# STOCKHOLM 1.0 #=GF ID AgI_II_C2 #=GF AC PF17998.4 #=GF DE Cell surface antigen I/II C2 terminal domain #=GF AU El-Gebali S;0000-0003-1378-5495 #=GF GA 27.1 27.1 #=GF NC 26.8 26.2 #=GF TC 27.2 27.1 #=GF SE ECOD:EUF00480 #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF CL CL0204 #=GF RN [1] #=GF RM 24918040 #=GF RT Structure of the C-terminal domain of AspA (antigen I/II-family) #=GF RT protein from Streptococcus pyogenes. #=GF RA Hall M, Nylander S, Jenkinson HF, Persson K; #=GF RL FEBS Open Bio. 2014;4:283-289. #=GF DR INTERPRO; IPR026345; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This is the second domain (C2) located in the C-terminal region #=GF CC found in antigen I/II type adhesin protein AspA from S. #=GF CC pyogenes. Together with C3, these two domains form an elongated #=GF CC structure, each domain adopts the DEv-IgG fold. Similar to the #=GF CC classical IgG folds, it is comprised of two major antiparallel #=GF CC beta-sheets, designated ABED and CFG. For the C2-domain, there #=GF CC are two additional strands on the CFG sheet. Furthermore, sheets #=GF CC ABED and CFG are interconnected by several cross-connecting #=GF CC loops and one alpha-helix (DH1). The side chains of D982 and #=GF CC N996 in the C2-domain are involved in hydrogen bonding with the #=GF CC side chains of R1264 and N1295 in the C3 domain. Main chain #=GF CC hydrogen bonding can also be observed between S992 in C2 and #=GF CC N1189/G1191 in C3, furthermore stabilizing the interaction #=GF CC between the domains. The C2 domain contains one bound metal ion, #=GF CC modeled as Ca2+, and both the C2- and C3-domains are stabilized #=GF CC by conserved isopeptide bonds, which connect the beta-sheets of #=GF CC the central DEv-IgG motifs [1].Other members of this family #=GF CC include Major cell-surface adhesin PAc from Streptococcus mutans #=GF CC and SspB from Streptococcus gordonii. #=GF SQ 40 A0A347WMN8.1/883-1051 PDKNNEN.....ADGVLINDTVVALGTTNHYRLIWDLDQYKGDR.SAKETIAR..GFFFVDDYPEEVLDVVENGMA-..................ITTLDGQKV.SG-ITV..-----------KNYASLNEAPKDlqdkla...rakisptG.aFQVFLPDDNQAFYDQYVQ.TGTSLALLTKMTVK...DSL..yGQTKTYTNKAYQVD.FGNGYETKEV A0A347WMN8.1/1060-1228 PKKQNLN.....KDKVDINGKPMLVGTQNHYTLSWDLDQYRGIK.ADNSQIAQ..GFYFVDDYPEEALLPDEAAIQF..................IT-SDGKTV.SG-ITV..