I2JVZ1.2/44-266 -LYAHLKTYPIANSWIRIAHWVSMPRVI----RPYL.YQLAF......---.SGPVKEYTIMVDNFVDEQvLGSLDNAVP..QVK..TLRMRDIRD.F.LTGPFT......RTYELTRGILSN.SLSTTDRMALEPARLRIHETRTXLRNRVNEmsSRTRPVVLSRVNPXVKPLNKDLAKYINQXDPKnPID.........NKILEX........QDNELLNTVKIM..NEGLDR.TRSIAST..XLXQLRI..........................IPANASKRISEVYHESQXKRGD.....--..----------------------- A0A2T0FK93.1/20-259 -FVQHLATYPAITAVAGLVASFPVVKIFASNAVPLI.QAVHErt.rkvSDPlVSAVEPALKRADELGDKV.LTDLDNRFP..ALK..TVQPADL--.-.----VE......GAQSRINSARAS.AQSAVDAHLIQPVANVAGAAKAQYTK-VYD..TQGQYI-ATIVNNQVGPVNVRLESVISEYLPS.DQA.........LPPKE-........-GTEVQRTFVLV..KTAAER.ARPQIQE..FEV----..........................---STRQYCVQVYQAKLKERDGekethSL..ISSLLAAVAAGRQITGEGL---- A0A1E3PCQ2.1/27-248 -TLTHLNNYPLLNEISSFFLSFYIISYFATLVSKIS.LDFKNe...ilLKY.FKFSIDWIDYFDKLFDIYiLGNIDHFLP..ILG..KIHLKDLYP.S.NIYNVT......--INE-------.IKLYYQFSIA------------KIDE-FKE..NQLKPTIISNTNPIIAPINSKLSTTIDNYLPS.DNSi......epSPV-SS........SSSELSKFSNLL..TLAYQR.SKPLILG..KFQNVKQ..........................----YPTKIQSIYNDELNKNDQ.....--..-NITKAITNTSIEISNK------ A0A1E3PHG0.1/22-236 KFLSHLNAYPTLGALAGYAGSFPLVKALADHSVPIL.VSLGQ......-TT.KPLSHPLLSRIDRLGDNL.LTQVDATFP..VFK..ETTPQDVME.V.AKRPLE......TIKSTTTMYKSA.ARNSIDQYVIDPVKSLTVS-----TASTLD..STTSPF----LNPLLSPVNVRLQALAKDYHLVdYASva....assQDSETT........ESSELSQLSQPSelTKTYNL.SLQVFKH..LRPNTTA..........................IASSAKSHVNER----------.....--..----------------------- A0A1D2VNH6.1/23-271 KSLDHLKTYPIFNELVNYLTSLSFVAYLSSFL-SSF.EVKDKl....dNVS.KKIPSNYKGFLVTYISQF.DQIFNDFVL..EKG..LDSNFPNLK.S.LNS--D......DLKNVKPSLVLNdFVTYLKNLFNK----SVNDV------KTYK..DKEKKNVLKKVNPVVSPVNDKLESFINSYLPSdNNEegtalkkrnVTTNEKts...ineDDDEVLRMYALA..SSAYQK.VKPIASA..KSQELSQ..........................VPRKLSDHINNVYAENLKISEN.....--..-SKSKAIKLTGTDLSNEF----- I2JVJ7.1/32-132 KAVSHISAYPLVSESLXYVLGFQVXALIXGYVLAAV.XRAAGl....iS-S.IPGLVQIFNLFDQTFDSV.LSALDSRFP..RLA..KLSFSDXAG.F.VTSVLQ......RVVDFVKVYA--.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- I2JVJ7.1/122-240 ------------------------------------.-----......---.------------------.---------..---..---------.-.------......------------.--------------QRVVDFVKVYAGALYX..-RTKPY----VDPAAKRVNDLYEXALNEAIPXrSSD.........XEXXKD........TSDELGRSYILA..KETYHR.VEPY-TR..QVR----..........................---AIPSHVGSVYQDEKSKAAS.....--..--TQEAITKTTARVSKEAYETI- W1QJZ1.1/16-121 -TYSHVFKYPLVAEASALAERSSAVRVVESYAHSLL.SRALS.....vLSS.VSILVSLLNAIDQTTDAT.LSYLDSTFP..FLT..TISTESISK.TfNGYYDR......WARGVVKNARATfAN----------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- W1QJZ1.1/117-227 ------------------------------------.-----......---.------------------.---------..---..---------.-.------......------------.---------------------------ATF..ANTTSSVRSRLSAVVKTFNDYYESAVDRLLPL.KNQae....akgQEVTDI........AQSELTRSRKLL..RSTYER.ALPYVHQ..VSG----..........................----LPQYVTEVYNSEKASSSA.....--..---PAAIAKTSRRLSNEAY---- A0A1D2VL43.1/95-184 ------------------------------------.-----......---.------------------.---------..---..---------.-.------......------------.------EKMLRPAKAVVATAREQLNSRVYD..SHGKAIIRSNLDPILKPINDNLNDNIKKLNID.IEP.........VPK-KG........YSNELSRTTRLI..SRSTSS.SINQLLS..K------..........................----------------------.....--..----------------------- G4MRE1.1/15-99 -FFDHLAQYPVVNDGIEVFKKNPYGQRSINVTDMVY.TRVAKpvipylSRP.YQYVSPYVKRVDDIGDKT.LSRVDKTFP..AVK..KPTADL---.