# STOCKHOLM 1.0
#=GF ID   UNC80_C
#=GF AC   PF20262.1
#=GF DE   Protein UNC80 C-terminal region
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Sonnhammer ELL
#=GF GA   22.10 22.10;
#=GF TC   22.10 22.40;
#=GF NC   19.90 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   24904279
#=GF RT   The sodium leak channel, NALCN, in health and disease.
#=GF RA   Cochet-Bissuel M, Lory P, Monteil A;
#=GF RL   Front Cell Neurosci. 2014;8:132.
#=GF RN   [2]
#=GF RM   21040849
#=GF RT   Extracellular calcium controls background current and neuronal
#=GF RT   excitability via an UNC79-UNC80-NALCN cation channel complex.
#=GF RA   Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D;
#=GF RL   Neuron. 2010;68:488-499.
#=GF RN   [3]
#=GF RM   31690562
#=GF RT   The NALCN Channel Regulator UNC-80 Functions in a Subset of
#=GF RT   Interneurons To Regulate Caenorhabditis elegans Reversal
#=GF RT   Behavior.
#=GF RA   Zhou C, Luo J, He X, Zhou Q, He Y, Wang X, Ma L;
#=GF RL   G3 (Bethesda). 2020;10:199-210.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family represents the protein UNC80 found in eukaryotes, a
#=GF CC   component of the NALCN sodium channel complex. NALC is a cation
#=GF CC   voltage-independent channel activated by substance P,
#=GF CC   neurotensin, acetylcholine and noradrenaline that controls
#=GF CC   neuronal excitability. UNC80 forms a complex with UNC79 and both
#=GF CC   are key regulators of the channel and required for the proper
#=GF CC   expression and axonal localisation of NALCN. UNC80 is required
#=GF CC   for NALCN control by GPCRs and essential for its sensitivity to
#=GF CC   extracellular calcium. This protein acts as a scaffold for Src
#=GF CC   family of tyrosine kinases (SFK) and UNC-79 to mediate
#=GF CC   interaction with NALCN [1-3].
#=GF SQ   16
#=GS A0A5N5PXL2_PANHP/1880-2964  AC A0A5N5PXL2.1
#=GS A0A4W3J4U0_CALMI/1857-2944  AC A0A4W3J4U0.1
#=GS A0A1D2NM70_ORCCI/1993-3075  AC A0A1D2NM70.1
#=GS A0A2R2MLL0_LINUN/1431-2537  AC A0A2R2MLL0.1
#=GS R7T6S3_CAPTE/1812-2911      AC R7T6S3.1
#=GS A0A2T7NMQ5_POMCA/1838-2924  AC A0A2T7NMQ5.1
#=GS A0A210PLR2_MIZYE/1971-3067  AC A0A210PLR2.1
#=GS K1R226_CRAGI/1972-3055      AC K1R226.1
#=GS A0A3M0L5T6_HIRRU/1755-2815  AC A0A3M0L5T6.1
#=GS A0A2K6H0C3_PROCO/1864-2867  AC A0A2K6H0C3.1
#=GS A0A384BT73_URSMA/1944-3031  AC A0A384BT73.1
#=GS A0A2I2YAW1_GORGO/1815-2902  AC A0A2I2YAW1.1
#=GS W5MBC6_LEPOC/1872-2867      AC W5MBC6.1
#=GS A0A4U5TVT9_COLLU/1744-2818  AC A0A4U5TVT9.1
#=GS A0A2I4BUX5_9TELE/1914-2988  AC A0A2I4BUX5.1
#=GS A0A6A5DTX8_PERFL/1696-2770  AC A0A6A5DTX8.1