-----------KAYSQLSEAPKMlqaals...kqkiqpkG.aFQVFMPEDPQAFFESYVT.KGENITIVTPMTVL...ETM..lNSGKSYENVAYQVD.FGQAYETNTV A0A347WMN8.1/1237-1405 PHKSNTN.....QEGISIDGKTVLPNTVNYYKIVLDYSQYKDMV.VTDDVLAK..GFYMVDDYPEEALTLIPDGIQV..................LD-KDGNRV.SG-ISV..-----------STYASLSEAPKVvqdama...krqftpkG.aIQVLSSDDPKTFYETYVR.TGQTLVVTLPMTVK...NEL..tKTGGQYENTAYQID.FGLAYVTETV A0A0F4KNY2.1/338-485 PAKPIKDv...iENGQSINGKLVIPHEKFEYTVSQKVGIMGQ--.---DMLTKyrQFEISDPLPKEVTYLDSAYV--..................VDDSTGKRLdANAGAF..TYKNGILTFKFS-----------................-..--------YNYLKNIMAY.EGETYTVHIPVQVK...GNVklsSKLKSIDNDASTVI.NGRQRNTNKV A0A0F4KNY2.1/697-852 PIKSVVD.....TNNFDINHKLVKDGDIIYYHVDQKVGNLGTN-.LLKKYR--..SFKLSDKLDVN-LKYQDSY--V..................INKETGKRI.TDTNTTqyDPKTRTVTWEAS--KDFLEN---................-..GMKYKGEIYELVIKAKVD.TTETINNTIGDSNI...NNV...DGRISIKNIGQSII.NGNSRKTNE- A0A0F4KNY2.1/865-1010 PIKNVVD.....KDDGDINHKVVSNGDILYYHIDQHVGTLGK--.---DLISRykKFSILDKLDGDLDFVKAYLV--..................-N-KTTKEVlSDPSEVtfDEATNLVTWTAS-----------................-..---------DEFLKSMPL.KGETYELIIEAKVN..iKDPnqnKTKDSIKNTATANI.DDNPQITNEV A0A0F4KNY2.1/1021-1165 PEKTVLN.....NDNKDINHKTVVNGQQLIYHVSKKVGTLGF-G.LAQRYKEF..--TIIDKLDKN-VQFDSAYVQ-..................-NADTKAKV.SNPSEVsyDKDSNTVKFTAS-----------................-..---------NQFLSQMPL.KGETYDFVITVTVNiqdEDL...DKEVEIDNVGSVSL.DNQPQDTNTV A0A0F4KNY2.1/1177-1320 PTKSVVN.....HDGKDINHQIVSDGDTIYYHVDKKVGTLNQ-D.LAQRYKEF..--SMTDKLDHNLTFIKAYV---..................INKETGKTV.SQPAEI..TVSDNTVTWKAS-----------................-..---------ANFLKSMPL.KGETYELVIEAKVN..vSDKassTDEVTIENIASVSI.DNQPQQTNAV A0A0F4KNY2.1/1333-1467 PTKKVVN.....KDGKDINNTTVKVGDTLYYHVDQKVGTLGK--.---DLSERypQFTIKDQLDQRLTYVNAYVV--..................-NKADGKKM.SNDSEIsfDESSNTVLFTAS-----------................-..---------PDFLKAMPL.KGETYELVIEVKVN...KGA...---ATIANAETRSD.KSGNTA---- Q8G499.1/869-1007 -------.....GDQSSIDTKTVFPGQTVEYTVRVDPQIPAD--.QAYSVTAI..--KLSDTY-SEYTTANKQTLEI..................TDLGTGGIIpKSAYKVqwDEANHSFEATFA-----------................-..-------KDWVAANWKAG.SNPRVLLRFEAKVN...EDA...PTDKTVDNKAALTV.NNGVTPSNKV Q8G499.1/1016-1192 PSKQDTQ....kDPTISIDGKTALLGDKVYYRVNIDASRLTD--.TAYKVWRL..--GMTDDYDQEYLTLDAKHVEI..................LD-ETGRDR.TGEFNI..QDKDGVLYAFAKTVDTQIPATGEtvpgdpqpddlkayseK.tDKDYDPLKDPSIDQSLL-.-GHTYQVVMPMTVT...KVK...DGHT-VENTATQVT.NDKRDKTNTV A0A087CM51.1/697-835 -------.....GDQSSVDGKTVFPGQKVEYKLETTPKLPAN--.LAYQVTNV..