# STOCKHOLM 1.0
#=GF ID   DDAH_eukar
#=GF AC   PF19420.2
#=GF DE   N,N dimethylarginine dimethylhydrolase, eukaryotic
#=GF AU   Mian N;0000-0003-4284-4749
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Pfam-B_5784 (release 5.2) and Pfam-B_1850 (release 5.5)
#=GF GA   23.00 23.00;
#=GF TC   23.00 23.00;
#=GF NC   22.90 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0197
#=GF RN   [1]
#=GF RM   11504612
#=GF RT   A novel superfamily of enzymes that catalyze the modification of
#=GF RT   guanidino groups. 
#=GF RA   Shirai H, Blundell TL, Mizuguchi K; 
#=GF RL   Trends Biochem Sci 2001;26:465-468.
#=GF RN   [2]
#=GF RM   14675764
#=GF RT   Prediction of the structure and function of AstA and AstB, the
#=GF RT   first two enzymes of the arginine succinyltransferase pathway of
#=GF RT   arginine catabolism. 
#=GF RA   Shirai H, Mizuguchi K; 
#=GF RL   FEBS Lett 2003;555:505-510.
#=GF DR   SCOP; 1jdw; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family contains N(G),N(G)-dimethylarginine
#=GF CC   dimethylaminohydrolases (DDAH) from eukaryotes. It also includes
#=GF CC   arginine deiminases and DDAH from prokaryotes. These enzymes are
#=GF CC   involved in arginine metabolism and belong to the
#=GF CC   amidinotransferase (AT) superfamily as they share the alpha/beta
#=GF CC   propeller fold, which includes structurally important residues
#=GF CC   (buried hydrophobic residues, buried hydrophilic residues
#=GF CC   hydrogen-bonded with mainchain groups and the hallmark of three
#=GF CC   consecutive buried Gly residues near the C-terminus, conserved
#=GF CC   among its members [1,2].
#=GF SQ   12
#=GS Q9KKV6_VIBCH/33-321  AC Q9KKV6.1
#=GS Q97M24_CLOAB/34-291  AC Q97M24.1
#=GS Q9KBZ5_BACHD/31-282  AC Q9KBZ5.1
#=GS Q5NES8_FRATT/17-303  AC Q5NES8.1
#=GS Q5NHY2_FRATT/17-305  AC Q5NHY2.1
#=GS A3HWB9_9BACT/7-297   AC A3HWB9.2
#=GS G2IWP8_PSEUL/15-300  AC G2IWP8.1
#=GS A6L2I9_BACV8/17-307  AC A6L2I9.1
#=GS C1DBM8_LARHH/17-309  AC C1DBM8.1
#=GS Q8RGP8_FUSNN/21-309  AC Q8RGP8.1
#=GS A4RXL6_OSTLU/7-300   AC A4RXL6.1
#=GS A1SI98_NOCSJ/33-323  AC A1SI98.1
Q9KKV6_VIBCH/33-321             FGFN.AQTAQDNAFQNP..LALSAETILQRAMSEFNAMVNGLRQAGVDVVIFDYPLGQ.GETPDAVFPNNWFST...TEAGELFLFPMACANRRLEVRPEALIDTLQKQ..GFAVKKQHSLL.AFTEQQAFLESTGVMVMDHPNRTIYAGLSQRCDREVLEVYAEQIGYSRVVSFQT...RLPSGSPIYHTNVMMAIGEHFCVICDEAIPEYE.RRFVVKSLAKDK..QVISISIEQMNHFCGNILQLET.ADGQ..KVIA..MSQSAYEAFTLTQLNQLAT..HGKLLPFAVPTIETIGGGSVRCMLAELF
