# STOCKHOLM 1.0
#=GF ID   AgI_II_C2
#=GF AC   PF17998.4
#=GF DE   Cell surface antigen I/II C2 terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00480
#=GF GA   27.10 27.10;
#=GF TC   27.20 27.10;
#=GF NC   26.80 26.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0204
#=GF RN   [1]
#=GF RM   24918040
#=GF RT   Structure of the C-terminal domain of AspA (antigen I/II-family)
#=GF RT   protein from Streptococcus pyogenes.
#=GF RA   Hall M, Nylander S, Jenkinson HF, Persson K;
#=GF RL   FEBS Open Bio. 2014;4:283-289.
#=GF DR   INTERPRO; IPR026345;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the second domain (C2) located in the C-terminal region
#=GF CC   found in antigen I/II type adhesin protein AspA from S.
#=GF CC   pyogenes. Together with C3, these two domains form an elongated
#=GF CC   structure, each domain adopts the DEv-IgG fold. Similar to the
#=GF CC   classical IgG folds, it is comprised of two major antiparallel
#=GF CC   beta-sheets, designated ABED and CFG. For the C2-domain, there
#=GF CC   are two additional strands on the CFG sheet. Furthermore, sheets
#=GF CC   ABED and CFG are interconnected by several cross-connecting
#=GF CC   loops and one alpha-helix (DH1). The side chains of D982 and
#=GF CC   N996 in the C2-domain are involved in hydrogen bonding with the
#=GF CC   side chains of R1264 and N1295 in the C3 domain. Main chain
#=GF CC   hydrogen bonding can also be observed between S992 in C2 and
#=GF CC   N1189/G1191 in C3, furthermore stabilizing the interaction
#=GF CC   between the domains. The C2 domain contains one bound metal ion,
#=GF CC   modeled as Ca2+, and both the C2- and C3-domains are stabilized
#=GF CC   by conserved isopeptide bonds, which connect the beta-sheets of
#=GF CC   the central DEv-IgG motifs [1].Other members of this family
#=GF CC   include Major cell-surface adhesin PAc from Streptococcus mutans
#=GF CC   and SspB from Streptococcus gordonii.
#=GF SQ   41
#=GS A0A080N226_9BIFI/741-914    AC A0A080N226.1
#=GS A0A087E963_9BIFI/865-1042   AC A0A087E963.1
#=GS S2W3L5_9ACTN/809-980        AC S2W3L5.1
#=GS F9PUH2_9STRE/1230-1384      AC F9PUH2.1
#=GS F9PUH2_9STRE/908-1057       AC F9PUH2.1
#=GS F9PUH2_9STRE/1557-1711      AC F9PUH2.1
#=GS F9PUH2_9STRE/1884-2038      AC F9PUH2.1
#=GS ASA1_ENTFA/579-736          AC P17953.1
#=GS A0A0F4KNY2_9LACO/338-485    AC A0A0F4KNY2.1
#=GS A0A0F4KNY2_9LACO/1333-1471  AC A0A0F4KNY2.1
#=GS A0A0F4KNY2_9LACO/1177-1320  AC A0A0F4KNY2.1
#=GS A0A0R1RC48_9LACO/598-747    AC A0A0R1RC48.1