--GVTDSYDQ-YLNVDKQTLEV..................TDLNTGNIIpKSQYTStwDDSAHTVRLAFS-----------................-..-------DAWVKANWKAG.SNPRIIVRFEGTVS...ADA...PANTKVDNQWKLTL.NNSITPSNIV A0A087CM51.1/844-1017 PSKQDTQ....kDAKINIDGMAAVLGDRIFYRVNLDASKLDN--.TAYVVQRL..--GMVDDYDEQYLKLDTTGIQV..................LD-AQGSDV.TGKFNI..QEKDGIVYAFFKTVDTTIPATGEtvlgdp....qssdlkAysTEKLDPLTSPAIDQKVL-.-GQTYKIVLPMTVK...AVK...DGYT-VKNTAIQVT.DNEQKLTNTV P17953.1/579-736 PNKEVTD.....-GQKNINDLNVKRGDSLQYIVTGDTTELAKVD.-PKTVTKQ..--GIRDTFDAEKVTIDLSKVKVyqadaslnekdlkavaaaINSGKAKDV.TASYDL..HLDQNTVTAMMK-----------................-..--------TNADDSVVLA.MGYKYLLVLPFVVK...---...NVEGDFENTAVQLT.NDGETVTNTV P17953.1/911-1056 PTKAVHN.....KKGEDINHGKVARGDVLSYEMTWDLKGYDK-D.FAFDTVDLatGVSFFDDYDETKVTPIKDLLR-..................VKDSKGEDI.TNQFTIswDDAKGTVTISAK-----------................-..-------DPQAFILAHG-.-GQELRVTLPTKVK...ANV...--SGDVYNLAEQNT.FGQRIKTNTV Q82YN1.1/588-745 PNKEVTD.....-GQKNINDLNVKRGDSLQYIVTGDTTELAKVD.-PKTVTKQ..--GIRDTFDAEKVTIDLSKVKVyqadaslnekdlkavaaaINSGKAKDV.TASYDL..NLDQNTVTAMMK-----------................-..--------TNADGSVVLA.MGYKYLLVLPFVVK...---...NVEGDFENTAVQLT.NDGETVTNTV Q82YN1.1/920-1065 PTKAVHN.....KKGEDINHGKVARGDVLSYEMTWDLKGYDK-D.FAFDTVDLatGVSFFDDYDETKVTPIKDLLR-..................VKDSKGVDI.TNQFTIswDDAKGTVTISAK-----------................-..-------DPQAFILAYG-.-GQELRVTLPTKVK...ADV...--SGDVYNSAEQNT.FGQRIKTNTV Q838H0.1/588-745 PNKEVTD.....-GQKNVNDLNVKRGDSLQYIVTGDTTELAKVD.-PKTVTKQ..--GIRDTFDAEKVTIDLSKVKVyqadaslnekdskavaaaINSGRAKDV.TASYDL..HLDQNTVTAMMK-----------................-..--------TNADGSIVLA.MGYKYLLVLPFVVK...---...NVEGDFENTAVQLT.NDGETVTNTV Q838H0.1/920-1065 PTKAVHN.....KKGEDINHGKVARGDVLSYEMTWDLKGYDK-D.FAFDTVDLatGVSFFDDYDETKVTPIKDLLR-..................VKDSKGVDI.TNQFTIswDDAKGTVTISAK-----------................-..-------DPQAFILAHG-.-GQELRVTLPTKVK...ADV...--SGDIYNSAEQNT.FGQRIKTNTV Q839L6.1/590-747 PNKEVTD.....-GQKNINDLNVKRGDSLQYIVTGDTTELAKVD.-PKTVTKQ..--GIRDTFDAEKVTIDLSKVKVyqadaslnekdlkavaaaINSGKAIDV.TASYVL..NLDQNTVTAMMK-----------................-..--------TNADGSVVLA.MGYKYLLVLPFVVK...---...NVEGDFENTAVQLT.NDGETVTNTV Q839L6.1/922-1067 PTKAVHN.....KKGEDINHGKVARGDVLSYEMTWDLKGYDK-D.FAFDTVDLatGVSFFDDYDETKVTPIKDLLR-..................VKDSKGADI.TNQFTIswDDAKGTVTISAK-----------................-..-------DPQAFILAYG-.-GQELRVTLPTKVK...ANV...