#=GR Q9KKV6_VIBCH/33-321  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
Q97M24_CLOAB/34-291             IEIEPIDEISKSWYE......KEYEINKEECIKEHEELVQAYQQNGIEVILIDG.K...PKLKNQVFSRDFGAT....IKEGYILGNFKETVRKEETKEYEDKLKE............LEIPCVAKCEKGVFEG.GDFWFLDDKTIAIGTVD.RTNLEGIEEIRRQIERF.....GYEVIAARAEKGNLHLDMCFNVVAERLAVACVEVLSQD....FLRVLKEKK.FQLIDVPKEGIAKHYCNIEAL.....GNNKV........MSFYNNKKVNEKLEAY..GIEVIKISLNELL.KSGGGIHCMTFPII
#=GR Q97M24_CLOAB/34-291  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
Q9KBZ5_BACHD/31-282             MTLRNMINETQKKFK.......NEDIHIEIAMEQHHEFVRVLQKHGVNVHLLPV.N...EKYPEQVFTRDIGFT....LGQTTFVADMAHDVRKGEENTLKEWLEL............KGIS.YYNLVSDEIEG.GDVI.IDRHSIYIGISN.RTNMAAIEHIQRLLPEY.......EVIPVPFHPKYLHLDCVFNIVSPHEALIYPGVMNRKEEKLIASR......YDLIEVTEEEQFTLGTNVLSI.....GHKRV........ISLPVNTNVNEQLRKR..GFDVIEVDITEII.KSGGSFRCCTMPLR
#=GR Q9KBZ5_BACHD/31-282  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
Q5NES8_FRATT/17-303             FCFN.QETSVNNAFQNQ..LDISNDELQNRVIHEFENMVAKIRANGIEVIVLES.K...PNTPDAVFPNNWFSTHLIDNQPYVFIYPMYTQNRRNEVQVDKLLEQLNKL..TTTNYKVIDLR.G..DYSKALEGTGVFIFDHEFKTAYMSLSPRADAQLAQQVCDKIGYK.LVTFTS....YDKKGPIYHTNVMLSIGEYLAIVCLESIKSAIERELVIKTLQQSN.KQIIDISLEQMYQMCGNVLEV.....KNKADKSFLILSQTAYNGFSQSQLALISK..YATPIACDITNIEVVGGGSARCMLAEVF
#=GR Q5NES8_FRATT/17-303  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
Q5NHY2_FRATT/17-305             FALNTQKTDSDDAFRRA..VRLNEKAIQALARDEFYEMVNYIRSKDIKVIIMKS.P...KNAADAVFTNDWLSTHIINGQGYIFIYPMYSESRRCEIQPQQLLQTLESE..LKIKYKLKDFR...GDHSEALEGNAALVFDNSTKKVFLSKSPRADEKLAKKVADELGYE.LITFTS...YDHKDRPIYQTTQMLSIGEKLIFVCLESIKCDKDRDIVAQALHQSN.KTIVDVSQKQVHLRCCNSLEVK...NKQGKSYLI..LSTTADMGFTDQQKQLIDL..HCTRLLCHVKTIEDVGGGTARCMVAEIL
A3HWB9_9BACT/7-297              FGFN.TETAANNFYQQM..DDRSGKEIQELARKEFDGFVALLRDQRVNVEVVED.TEN.PVKTDAVFPNNWFST...HSDGKLIMYPMFSPNRRLERRKDLIEMLMHK...GYQVSDILDLS.FFENDGQYLEGTGSMVMDHESKTIFACYSERTHPFPLQYVAELLDYK.VVGFHSVQEIEGVQSPIYHTNVMMHIGRDLAVVCLDSIPKASEKQLVQRTLTNNG.KKVIPITPKQKFNFAGNMLELS...NDGGEKFTI..MSQTAYDSLNPGQIQLIEK..YTTIISPQIPTIEKLGGGSARCMIAEIF
#=GR A3HWB9_9BACT/7-297   pAS   .............................................................................................................................................................................................*...................................................................................................................*......