#=GS A0A087AW66_9BIFI/690-840    AC A0A087AW66.1
#=GS A0A0R1RC48_9LACO/1074-1218  AC A0A0R1RC48.1
#=GS A0A0R1RC48_9LACO/756-900    AC A0A0R1RC48.1
#=GS ASA1_ENTFA/911-1056         AC P17953.1
#=GS A0A0J5PDU4_9LACO/520-686    AC A0A0J5PDU4.1
#=GS E1MAV2_9STRE/225-390        AC E1MAV2.1
#=GS G5KDW1_9STRE/487-652        AC G5KDW1.1
#=GS A0A0R2GXT2_9LACO/2183-2351  AC A0A0R2GXT2.1
#=GS A0A139NGK2_9STRE/1310-1478  AC A0A139NGK2.1
#=GS A4VUZ2_STRSY/1256-1424      AC A4VUZ2.1
#=GS A3CKQ5_STRSV/1108-1276      AC A3CKQ5.1
#=GS C8NFE4_9LACT/951-1119       AC C8NFE4.1
#=GS SPAP_STRMU/1155-1323        AC P23504.2
#=GS A0A139NGK2_9STRE/1132-1301  AC A0A139NGK2.1
#=GS A4VUZ2_STRSY/902-1070       AC A4VUZ2.1
#=GS A4VUZ2_STRSY/1079-1247      AC A4VUZ2.1
#=GS G5K329_9STRE/517-685        AC G5K329.1
#=GS A0A087CM51_9BIFI/844-1017   AC A0A087CM51.1
#=GS A0A086ZW58_9BIFI/427-599    AC A0A086ZW58.1
#=GS A0A087CIU9_9BIFI/411-583    AC A0A087CIU9.1
#=GS A0A086YVU9_9BIFI/763-936    AC A0A086YVU9.1
#=GS A0A087AW66_9BIFI/849-1024   AC A0A087AW66.1
#=GS A0A087AQH3_9BIFI/838-1013   AC A0A087AQH3.1
#=GS A0A087ABM0_9BIFI/839-1013   AC A0A087ABM0.1
#=GS Q8G499_BIFLO/1016-1192      AC Q8G499.1
#=GS A0A086ZDA5_9BIFI/678-855    AC A0A086ZDA5.1
#=GS A0A087EBE5_9BIFI/734-913    AC A0A087EBE5.1
#=GS A0A086ZH47_9BIFI/724-902    AC A0A086ZH47.1
#=GS I3WIU3_BIFBI/1254-1431      AC I3WIU3.1
A0A080N226_9BIFI/741-914               PSKHDVSSK...DPTISIDGKTLLQGDTGVYRISIDASQANT.......AYQVWRL......GVVDDYDEEHLNVDPTAIEV..................IG.SDGLDY.TKAFNI..QVRDGVLYAFAKTVDTIVPATGRILKGDPQPSDLKAYA..QADGHDPLTQPAIDQSLL..GRTYELTVPYTVA.KA....DGSV.VRNTATQISN....DVHKDTNTV
A0A087E963_9BIFI/865-1042              PVKTDTQGSRQGDPTISIDGRTLMLGDTGTYTVTLDAKQQNQ.......AYDVWKL......GIVDDFDEQYVSIDQSKIAV..................LG.ADGKDY.TSRFNI..KVIDGVVYAFARTVDTKVPATGATVKGDPQPADLAAYA..KSDKHDALKSPAIDQSLL..GQSYQLVMPYTVI.KVS...KGYV.VKNTATQVVN....DMRKQTNQV
S2W3L5_9ACTN/809-980                   PHKEDLN.....TNNVDINGKTVIQGDVLRYRLTLDGGMPREK.....LAYDVHKF......GMIDDFDEEYLDVAPENIK...................VTTLDGADV.TDKFNT..QVRDGKFYVFAKHVDHTNNA.GELIKG.VQPENLAEYV...NKAIDPINDPIIDQALL..GKKYYVIADATVK.KEK...DGYV.IKNTAWQNTE....NSLIQTEIV
F9PUH2_9STRE/1230-1384                 ADDAANN......EAENLNTKTVERGSKLVYQVWLDTTKFDAAN.....KDNIQTV......GISDNYDKAKLNLNAADIKA..................YDSVTGAEV.TDKFDI..AVNNGVITANLK.........................AGFTKSLGDAENTQVIDTTKFEFGRYYKFDIPTTVK.DDV...VAGADIENTAAQVVN....YYNPTTKKV