--SGDVYNSAEQNT.FGQRIKTNTV A0A087C1X0.1/530-668 -------.....GDQSSVDGKTVFPGQKVEYKLETTPKLPAN--.LAYQVTNV..--GVTDSYDQ-YLNVDKQTLEV..................TDLNTGNIIpKSQYTStwNDGEHNVRLVFD-----------................-..-------AAWVKANWKAG.SNPRIIVRFEGTVS...ADA...PANTKVDNQWKLTL.NNSITPSNIV A0A087C1X0.1/677-850 PSKQDTQ....kDAKINIDGTTAVLGDRIYYRVNLDASKLDN--.TAYVVQRL..--GMVDDYDEQYLKLDTTAIQV..................LD-AQGSDV.TGKFNI..QDKDGVLYAFFKTVDTTIPATREtvkgdp....qpsdlkAysTAKPDPLTSPAIDQKVL-.-GQTYQIVLPMTVK...AVK...DGYT-VKNTAIQVT.NNEQKLTNTV S2W3L5.1/653-798 ------AsasqgGDQSNIHQLGVWPGQIIEYKVDVDLNLPNGMArGDDSVQSL..--AVEDAYDPM-FVPNKKSVEF..................YDVRNNKVIpRSAYKLefNDAEHKFTATFK-----------................-..-------EDWVKKNVKRE.NNGWLILRFDGRVK...DDT..mPGSV-VKNQAFEIL.NGARASTN-- S2W3L5.1/809-980 PHKEDLN.....TNNVDINGKTVIQGDVLRYRLTLDGGMPRE-K.LAYDVHKF..--GMIDDFDEEYLDVAPENIK-..................VTTLDGADV.TDKFNT..QVRDGKFYVFAKHVDHTNNAGELikgvq.....penlaeY.vNKAIDPINDPIIDQALL-.-GKKYYVIADATVK...KEK...DGYV-IKNTAWQNT.ENSLIQTEIV A0A087VVC3.1/586-723 -------.....-TQGSVDGKIVHPGQRLEYQLDSQPSLPAS--.LAYPVKEI..--TFTDTYDQ-WFRPDKQTLEM..................MDLAKGRPIpKSGYSThwDDRLHLVRVSLK-----------................-..-------DAGLIGQWRAS.GNPRVQLRFEGVVD...KAA...PTDHRVDNQWVLTI.NNSLTPSNRV A0A087VVC3.1/732-906 PVKRVVSs...rDQTVNIDGRTLLQGDTGVYRITMDVSQ---SD.LAYKVWRL..--GLVDDFDDEHLSIDPGHIRV..................MG-SDGQDY.TARFNI..QIQGGVVYAFARTVDTFIPATGLtvngdpq..padlaayA.rRIGHSPLGEPSIDQSLL-.-GRTYDLILPYRVI...RVG...RGQV-LRNQGIQVL.NDIRRKTNVV A0A1T4KS60.1/1274-1414 --K-VDN.....NESFNLNTKKVKPGDKITYQLWLDTNPFDN--.-TSKLTAL..--AMIDDFDEKLLDVDVSKVKV..................YN-KKGEEV.TKLFKS..EIKDGKLIVSANVFVETTNS---................-..----KGQKVQVVDTKKLP.LGQFYKIEFPTVVK...KDI...LKDDEIINTAQQVT.I--------- A0A1T4KS60.1/1633-1771 --KTDNN.....-EKENLNTKEVKSGDQIIYQLWLDTIPFDE--.-TSELISL..--FMEDDYDEKTLDVDVSKVKV..................YN-AKGEDV.TKRFKV..EDKDGKLTVSANVFVETTNSKGE................-..-------KVKIVDTTLLP.FGQVYKIDVPTTVK...EDV...KSGTEIVNTASQH-.---------- A0A261FBQ8.1/827-966 -------.....GDQSDINLKTVFPGQKVEYVLQTKPDFSKAGD.-GYTVKNV..--KFIDTYDT-FLTPDKQTVEM..................QNLSNGQMVaRSHYTTrfDEKQHTFTLTVT-----------................-..-------DQKLVDEWVKQ.GAPQLQVRFEGRVS...KDI...PGKKKVDNQWEFQI.RNSLTPSNIV A0A261FBQ8.1/975-1152 PHKGDEQhpaqgDPSITIDGKTLLKGDKGQYDILLDALSIKD--.PAYKVYRL..