G2IWP8_PSEUL/15-300             FLSN.PQTSPSNTFQKS...DIDHQEAQQNALAEFDAYAGELRRCGVDVLVIDD.TVE.PHTPDSIFPNNWISL...HADGKVLLYPMEAPNRRLERNNKVLEKITEA....FAVEEVIDLS.GFERVGQYHEGTGTMIFDHNQKMAYVCFSSRSSEAVMKAVSETIGYQ.ALWFHS...VDRHGKPIYHTNVMMCVGKTLAVVCLESIRDRNERTALVQALTASG.KEIIDISYDQLEHFAGNMLELS...SRDGEAVFA..LSRQAWSSLTPEQQTAISS..YARVAQAPIDTIERLGGGGARCMIAEIF
#=GR G2IWP8_PSEUL/15-300  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
A6L2I9_BACV8/17-307             FGFN.EETAANNYFQQR..TVAAGETVQACALKEFRGMVDKLRANGIEVIAVQD.TPI.PHTPDSIFPNNWVSF...HDDGTVVLYPMFAENRRAERRADILQRIESE...GFSIRRKVDYT.GFEEENRFLEGTGGIILDRVNRYAYAALSQRVDEALFGRFCKEQNFI.PVSFHAYQTVNGQRLPIYHTNVMMCVATDYAVVCLDSIDDVEEREQVCHVLRQTG.KEIIAISEEQMHHFAGNMLQV.....ENGKGALFLVMSQSAYDSLDEGQLQRLSK..YNALLPMPIPTIETLGGGSARCMMAEIF
#=GR A6L2I9_BACV8/17-307  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
C1DBM8_LARHH/17-309             FYFD.TETAANDFFQKN..LGEKRDVVQAKALIEFDAMVDLLRSKGITVHVLQD.SNQVMDTPDSIFPNNWFVS...MEGGHLMLCPMWAPNRRHERLKFLGQLVDLI...GHDKLKVSNYGPAHEAQSKFLEGTGAMILDRVNMKAYACLSPRCDEDVFKKFCKEFGFK.PVAFHGFQTYEGKRAAIYHTNVMMALGEAFAVVCLSAIDDLTERAALVKELQGDG.KEIIDVTEDQINNFAGNEIELCNADGK....RFT.IMTKATYDCLTPEQRAVIEK..TSEIISPDVKTIETYGGGSVRCMISEIF
#=GR C1DBM8_LARHH/17-309  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
Q8RGP8_FUSNN/21-309             FTFN.EETAVNNHYQKK..DNKPIQEIQNNALTEFDNMVEKLKKTGIDVKVMQD.TKK.PHTPDSIFPNNWFST...HYSNTVVLYPMFAENRRLERTDNLYDYFDET.....DNLNVVDYS.SLENENIFLEGTGSLVLDRKNKKAYCSLSERANEKLLDIFCKDAGYK.KIAFHSYQTVDEKRKPIYHTNVMMAMGENYAILCADSIDNLKERENVIRELKNDD.KEIVYISEYQVEHFLGNTIEL....INNENVNIC.VMSATAYSVLTDEQKNIIEK..YDVIVPVDVHTIERYGGGSARCMIAELF
#=GR Q8RGP8_FUSNN/21-309  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
A4RXL6_OSTLU/7-300              FGTN.AQAARDNHFMASTSDGLSVLEIRERAVAEHKALYRGLRALGIEINLFTH.DEK.HATPDACFPNNWHTL....RDGKLKLFPMKDENRRLERREDIIEFLKHKHPNLVVDDSLLRYE..RQDPPKFLEGTGSLVVDHEERVAYVALSERAHEEVVAEHCAAENLT.PITFKA...LDARGRPIYHTNVMMSVCSSVAIVCADSIADPADRRRVLDALAAGGRREIITITHAQVDAFCGNVLELRTASGE....PAL.ACSARAFAAFDDAQRARLRAAFDDRVVAVDFSTIERVGGGGVRCAVAEHF
#=GR A4RXL6_OSTLU/7-300   pAS   .............................................................................................................................................................................................*...................................................................................................................*......
A1SI98_NOCSJ/33-323             FVPN.PATAADNAFQRDIPAGQSEDATSSKALAEMDALAQALRDVGVRVHVFRD.ED..HTRPDSVFPNNWLST...HAGGYVAVYPMYASNRRHERRADVLEMLKSD....YRTQTIVDYS.GLEPDGIFLEGTGAMVLDHVSRVAYMAVSHRADTHVLERFCSDFNYE.PMAFEA...VDSEGVPVYHTNVLACVGTDIAMIALGMIPDEQRREQVRERLTVNG.RTVIELTEQQIRDFAGNAVELCGRTETGKRRYVM.AMSGRARRSLRPDQIAAIEE..SCEIVSVDIPTIE.LAGGSVRCMIAGVH
#=GR A1SI98_NOCSJ/33-323  pAS   .............................................................................................................................................................................................*...................................................................................................................*......
#=GC seq_cons                   FshN.tpTussNtFQpt...shstctlpppAlpEFcshVptLRppGlcVhlhps.s....psPDulFPNNWhST...ptsGplhlaPMhspNRRhEcpsphlphhhpp....ht..pll-hs.shpspspaLEGTGshlhD+pp+hAYsslS.Rscpplhcphscphsap..lsFpu...hsspptPIYHTNVMhslGpshAlVCh-uI.shp-RchVhcsLptss.+plIslopcQhppFsGNhLEL.....pptphhhh..hStpAasuhsssQhphlpp..hspllssslsTIEplGGGSsRCMlAElF
//