F9PUH2_9STRE/908-1057                  VDKTTNN......EPENLNTKTVKRGSKLVYQVWLDTTKFTE.......ANNIQYV......GVSDTYDADKLDVNAADIKA..................YDSVTGAEV.TNKFDI..KVENGKITATSK.........................DEFIK...DKVNAPVIDTTKFEFERYYKFDIPATVK.ENV...AAGDDIENTANQIVH....VYNPVSKTV
F9PUH2_9STRE/1557-1711                 VDKTDNN......EAENLNTKTVKRGDKLVYQVWLDTTEFDANN.....KDNIQSV......SISDDFDETKVDVDASAIKA..................YDSVTGDDV.TDKFDI..KIENGVMTATLK.........................AGFTKSLGDAENTQIIDTTKFEFGRYYKFDIPATVK.TDV...EGGVDIENTAAQVVN....YYNPTTKKV
F9PUH2_9STRE/1884-2038                 ADKTDNN......EAENLNTKTVKRGAKLVYQVWLDTTKFDANN.....KDNIQSV......SISDDFDETKVDVDASAIKA..................YDSVTGEDV.TAKFDI..SIVDGVINATSK.........................AELTKSLGDAENTQVIDTAKLAFGRYYKFDIPARIK.ETA...KEGVDIENTASQIVH....QYDPTKKTV
ASA1_ENTFA/579-736                     PNKEVTD......GQKNINDLNVKRGDSLQYIVTGDTTELAKVD.....PKTVTKQ......GIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDV.TASYDL..HLDQNTVTAMMK.....................................TNADDSVVLAMGYKYLLVLPFVVK.......NVEGDFENTAVQLTN....DGETVTNTV
A0A0F4KNY2_9LACO/338-485               PAKPIKDVI...ENGQSINGKLVIPHEKFEYTVSQKVGI.........MGQDMLTK..YRQFEISDPLPKEVTYLDSAYV....................VDDSTGKRLDANAGAFTYKNGILTFKFSYN.......................................YLKNIMAYEGETYTVHIPVQVK.GNVKLSSKLKSIDNDASTVIN....GRQRNTNKV
A0A0F4KNY2_9LACO/1333-1471             PTKKVVN.....KDGKDINNTTVKVGDTLYYHVDQKVGT.........LGKDLSER..YPQFTIKDQLDQRLTYVNAYV.....................VNKADGKKM.SNDSEISFDESSNTVLFTAS......................................PDFLKAMPLKGETYELVIEVKVN.......KGAATIANAETRSDK....SGNTAETSQ
A0A0F4KNY2_9LACO/1177-1320             PTKSVVN.....HDGKDINHQIVSDGDTIYYHVDKKVGT.........LNQDLAQR..YKEFSMTDKLDHNLTFIKAYV.....................INKETGKTV.SQPAEI..TVSDNTVTWKAS......................................ANFLKSMPLKGETYELVIEAKVNVSDKASSTDEVTIENIASVSID....NQPQQTNAV
A0A0R1RC48_9LACO/598-747               PVKTVTD.....TSGRSIDGQKVLPGSVINYKVEQDINHFGTDLLYPYTNFEIDDTLPNQVNGLTSDY.........KLVAI..................NNDGSQSDVDTGWYKI.ITSAQGVVSASLMSNILADGTSGF.................................YAPTAKGYELVMPVSVK.MDA...SGT..LVNTASTNVG....KTHQDTNTT
A0A087AW66_9BIFI/690-840               VKKDVIGEASQGGAQESVDGKVVFPGQKVEYQLTTTPKLPGQ......LAYDVKNV......VVTDQYDQ.YLVPDKQTVEV..................TDLGNGKIIPKAQYTTKWDDTKHLFQLAFD....................................DAYVKANWGKGQNPRLLIRFEGTVS.KDA...PTDTRVDNQWMLTLN....NSITPSNQV
A0A0R1RC48_9LACO/1074-1218             PTKTVDD.....DSGNDIDNKAVARGDHLDYNGTWDLTGFTN......WAFNTSNF..DAGFGEYDLL.EGPAKMDPDSLK...................FADANSHDI.TDQLEITWGVDHKSFTVKPK...................................GDIKSFVQKYA..GTKLSFTYTATPI.TGE.....SGTIKNTIYQNSF....GQTSKTTTM