A0A5N5PXL2_PANHP/1880-2964             DDENTTEHTPTHHMLQPPQAVFPACICAAVLPIVHLMEDGDIREDGVAVSAVAQQVLWNCLIEDPALVLRHFLEKLTVSNRQDELMYMLRKLLLNIGDLPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPEARSANYFLMDKRWNLIHYAKTYVRDIYPFRRSVSPQLNLVYMEP.........................EKGQELIQKQVFSRKLEEVGRVLFLISLTQRMPA....MHKQSHVSLLQEDLLRLPSFPRTAIDAEFTLFNEPL.GKELFGMDTLHKVLWIKLLEEMFLGMPSEYPWGDEIMLFLNVFNGALLLHPEDSALLRQYTATAINTAVHFNHLFSLSGYQWILPTMLQTYADYESNPLLRRGIEFCCRQFYILHRKPFILQ..........LFASVAPLLEFTTCTSTGL..SKGVSAQCLFDLLVSLEG.ETADSLDALELVKAEKPLRSLDFCYGNEDLAFSISESIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKSNSQALESASVARDEIAAIAALATSLQALLYSVEALTRPMTAPQMSR..CDQGHKGG.TAANHTMSGG...PNT...................RDNLHL....LEEG...QGMPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNVAGEPRVTAL.ELLDIKSHMRLAEIAHSLLKLAPYDTLTMESRGLRRYITEMLPITDWSSEAVRPALILILKRLDRMFNKIHKMPTLRCARPQALYSRRQVEWEAASSLIEGICLTLHRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVAMQIQALKDDFPLSQVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPQIEQAEVFLLLQTVINILLP..PRIISTSRSKNFV......LDASPAH.CSTPGDTGKDLRREG.....LAESTSQAAYLALKVVLVCFERQLGNQWYRLSLQVKEMALRKVGGLAFWDFIDFIVRTRIPIFVLLRPFIQCKLLTQPAESQEEITARHHIADQLERRFIPRSLCKSSLFAEFNNELKILKEAV
A0A4W3J4U0_CALMI/1857-2944             DEENATEHTPTHHVLQPPQAVFPACICAAVLPIVHLLEDGEVREDGVAVSAVAQQVLWNCLIEDPALVLRHFLEKLTISNRQDELIYMLRKLLLNIGDLPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFLKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEAVLKECLEFFNIPEAQSSNYFLMDKRWNLIHYAKTYVRDIYPFRRSVSPQLNLVHMLP.........................EKGQELIEKQVFTRKLEELGRVMFLVSLTQHIPA....AHKQSHVSLLQEDLLRLPSFPRSAIDADFSLFGEHQ.GKELFGLDTLHKSMWIKLLEEMFLGLPSEFPWGDEIMLFLNAFNGALILHPEDSALLRQYSATVINTAVHFNHLFSLSGYQWILPSMLQVYADYESNPLLRHAIEFACRQFYILHRKPFILQ..........LFASVAPLLEFADVTSSGS..SKGVSSQCLFDLLVSLEG.DTRDILDVLELVKAEKPLKSLDFCYGSEDLVFSIHEGIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKKQTIQLETASAGREEITSIGCLATSLQALLYSVESLTRPMTAPQMSR..SDQGHKGA.PTANHAMSGG...GNT.SPGQGWYILGT.....SLINNLHL....LEEG...HGLPT.....EELDERIAREEFRRPRESLLNICTEFFKHCGPRLK..ILQNMAGEPRLTAL.ELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASSLIEGICLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNN.ERREGMLLNLLIPFVLTVGTGSK.DSPKLEQPEVLLLLQTVINILLP..PRIISTSRSKNFM......LENSPAH.CSTPGDTAKDLRREG.....LAESTSQAAYLAFKVILVCFEHHLGSQWYRLSLQIKEMAMRRVGGLAMWDFIDFIVRTRIPIFVLLRPFIQCKLLSQPAENHEELTARHHITDQLERRFIPRPLCKSSLIVEFNNELKILKEAV