--GIVDSYNTKYLKIDEKDLK-..................VTDETGKDV.SDKFNL..KIIDGTVYAFAKLVDTEIPATGEtvkatq...pkdlkayA.mNETYNPLTDPAIDQALL-.-GHTYHVLMPYTVI...KVD...PNTV-VENTALQIT.NDLHGQTNTV W1U747.1/2-135 -------.....---------------KLVYQVWLDTTKFDS--.TNKDNIQT..-VGISDDYDETKLDLDETKIKA..................YDSVTGDEV.TNKFDI..AVNNGVITATLK--------DGF................T..KSLGDAENTQVIDTTKFA.FGRYYKFDIPTTVK...ADV...AAGVDIENTAAQVV.NYYNPVTKKV A0A347WKC5.1/120-263 PVKTNKN.....HAGLIINGKPVVAGSDNLYTLTWDLDQYKGIK.STQEAIRK..GFYYVDDYPEEAVVPKTQRVS-..................ITDNQGQAV.SG-ITV..-----------HNYHSLDEAPQEivdmlkn.adianrlkG.sFQVFSVDNPEQFFNDYVV.KGINLTIVTPMTVK...E--...--------------.---------- A0A242K911.1/290-418 -------.....VGGASVNGKEVFAGQTLIYPVEFKVHTLGV-D.LLEKYSKL..--QVVDKL-SEYVTYEKMWL--..................-----PEDS.SAAANY..DKDSHKVTLTTS-----------................-..---------KNFRESVIKyNAESYTAYVQVKVN...ANA...TSANVIKNTASLVV.NSTTKDSNTV A0A242K911.1/430-569 PVKFVLD.....ETGKNINEQSVMPSSILYYKKNQQVNT-----.LNKDILTKysKFVISDPLPEYVNYISATLLK-..................-NDVEIKGV.KG-IVY..DEKTHTVTFTAD-----------................-..---------AAFLKEMEM.NNETYSLKTKAQVK...ANV...KNGTVIKNVAGTTI.NDTEQKTNEV A0A242K911.1/581-720 PSKRVLN.....ENLEDINEKSVEAGDIIYYDIDQQVNTLNV--.-DIATKYT..QFSISDPFPAQTKYLSSTVLK-..................-NGVEMKDV.KV-ISY..DEKTHTVVFEAD-----------................-..---------SVFLKEMEM.NNETYTLRNKMQVI...EAI...GDKEPIKNTASSSI.NSNKKNTNEV A0A6A0B9Z7.1/658-825 PTKHNYN....tDTGVKIDGYNLLPSDVNEYHITWDLNQYKGSN.VDSLMMTK..GLYYIDDYPEGAVSVKTPK--F..................ID-SNGNAV.SG-ISY..TIYDSIADAPAD-VQQYVKDAGVk.............idG.kFILYSVDNVADFNKNYIQ.TGNTVTIVQPMVTL...KNP..sVEGGSYSNVAYQID.FGNLYKSNTV A0A242K5J8.1/447-585 PIKRVVD.....ENGKDINKKEVLQGEVLIYEIDQPVNELNK--.---DTTSKytEFSFNDPLPSQVSFLSAKIL--..................---KDGKEIkAEKISY..DKNSHTVIFTGD-----------................-..---------AAFLKNMTM.KNETYTLQIKTKVN...QEI...GDKERIENSGSTSI.NKQSQKTNEV B9ECD5.1/320-462 PYKTVTD.....SDEVNKTMNTFETGEVLTFKVNQPTQTLGVD-.ALQRYS--..QFAIVDNLPKNTTYVEGSA-R-..................LLDSTGKAV.SVSPTS.fTYSKDTHTLMFN-----------................-..-------GDAEFLNTMNM.DGKNYTIEFKAKPI...DGL...KEGDVVDNVAKSII.NKAEYPTNH- A0A075LQW1.1/314-451 PTVTVRN.....ASGQDINGRYIGAGQDLIYFVNQEVNTLGQ--.---DVLDKysDWAVAAKLPANLTYSKAELV--..................-N-ASGNVV.KDAGTF..AYNSSTREVTFK-----------................-..------ASDNLLSNVMDY.TGETYSLKIYTKVN...TSV...GNGVKLQNLATSSTiNGVSK----- //