A0A0R1RC48_9LACO/756-900               PTKTVTD.....QNGNDINGKNSVRGDTKDYEILWDLRDVDGTA....LTQDQINK....GVSIWDFYPARYESIQKGTLV...................IKDANGKDI.SSEVSIDWDDADGKFTVSAK....................................DPVQFITEHK..GTEPKVDFKTTVK.ADV.....EGESDNTAHQNTF....GNDTPTNTI
ASA1_ENTFA/911-1056                    PTKAVHN.....KKGEDINHGKVARGDVLSYEMTWDLKGYDKD.....FAFDTVDL..ATGVSFFDDYDETKVTPIKDLLR...................VKDSKGEDI.TNQFTISWDDAKGTVTISAK....................................DPQAFILAHG..GQELRVTLPTKVK.ANV.....SGDVYNLAEQNTF....GQRIKTNTV
A0A0J5PDU4_9LACO/520-686               PHKSETN.....EEDENNNTKPVMRGDIVKYYVNQDYTGYKDAD....LTGSTIAT....TPGAYDNYDDKTT....ANPGTEKTYLMPEGYKFNPDTVAQDLKKGQLLDNNEFVYQYDNQGHKFTVTAK....................................DAQDFLTKYIQEGRTLVTTFDTTVN.DDV.....DGQIQNTAYQLDFQSKTGRSFQTETV
E1MAV2_9STRE/225-390                   PVKAITD.....NFGNNIDSANTFDKNVK.FSLTTDYKPYSTFT....ADSETHGK....TWAMVDDVQDGAYMVDDNKIT...................MKDSTGKDV.KDLFNM.............YHVLSEKERTHE.IQNILKEAGLNPKG..EFYMFVAKDSASFYKNYVRQAKNITIDLPAHLL.VE.....KGQIVKNDFHQIDF....GNGFVSNLV
G5KDW1_9STRE/487-652                   PSKAVID.....EAGQSVNGKTVLPNATLDYVAKQNFSQYKGIK....ASAEAIAK....GFAFVDQPNEA...LGELTVKS..................IKASNGDDV.SSLLEM.............RHVLSKDTLDQK.LQSLIKEAGISPVG..EFYMWIAKDPQAFYKAYVQKGLDITYNLSFKVK.KEF....TKGQIQNGVAQIDF....GNGYTGNIV
A0A0R2GXT2_9LACO/2183-2351             PTKSETD.....ENGKTVDRQQLKAGQHLMINLGWDLSKYKGIV....TTDDMIKK....GFFFLDPLDAKALAAGDLTKAT..................VKTADGKPV.EG.IEF.............TKYDSLADAPEY.IQEQVKANHLANLFQTPFVVASATDPEAFFNTYVKAGAKLNVAIPVTIK.DGF.....TGSFSNTAYQFEF....GRATPTNTV
A0A139NGK2_9STRE/1310-1478             PKKINTN.....LQGVNIDGKMVLPNTINYYKVTANYSSYKGIE....ADEEIIQK....GFFIVDDYPEEALTINEAGIQ...................IHDAAGNVV.KG.LTA.............TIYESLDKAPEM.VQQAMKARNFTPKG..AIQIFTADNPVDFYNTYVKTGQVLTITNPMTVK.EEMA..KEGGQYENTAYQVDF....GIAYVTETV
A4VUZ2_STRSY/1256-1424                 PHKSNTN.....QEGISIDGKTVLPNTVNYYKIVLDYSQYKDMV....VTDDVLAK....GFYMVDDYPEEALTLNPDGIQ...................VLDKDGNRV.SG.ISV.............STYASLSEAPKV.VQDAMAKRQFTPKG..AIQVLSSDDPKTFYETYVKTGQTLVVTLPMTVK.NELT..KTGGQYENTAYQIDF....GLAYVTETV
A3CKQ5_STRSV/1108-1276                 PTKVNKN.....KAGLVIDGKEVLAGSTNYYELTWDLDQYKGDK....SSKSTIQK....GFYYVDDYPEEALELRPELVK...................LVDADGKAV.AG.VTV.............THYESLETAPAA.VRELLQKANITVKG..SFQFFAADDAQAFYDQYVVTGKSLTITSPMAVK.EGMG..RTGGKFENKAYQIDF....GNGYATDVV