A0A1D2NM70_ORCCI/1993-3075             GVTVTTGVVLTKSNAPKAHAMFPSSLGSAAVFITQLLDDPAVTLDGHAVYEVAYQVLWNCLVEDSSLFLRYVFEKLT.RGRHELMFKVLRHIILFVPRLPQQAAFALYNHIIGFIMFHTRSPQDASTEMIGSALSVLWMVV.HSVQGIMFKDLKQTLRKEQ..CDSSILLTANVPAAKKIVVHGPFGPESGGIPTQFPVQEDTQFVQILREAYDFFSIDEEHHKEYFLVDHKTHQIHNPNSYVRDFYFFSRAAHPQLSLTHMAP.........................DHAYNALQRQSFILKFLESGKVTLTWAILKNV......DQVMQRVVFLHEELMKLPSFPRKALESDIDICKGGMMGRELLGLDVLHKFMWTKLITRMFEAMTGNFAYSGDIHLFLNVLSGSLLVHSEDATIIRYVIAAFINAAQQFKNIFSTNGYLLVMPPLLLTYCNHQSNPLVTGSVEFAVKEFYLLHRKPFVLQ..........MFGALAALLDTDEQAQYGD..PTRVPSKCLFRLLLSLET.PTPDPLHITELIHGPQPLRPLDFCYHDDSDEITVLDCISMCVCVVAYASDSLRGQQMLTILEAVLPPYLTHIQTNKTE......GKTERDIINHIAVAMKTLVNNCEPLAKNYSGPQMSS...PADLRGS.SQRNYTSKGG...IMT........PGYE.....FADDDSHS..KYMSDP...SRNKQSAYDRDMQDSEVIRDEFRRPRDTLLCLVSDFYSKSSARLP..ELAK.KGGAEAKPV.ELLDLRSHTRLAEVSMSLLKVSPYDPPTMGCRGLQKYMVEVFPYGEWTHEGSRTTLTAFLRRLDKTFIKICKKPSI..........RRHTDWEAAAGLLKGIYQMLWRHPHIVHNQHLKSLITTCECLLMGEGQA....SELGLSTAGQ.....ALMGK.........IPP...THFCSTVVRLLALQVRALGETYSLEQACGVQYTLASPLDKSDVLLMHLLIPMCLRVGTGRKADVPKMRKTDIVYILNVILTSLNTGGPRIKSTAESNSTS......IIGGIGG.ASGTTRSG.SVTERK.....LKQSTCQIAFLGLKILCVCFDSELSSEWPRTVRVIQEMGNRGEGGAALWEYLEFVVTVRSSIFPMCRPLIAHKLSLPPTNDQERHY.QFVIREKLKEIVLPK..CKGLLLLDLAHQVKQLKEDL
A0A2R2MLL0_LINUN/1431-2537             GEEERVEVLHSHQV.QMAQPVFPSVICTASVPIIHLLEDVEVSTEGISVCEVAEKVIWLCLVEDPALFLRHFLEKMTNKDKQEELIFVLRKLLLMLPSLPSQTGHILFNYLVGYIMFNVRAPSEGTVESTSRVLSILWMVI.PYVDGIFFKDLKQTLKKEQ..CEPQLMVTANVPSAKKILIH...GPDLTSIPSQLPVHEDTQFCTLLQDSLDFFNIPEEQHAEYFLVDVRTNQIHNGNSYVRDFYFFKRNQYPQLSMVHMNPNDAYGKLQMQKTEIYPELAMVRLDTQKAFSALQHKAIALKFAEVGKVMATFSILTSHQTPGRSHQLQNHVMFVYEELLKLPSFPRKALEAEFGMYKGDH.GKEMSSVDSMHKYTWIKLVDKLFACMTGTFGWSGEIPFFLNVINGALLLQCEDTALFRFCIATLINAARKFKHIFATDGFLYIMPTIMRVYSNNQNNPVLVRGVQFACKQFFILHRKPFVLQ..........MFGSIASSLNVGPLFATPT..GNKIPAKHLFEMLLALEG.DCPDEMDILELVEGEMPLKALDFCYADEPDSLTMLECINMCVTVVAYASDSVRGAQMLTILDALLPQYLQHIRPAKKNHEK...AKEELNIIMNLGVSMRALITSCDALTRNMSGQQKHL...EVVSSGA.KPVKAHMGNHL..FAD...................RDSVDLNTRQMEEG..TRTTPQ.....QREDEDLEISEYRQPRDSLLCVAAEYYTTCVPRVK..ELRKQLSDSNRNV..ELFDIKAHTRLAEIAHTLLKLAPYDPCTMGCRGLQRYMVQVLPLTDWSHEKIRPALHLLLKRLDRMFNKVTRKFTL..........KQNFDWFAAANLLRGLYLTLSNYPSLAFIPYMKPVINVCLGILLSEDKP........EGTQST.....QHNSF........AAQV..PQLFCSSVVKLVAMQMAALGDQYTLEQVCGG.SVYTSM.EKTQNVLMNFIVPLCIRVGAGRK.DCPKVRQEDISYALTIILNTLVP..PVKVPVQPVGGFNKP..HYMSASDVH.NSSVSYSEARSPQSA.....IKENVFDTAFLGLKVLIVCFPKELSLEWQRIANCIKEIGHKMIGGAALWRFMDFVVTIRSPLFVLLQSFIKYKLTKLPCETEIEFQLQQLVASKVKSFSLAPPKSTGTILIELANELRQIKEEL
R7T6S3_CAPTE/1812-2911                 