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- D5GI38.1/82-158 KSLSHLKSYPIVNDSISVFENHPLGQRSISLSQSCY.STFLAp....iTPY.LSRAAPYVSRADEFADSN.LGKIDSYFP..ILK..E--------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A3N4I642.1/14-95 KSINHITSYPVVSDTLSYAQTFAIVQQAVTATQRAT.GLLQPfa.pllEKA.NNIAAPVVNKVDDFAESK.LGQLDEKVP..FVK..KPT------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- C4QVF8.1/23-119 KTVHHLSQYPLLKQAWEYVVGFAWVGWVWTNVIQLY.TILRVn....vVDR.VPFVASLLNALDSSFEYLvLQTTDRVLP..FLT..ELTYQDLIS.I.PVKNYE......LLSK--------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A0D2A6Z9.1/15-96 -FLSHLTSYPLVSDSITVVKENPYGAKSIDFTNASY.TKFVKpnlsyfQTP.AAYAKPYVVKADELGDKF.LSKFDEKVP..IVK..TET------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- C8V4B0.1/23-103 -FLEHLTSYPVVSDSISFYKGNKYGAKSLEFADQGY.GFAKPyl.sylSKP.YGYVAPYVTRADSLGDKG.LQKVDATFP..IIK..EDT------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A6G1GEH1.1/24-101 -FLSHLQSYPVVSDSFSTYKSHPWGAKSVDLASSTYeKSWPY.....lQGP.FRYIAPYVSQIDQLADHG.LTRVDSTFP..QVK..TPT------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A1Z5TIM2.1/23-129 KFLSHVTSYPMVNDGIETFKQHPVGKKSLEIADGAY.QRVGKpvepylQQG.FNYVKPYYERADEMADSG.LGHVDHRFP..IVKedTHTVIDTAKsY.AFWPYN......YVWSTWND----.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A1Z5TUV7.1/23-129 KFLSHVTSYPMVNDGIETFKQHPVGKKSLEIADGAY.QRVGKpvepylQQG.FNYVKPYYERADEMADSG.LGHVDHRFP..IVKedTHTVIDTAKsY.AFWPYN......YVWSTWND----.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- U7Q528.1/15-97 -FLEHLLQYPLVSDSVSTVKENKYGQQTLALSTSAY.ETLAKpvlpylSKP.YGYVSPYVKKADSLGDRT.LDSLDQRFP..VVR..KPTA-----.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A6H0XW41.1/448-558 KTISHLASYPAVSDSIDTFKSHPYGKKSLEMANDAY.TRFAKpvepylETP.YSYAKPYVSKADEFGDRA.LSSVDGHFPivKEK..TDTIIEKAKsT.AFWPYT......YLNETWSDEYNK.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A0S6XJ39.1/24-106 -FLSHLTSYPVVSDGIETFKANALGAKSIEIVDATY.TRVGKplephlRTP.YSYAKPYVNKADSLADQA.LNSVDSHFP..IVK..EDTN-----.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- C4R9C3.1/68-174 KVYQHLRDYPIARSYFDNVNRVPQPRFV----RTVI.HDALF......---.SETLVPYTVRLDTSLNNL.LDQLDQRAP..QLK..VLRMRDIRD.V.LAGPFA......--RAYASFASRTsSPEKISDVIVEPT-----------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- R8BW69.1/19-100 -SLQHLLDYPVVHDGVETFKSNPYGQKSLQLSDSAY.KTFAApvvpyfQKP.YQYVSPYVKKADDLGDKA.LAKVDSKFP..VVK..KQT------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A545A7N6.1/24-105 -FLSHLKSYPVISDSITTIKSNRYGAKSLSLTTSSY.EKIAKpllpyfRTP.IDYISPYAAKADSIGKSA.LSSFDSRFP..AVK..KPT------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A0G2GGZ6.1/21-111 KTLSHITSYPLVADSISTFKSNPYGAKSIEVADAGY.SKLVAptlpyfKKP.YSFVSPYVTKADELGDNT.LGKIDSKFP..VVKseTKELKDTAV.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A0D1XSD3.1/29-130 -FISHLTSYPLVSDSLSLYLENPYGAKSVNLFNEAY.KKFLTpvepylKTP.YSYIAPYLEKADSLGDKG.LSEVDSRFP..IVK..EETSSLKER.I.KNLPYVpystlvS-----------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- D4AMG8.1/16-92 -FLSHLISYPFIADYLETLKKSPYGQKSIEYADKSI.AQLQPyf.pylAKP.YGYVAPYVEKVDHLGNEG.LNQVDNTYP..KL-..---------.-.------......------------.------------------------------..--------------------------------.---.........------........------------..------.-------..-------..........................----------------------.....--..----------------------- A0A1U7LM99.1/22-281 -VLSRLQTYPLVQDSYRVFNSYTLGKKATDTVKSIS.EAAKPyl..dkTKPlLERAEPYLLKADAIACAR.LHDAEQRWP..IIK..APS-HEIYE.K.TTNPLA......QPLATVKATVNV.YTDAAKKNVC------------ER-----K..QKYDPLIKKRIDPYANPFIDRLENVITHYITGlDAP........pSQKPEF........HGNSIDRMLLIA..NSTYNV.LKPRVMEfpKVFDFRTgnwtkgetykttiysplgnlykfittQAHDEKDHVIKTFNEQKNEDSY.....--..KGQLHAALNTAKIVSGE------ //