C8NFE4_9LACT/951-1119                  PHKINKN.....ENGVVIDNKNVLAGSMNYYNLTWDLDQYKGDK....SSAETIAK....GFFYVDDYPEEALDANLDLVK...................IKDANDREV.TG.ITV.............KNVKDISELDPH.IQDLLKKAGIKPKG..AFQLFLADNPQSFYDTYVSKGIDLTIISPMRVK.DEMG..KIGGKYENKVYQIDF....GNGYESNVV
SPAP_STRMU/1155-1323                   PTKVNKN.....ENGVVIDGKTVLAGSTNYYELTWDLDQYKNDR....SSADTIQK....GFYYVDDYPEEALELRQDLVK...................ITDANGNEV.TG.VSV.............DNYTNLEAAPQE.IRDVLSKAGIRPKG..AFQIFRADNPREFYDTYVKTGIDLKIVSPMVVK.KQMG..QTGGSYENQAYQIDF....GNGYASNII
A0A139NGK2_9STRE/1132-1301             PIKHNRN.....SSGVIIDGKTVAVGSTNYYHVTLDYDQYKGIK....AGKDAILK....GFGAVEDYPEEAVTIKTDALK...................MVDSDGKEV.TG.LSV.............YHYESLDKVDNDKVKAFLGNSNIKPKG..AFQVFLADNPESYYKTYIETGKTITIIDPMVVN.ESLY..NSGQKFENIAYQVDF....GNGYRTETV
A4VUZ2_STRSY/902-1070                  PDKNNEN.....ADGVLINDTVVTLGTTNHYRLIWDLDQYKGDR....SAKETIAR....GFFFVDDYPEEVLDVVENGTA...................VTTLEDQKV.SG.ITV.............KTYASLNEAPKD.LQDKLARAKITPTG..AFQVFLPDDNQVFYDQYVQTGTSLALLTKMTVK.DSLY..GPTKTYTNKAYQVDF....GNGYETKEV
A4VUZ2_STRSY/1079-1247                 PKKQNLN.....KDKVDINGKPMLVGTQNHYTLSWDLDQYRGIK....ADNSQIAQ....GFYFVDDYPEEALLPDETAIQ...................FITSDGKTV.SG.ITV.............KAYSQLSEAPKT.LQAALSKQKIQPQG..AFQVFMPEDPQAFFESYVTKGENITIVTPMTVL.ETML..NSGKSYENVAYQVDF....GQAYETNTV
G5K329_9STRE/517-685                   PQKQNEN.....ADGVLINDKVVALGTTNHYRLTWDLDQYKGIE....VDKDQIAK....GFFYVDNYPEEAMLPDSESVQ...................IFTPDGQVV.SG.IRV.............TTYASLSEAPNA.LQEALAKRKITPKG..AIQVFEPEDAKTFYETYVTKGQNLTIVTPMTVR.EDLY..NSGKTYENIAYQVDF....GQAYATNTV
A0A087CM51_9BIFI/844-1017              PSKQDTQK....DAKINIDGMAAVLGDRIFYRVNLDASKLDN......TAYVVQRL......GMVDDYDEQYLKLDTTGIQV..................LD.AQGSDV.TGKFNI..QEKDGIVYAFFKTVDTTIPATGETVLGDPQSSDLKAYS...TEKLDPLTSPAIDQKVL..GQTYKIVLPMTVK.AVK...DGYT.VKNTAIQVTD....NEQKLTNTV
A0A086ZW58_9BIFI/427-599               PVKQDTQA....DASVDIDGRTVLVGDRLYYRITIDAAGLAD......PAYPVRRL......GVIDDYDETVLDVDEAGIQM..................LG.EQGADV.TDLVNV..QVADGVVYAFFKTVDTTLA.DGTVLPGDPQPADLAEYA...RRELSAERDAGIDQSLL..GKTYQLVLPMTAI.AAA...DGGS.VENTAVQVTN....KRRAVSNTV
A0A087CIU9_9BIFI/411-583               PVKQDTQA....DSSVDIDGKTALLGDRLYYRITIDATGLAG......QAYPVRRL......GVVDDYDERRLTLDMPGVHV..................LD.ATGKDV.TDRLNI..QDRDGVVYAFFKTVDTTLP.DGTVINGDPQPADLAAYA...DRELMPYADPGIDQSLL..GSDYQLVLPMTVT.DTG...EGTK.VENTATQVTN....HRRAVSNTV
A0A086YVU9_9BIFI/763-936               PDKQVTQK....DPSVIIDGRTALLGDKLYYRVGIDARGLDQ......AAYRVQRL......GVIDDYDQEHLKVDEAGIQV..................LD.DSGADV.TAKLNI..QVKDGIVYAFFRTVDTLVPATGETIKGDPQPGDLKAYA...GRKLDPVKDPGIDQRVL..GHSYQLVLPVTVI.SVK...DGYT.VSNTAKQVSN....DRQDVTNTV