GDEERVEHMHSHHM.QVAQHFFPSSICAAALPIIHLLEDLEVNLDGVAVSEVAEKVIWNCLVEEPTLFLRTFLEKITQRDKQEELIFLLRKLLYHLRELPAQTAHCLFNYLVGFIMFYVRSPAEGGTEAVGQALSVLWQVV.PSVNGIYFKDLKQTLRKEQ..CDPSLMITANVPSAKKLIVH...GPDLSSIPSQFPILEDTQFSQILEDSLDFFNIPEDQQHTFFLVDTKSNQMHTSNSYVRDFYFFRRNFYPQLSLVKMDP.........................EEASKNLQNQAFMLKMLEMGKALFSLSIL............QNHVSFLQEEMLKLPSFPRKALETEFGLHHGDG.GKEVFGMDMLHKYVWTRLMSNMFRGMSSTITYAGDLPLFLNVINGTLFLHGEDIAMLRLCLATLINAARHFKQVFSTSGFLFIMPTILRVYSNHQCNSMVCHAIEFVCKQFFILHRNPFMVQ..........MFGSVAPVLDVGGKPGSKD..CHKVDPEALFNLLLNLEK.DQEDILDLLELVDGEKPLEAMDFCYIDDPDTFTLLDAINLCVTVTAYASDSVRAMQMLTILEAILPYYLKHLKENTAREETPQALRTELSLISSVGVSIRAMIGGAEGLTRNFTGPQRQLESCNSNSKSAQNHTNHSPQGPTIYCDE...................VSDIRF..MHMEEGLAKKKQSHISSSAPDTEADVTLKEFRRPRDAILCVVADYCSHCSSRIP..ELRRLLADPSLRCP.EILDHKAHNRLADFAHTLLKIAPYDPPTMRSAGIQRYMVEILPTTDWSQDSIRPALHLLLRRLERLFSKIYKKPVL..........RRHIDWDSAANMLKGVYITLSKFAFVAHLPHLKTLINVCLNIVLANEGG....MTVGDAFHQPTAGGGHIGKM........AAPP....LFCSAAVKLAALQMQALGDQFSLEHMCGGMSAFPTP.EKTANMLLSLILPLCIRMGCGRR.DYPKMRQTDIHFALTLVLNALIP..PRKHHGVSNSAALSGAMGMPKSNSMS.MGEIGRTGSLSSGHGKQINTPKEVLQNVAFLGLKILVVCFNKQLSSGWHRIATVVSECGSALNGGIPLWRFVDFVVTIRTPLFMMLQPFIQYKMMKSTCETEQEYFIQQNVHQKLQGLNMPHPKCKASILVELAAEMRHLKEEL
A0A2T7NMQ5_POMCA/1838-2924             GEEERADHS...HHLQTAQAFFPSCICAAVLPVLHLLDDHDVNTEGVSVSEVANKIIWDCIVDDPILFLRHFLEKLTNKERQEELIFLVRKLVIYFRQLPAQTAHSIFNYLVGFVMFYVRSPCEGGQDAIAGALSLLWLVV.PCVEGIYFKDLKQTLKKEQ..CDPYLLVCANVASAKKILVH...GPDLSSIPSQLPIHEDTQFSHILQESLEFFNIPEDQHHCYFIADTKTNQVHNQNAYVRDFYFFRRNIYPQLSLVRMDP.........................DDAALALQKRVFLLKFIEIGKVLLTDAVLAN..T....SSHQNHVAFLHEEFLKLPAFPRKALETEFDMYQGQL.GKELFGMDSLHKYAWTKLMTTMFSALNSTFTWSHDLSLFMNVINGTIILLFEDTAILRFCLASLINTCRHFKHIFATNGFMYIMPTLLRVYSNNQPNTVLKQAIHFVCRQFYILHRKPFVLQ..........MFGSVASILDTS.CAAGGMLDCSKVQPDSMFKLLLALDR.ECPDILGVLDLVQGDKPLKALDFCYEADPDTFSMMDTINMCVTVVAYAPDSFRSVQMLMILELVIPRYLEHLCQETTHRDSVSMARSEVTAITNIAVALRALISCSEYFARSMSLPQRFM...ESSSVGK.PIRNHSMHSLT..VDD...................CEDSHT.SHRMEEG...RRRPH....GVDAEEFEMREEFRHPRDLILSIAAQFWTTCHARLR..QLRKILGDPSFRPP.ELLDHKTHNRLAEIAHTLLKLIPYDPYTISCSGLQRYMLEILPNTDWSQELVRPALNLILRRLDRLFTKISKKNAL..........KRQIDWEAAANILKGVFQTLKKFAYIAYLPHLKTLVNVLISILLSSMGGLSVSLDPGLGTQST.....NRTER........SSSPEVAPVFCSAVIKLVAMQMQALGEHYSLEYICGGPSAVHPS.DKLLGLLTNFVLPLCIRVGCGCR.DMPHLYPVDIKFVLNAVTSLLTP..HPPAATMHNSSTK.S..HYVNTERSR.SGSMSASEKMAQKLG......HEFHHTAAFIGLEVLAVCFDKHLSTEWQSVAKCIQALASKGKVGLPLWKFLDFLVTHRPSLFLLLHTFIRFRMMRVNCDTAQEYYMQQTIKDKLQGYSYAYPKSTATILISMAQELKQLRDNM
A0A210PLR2_MIZYE/1971-3067             GEEDRTEHT...HHMQLAQTFFPSCICATALPILHLLDDQDVNADGISVAEVAEKVIWTCIVEDPILFLRHFLEKLTHKDKQEELLYLLRRMVLYFQDLPAQMAHSLYNYLTGYVMFYVRSPCSGSQEAIAGALGLIWQVI.PSVDDLYFKDLKQTLKKEQ..CDPYIMISANVPSAKKIIIH...GTDQTGIPSQLPIHEDTQFSQILQESLDFFNVPEDEYSSYFLVDTKSNQIHNLNAYVRDFYFFRRNVYPQLSLVKMNP.........................DHAFQSLEKQAFILKFVEIGKVLFTHSVLKSTAP....HQMQNHVSFLHEEFLKQPSFPRKALEAEFGLYHGKS.GEELYGLDTLHKLSWVKLMSAIFSKMTSTFSWTNDLQLFLNVINGCMILHCEDTALLRFCLSTLINTCRHFKHIFSMNGFLYLMPTLLKIYSNNQPNPVLCQAVEYVCKQFYILHRKPFILQ..........MFGSVTPLLDMT.SEDTGLVDCRKVQPDCLFKLLLSLER.DTVDSLCILELIQGEKPLRALDFCYENDPDRLEMIEVINMCVTVIGYAPDSFRSVQMLTVLEVVVTRYLEHLRLETTRQDNPPAARAEITIITNMGISIRALLSCCEYFTRNMSLPQRQLE.SDKPNVKS.NQSNHSPLGGTSYYDD...................REDSHASCRHMEEG...RKKAY....TQDSEDMEMRTEFRKPRDSLLSVVAEFYASCQSRLK..ELRKMLQDPSFRPP.ELLDHKTHNRLAEIANTLLKLAPYDPDTLRCTGLQRYMTEILPITDWKQEAIRPGLNLILRRLDRLFIKISKKTAL..........RRQADWDAAANLLKGVFLTLKKFQYIAHLPHLKTLIGAVLSIILSGPGG....AVLPDNLFSF.....HGSHRIEHITQSILTPP....SFSSAVVKLVAMQMAALGEQFSLEQICGGMAEFPTP.ERYINILVNFILPLCVRLGCGRK.DTPKMNTEDVKFALQVSLNVLCP..PIKIRSQQQGNTKSTTLHHLSISENHRCSSYGQLDKGFKHEN.......EMLLHTAYLGLEILMTCFDKVLSTEWHKVTHCIQNLGCKSKVSLPMWKFLDFVVTYRPSIFLLLQPFIRYKIMRINCDTAQEYYIQQTIKDKMLGYSFTHPKCNASILLQLAVELQALKDEF
K1R226_CRAGI/1972-3055                 GEEERAEHL...HHMQQAQTFFPSCICAAVLPIIHLLADGDVGGDGVSVNEVAEKVIWNCMVEDPVLFLRHFLEKLTHRDKLEELLFLMRKLVLHYRELPAQMAHALYNYLIGYVMFYVRSPCAGSQEAIAGALALIWQVI.PSVDGIYFKDLKQTLKKEQ..CDPYILISANVPSAKKILIH...GPDEASIPSQLPIHEDTQFSQILQDSLDFFNIPEEDYPLYFLVDTKSNQIHNLNSYVRDFYFFRRNFYPQLSLVAIDP.........................DNAMASLERQAFTLKFVEIGKILFTTNVLKSTPL....HKIQNHVSFLHEEFMKLPAFPRKALEAEFSLYND.......................TLFSSMTSSFGWNNDLQLFLNVINGCIILHCEDTALLRFCLASLINTSRHFKHIFSMNGFMHIMPTLLKTYSNNQPNPVLCQAIEFVCRQFYVLHRKPFILQASHHKVLAKEMFGSVATMLDLT.SKETGMIDCRKIQPDCLFKLLLSLEKPDCADNLSILELVDGVKPLQALDFCYENEPDRLTMIEVVNLCVTVIAYAPDSFRSVEMLTILEVVVSKYVHHVRSETIRVDKPHAAQAEVSAIIDVGIAMRALISSCEYFTRSMALPRQIE..NEKANPKS.VTSNHSPLGGTSYYDD...................REDSHI.SRHVEEG.....RKR.....QETEDTELTNEFRKPRDLFLNVIAEFYSTCQPRLKCNELRRMLVDAASRPPTELLDHRSHNRLAEIANTLLKLAPYDPQTLSCTGLQRYMTEILPLTNWKQEAVRPGLNLILRRLDRLFNKISKKSSL..........RRQADWNAAANLLQGVFYTVRRHQDLANYQHTKTFVNALLVIVLAGPGA....PVLPETTSGI.....HGSHRSEYGAVFHIVPP....TFCSAVVKLVAMQMQALGDQFSLEQICGG.SVFASH.DKCINMLVNFILPLCIRLGCARKGDTPKLRADNVTFALTVILNILCP..PARNPQQQQNSSSKSTIHHLSFSENHRCSSFSQSDKIHRPEN.......QLLLNVAYLGLEILMVCFDRILSSEWHKVTKVIQDLGSKGKVSLPLWRFVDFLVTHRPSCFLMLHPFILYKMMKINCDTAQEYYLQQAIKDKMQGFSFSHPKCSATVLLQLAVELQHLKEEF
A0A3M0L5T6_HIRRU/1755-2815             DEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPETQSSHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVQMHP.........................EKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPP....AHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIKLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWVLPSMLQVYSDYESNPQLRQAIEFACRQFYVLHRKPFVLQ..........LFASVAPLLEFPDATNNGT..SKGVSAQCLFDLLQSLEG.DTPDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVDNGTAAREEIASMGALATSLQALLYSVEVLTRPMTAPQMSR..CDQGHKGT.TTANHTMSAG...VNTRYPEQGAKLH.......FIRENLHL....MEEG...QGLPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNLAGEPRVTSL.ELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEPASSLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQKF.......ILC.....FRED.DRVAQ...................DSPWLEQPEVLLLLQTVNNILLP..PRIISTSRSKNFM......LESSPAH.CSTPGDAGKDLRREG.....LAESTSQAAYLALKVILVCFERQLDSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELTARQHISDQLERRFIPRPLCKSSLIAEFNNELKILKEAV