A0A087AW66_9BIFI/849-1024              PVKEDTQK....DPSISIDGKTALLGDVLYYRVHLDLKNLDRKG....TAYNVMRA......GIVDDYDDEYLTADERNVEV..................LN.AKGEDV.TAKFNV..QFRDGVAYVFAKTADTKVPATGETVKGDPQPKDLKAYS...QAKLDPLKDPAIDQSLL..GQEYTVVLPMTVT.KVT...DGYV.VKNTATQIVN....DVKKSTNTV
A0A087AQH3_9BIFI/838-1013              PDKQDTQA....DPTISIDGKTALLGDRVYYRIGLDLEHIDQND....LAYRVQRA......GIVDDYDQEYLAADETGVEV..................LD.AAGKDV.TSKFNI..EFRDGVAYVFARTVDTEIPATGETLKGDPQPEDLKEYA...DRKLDPLKDAYIDQSLL..GQKYQVVLPMTVT.KVT...DGYV.VKNQATQITN....DRKDTTNVV
A0A087ABM0_9BIFI/839-1013              PVKKDTQA....DPSISIDGKTALLGDRIYYRVIIDAKQTNQ.......AYKVWRL......GMTDDWDDEYLSLDAKRIEV..................TDTATGKDV.TAKFNI..AAIDGVAYVYAKTADTKVPATGETIKGDPQPKNLKEYA..EKKDHDPLKEPAIDQSML..GTSYEVILPMTVI.KVT...DGHI.VKNKATQVVN....DTRKDTNEV
Q8G499_BIFLO/1016-1192                 PSKQDTQK....DPTISIDGKTALLGDKVYYRVNIDASRLTD......TAYKVWRL......GMTDDYDQEYLTLDAKHVEI..................LD.ETGRDR.TGEFNI..QDKDGVLYAFAKTVDTQIPATGETVPGDPQPDDLKAYSEKTDKDYDPLKDPSIDQSLL..GHTYQVVMPMTVT.KVK...DGHT.VENTATQVTN....DKRDKTNTV
A0A086ZDA5_9BIFI/678-855               PTGTQTTTG...EDSTSVDGKSVLLGDKFVYRATLKSAQASS......AASPVWRL......GLVFDYDANHVTADTSNIRL..................IDMTTGQDA.TVRANITTDAKRGLVYAFLKTVDTTV..NGHTVKGDPQPTDLAAYA..ASDDHDPTRDPAIDQTVL..GHEFQLVIPVQVT.KTS...DALVRLDAKATQITD....RTRVDGEVM
A0A087EBE5_9BIFI/734-913               PGKEDNQSEAQGDPTVSIDGRTLLMGDTGNYVVSLDLTQRDQ.......AYKVWRA......GIVDDFDDGYLKIDPQDVEV..................LD.AAGQDV.TDRFNV..AIRDGVAYVFAKTVDTGIPATGETVKGDPQPSDLKAYSELTDEDYDPLKDPSIDQSLL..GQTYRVVLPYTVV.KAA...DGYV.VENTATQIVN....DLSKQTNTV
A0A086ZH47_9BIFI/724-902               PVKRNNKTNES.GAAVSIDGRTLMVGDTGEYELELDAAQSDL.......AYRVWRL......GIIDDVDDEYLRIDASKIKI..................TG.DDNRDY.SDRFNV..AQERGVFYMFAKTVNTFISATGETVSGDPQPANLDRYAHLTQSDHDPLRDPAIDQTLL..GHVYRITLPYRVI.KAS...AGHV.VHNVATQVVN....GQSRVSNEV
I3WIU3_BIFBI/1254-1431                 PSKKDTQSSAQGDPTVTIDGKTMLLGDTGNYTVTLDLKQKDN.......AYRVWRA......GITDDYDEQYVSILPSDIEV..................LD.QSGEDV.TGRFNV..QVRDGVAYVYAKTVDTFVPKTGRTIPGDPQPEDLAAYA..SASGHDPLNEPAIDQTLL..GQEYQVVMPYKVV.KVT...DGYA.VRNKAVQVTN....DTKAETNEV
#=GC seq_cons                          PsKpsss.....csuhsIDGKsVhhGsphhYplshDhsphcs.......uhclhph......uhsDDYD-chlslctsslp...................lspusGc-V.Tsthsl..t.tpshhhh.h+phtsh..hst..l.t..t.ttlt.hu....p.h.s.ss.sh.pshl..GpshplshPhTVp.csh...pstsplcNsAhQlst....spphsTNsV
//