A0A2K6H0C3_PROCO/1864-2867             DEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQ...........VNSSSF...........LVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGNP....................................YFLTPSTECFRDFLFNT...........IR.....RKTIDP.LKSQQLPD.........................EKGDIRTEIRVFTRKLEEVGRVLFLISLTQKIPT....AHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWILPTMLQVYSDYESNPQLRQAIEFACHQFYILHRKPFVLQ..........LFASVAPLLEFPDAANNGP..SKGVSAQCLFDLLQSLEG.ETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSR..CDQGHKGA.TTANHTMSSG...VNT...................RENLHL....LEEG...QGLPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNLAGEPRVTAL.ELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPWLEQPEVQLLLQTVINVLLP..PRIISTSRSKNFM......LESSPAH.CSTPGDAGKDLRKEG.....LAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELSARQHIADQLERRFIPRPLCKSSLIAEFNSELKILKEAV
A0A384BT73_URSMA/1944-3031             DEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVHMHP.........................EKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPT....AHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINSAVHFNHLFSLSGYQWVLPTMLQVYSDYESNPQLRQAIEFACHQFYILHRKPFVLQ..........LFASVAPLLEFPDAANNGP..SKGVSAQCLFDLLQSLEG.ETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSR..CDQGHKGT.TTANHTMSSG...VNTRYQEQGAKLH.......FIRENLHL....LEEG...QGLPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNLAGEPRVTAL.ELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYVMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPWLEQPEVQLLLQTVINVLLP..PRIISTSRSKNFM......LESSPAH.CSTPGDAGKDLRREG.....LAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELSARQHIADQLERRFIPRPLCKSSLIAEFNSELKILKEAV
A0A2I2YAW1_GORGO/1815-2902             DEEHTTEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISNRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVHMHP.........................EKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPT....AHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQAGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHFNHLFSLSGYQWILPTMLQVYSDYESNPQLRQAIEFACHQFYILHRKPFVLQ..........LFASVAPLLEFPDAANNGP..SKGVSAQCLFDLLQSLEG.ETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSR..CDQGHKGT.TTANHTMSSG...VNTRYQEQGAKLH.......FIRENLHL....LEEG...QGLPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNLAGEPRVTAL.ELLDVKSHMRLAEIAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPWLEQPEVQLLLQTVINVLLP..PRIISTSRSKNFM......LESSPAH.CSTPGDAGKDLRREG.....LAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQCKLLAQPAENHEELSARQHIADQLERRFIPRPLCKSSLIAEFNSELKILKEAV
W5MBC6_LEPOC/1872-2867                 DEENATEHTPTHHVLQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPALVLRHFLEKLTVSNRQ...........VRQKDLTLFPNTSLYLYNIIYVLHHCLCIALKDLHHYSQRITLRRNVITSSLENVLFRSIEGVLIANDGWAMNALTGCVVAPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPEARSAHYFLMDKRWNLIHYSKTYVRDIYPFRRSVSPQLNLVHMLP.........................EKGQELIQKQVFSRKLEEVGRVLFLISLTQHMPA....VHKQSHVSLLQEDLLRLPSFPRNAIDAEFSLFSEPQ.GTFPSSTKRVHR......LAHFFKGGQTE...........................................NISELSSWKPVREGDISKAGRYPSNSHI.EGKCLIIMIICVIRLEPVIRV..................................VPVQAMF...................FIEAHKFHHLADFCYGNEDLAFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCFLQKLKKQTEALESASAARDEIAAIAALATSLQALLYSVEALTRPMTAPQMSR..CDQGHKGA.TTANHTMPGG...GNTRCVRLLYLLSVQSGEIAFKRDNLHL....LEEG...QGMPR.....EELDERLAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNVAGELRVTAL.ELLDIKSHMRLAEIAHSLLKLAPYDTLTMESRGLRRYIMEMLPITDWTTEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASSLIEGICLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKDDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPHLEQPEVFLLLQTVINILLP..PRIISTSRSKNFM......LESSPAH.CSTPGDTGKDLRREG.....LAESTSQAAYLALKVVLVCFERQLGNQWYRLSLQVKEMALRKVGGLALWDFIDFIVRTRIPIFVLLRPFIQCKLLTQPAESQEEITARHHIADQLERRFIPRPLCKSSLIAEFNNELKILKEAV
A0A4U5TVT9_COLLU/1744-2818             DEENTTEHTPTHHMLQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQILWNCLIEDPALVLRHFLEKLTVSNRQDELMYMLRKLLLNIGDLPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPEARSAHYFLMDKRWNLIHYSKTYVRDIYPFRRSVSPQLNLVHMLP.........................EKGQELIQKQVFSRKLEEVGRVLFLISLTQHMPA....VHKQSHVSLLQEDLLRLPSFPRTAIDAEFSLFNEQQ.GKELFGLDTLHKVLWIKLLEEMFLGMPSEYPWGDEMMLFLNVFNGALLLHPEDSSLLRQYTATAINTAVHFNHLFSLSGYQWILPTMLQVYADYESDPLLRQGIEFCCRQFYILHRKPFILQ..........LFASVAPLLEFTTSTSTGL..SKGVSAQCLFDLLVSLEG.ETQDALDALELVKAEKPLRSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCHLQKLKSNTVTMESASAARDEIAAIAALATSLQALLYSSEALTRPMTAPQMSR..CDQGHKGG.TTANHAMSGG...VNT...................RDNLHL....LEEG...QGMPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNVAGEPRVTAL.ELLDIKSHMRLAEIAHALLKLAPYDTLTMESRGLRRYIMEMLPITDWSSEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASSLIEGLCLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPHLEQPEIFLLLQTVINILLP..PRIISTSRTKNFM......LDASPAH.CSTPGDTGKDLRREG.....LAESTSQAAYLALKVVLVCFERSLGNQWYRLSLQVKEMALRKVGGLAFWDFIDFIVRTRIPIFVLLRPFIQCKLLTQPADSQEEITARHHIADQLERRFIPRPLCKSSLFAEFNNELKILKEAV
A0A2I4BUX5_9TELE/1914-2988             DEENTTEHTPTHHLLQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQILWNCLIEDPALVLRHFLEKLTVSNRQDELIYMLRKLLLNIGDLPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFDALLKECLEFFNIPEARSAHFFLMDKRWNLIHYNKTYVRDIYPFRRSVSPQLNLVHMLP.........................EKGQELIQKQVFSRKLEEVGRVLFLISLTQHIPA....VHKQSHVSLLQEDLLRLPSFPRTAIDAEFSLFNEPQ.GKELFGLDTLHKVLWIKLLEEMFLGMPSEYPWGDEMMLFQNVFNGALLLHPEDSALLRQYTATAINTAVHFNHLFSLSGYQWILPTMLQVYADYESNPLLRQGIEFCCRQFYILHRKPFILQ..........LFASVAPLLEFTTSTSTGL..SKGVSAQCLFDLLVSLEG.ETQDGLDALELVKAEKPLRSLDFCYGNEDLAFSISEAIKLCVTVFAYAPESFRSLQMLNVLEALVPCHLQKLKSNTVTMESASAARDEIAAIAALATSLQALLYSSETLTRPMTAPQLSR..CDQGHKGG.TTANHAMSGG...ANT...................RDNMHL....LEEG...QGKMR.....EEMDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNVAGEPRVTAL.ELLDIKSHMRLAEIAHALLKLAPYDTLTMESRGLRRYIMEMLPITDWSSEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASNLIEGICLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPHLEQPEIFLLLQTVINILLP..PRIISTSRTKNFM......LDASPAH.CSTPGDAGKDLRREG.....LAESTSQAAYLALKVVLVCFERSLGNQWYRLSLQVKEMALRKVGGLAFWDFIDFIVRTRIPIFVLLRPFIQCKLLTQPAESQEEITARHHIADQLERRFIPRPLCKSSLFAEFNNELKILKEAV
A0A6A5DTX8_PERFL/1696-2770             DEENTTEHTPTHHMVQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQILWNCLIEDPALVLRHFLEKLTVSNRQDELMYMLRKLLLNIGDLPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVV.GYVEGLFFKDLKQTMKKEQ..CEVKLLVTASMPGTKTLVVH...GQNECDIPTQLPVHEDTQFEALLKECLEFFNIPEARSAHYFLMDKRWNLIHYSKTYVRDIYPFRRSVSPQLNLVHMLP.........................EKGQELIQKQVFSRKLEEVGRVLFLISLTQHMPA....VHKQSHVSLLQEDLLRLPSFPRTAIDAEFSLVNEPQ.GKELFGLDTLHKVLWIKLLEEMFLGMPSEYPWGDEMMLFLNVFNGALLLHPEDSALLRQYTATAINTAVHFNHLFSLSGYQLILPTMLQVYADYESDPLLRQGIEFCCRQFYILHRKPFTLQ..........LFASVAPLLEFTTSTSTGL..SKGVSAQCLFDLLVSLEG.ETQDALDALELVKAEKPLRSLDFCYGNEDLAFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCHLQKLKSNTITMESASAARDEIAAIAALATSLQALLYSSETLTRPMTAPQMSR..CDQGHKGG.TTANHAMSGG...VNT...................RDNLHL....LEEG...QGMPR.....EELDERIAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNVAGEPRVTAL.ELLDIKSHMRLAEIAHALLKLAPYDTLTMESRGLRRYIMEMLPITDWSSEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASNLIEGICLTLQRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALKEDFPLSHVI...SPFTNQ.ERREGMLLNLLIPFVLTVGSGSK.DSPHLEQPEIFLLLQTVINILLP..PRIISTSRTKNFM......LDASPAH.CSTPGDTGKDLRREG.....LAESTSQAAYLALKVVLVCFERSLGNQWYRLSLQVKEMALRKVGGLAFWDFIDFIVRTRIPIFVLLRPFIQCKLLTQPADSQEEITARHHIADQLERRFIPRPLCKSSLFAEFNNELKILKEAV
#=GC seq_cons                          DEEpsTEHTPsHHhhQPPQAVFPACICAAVLPIVHLhEDGEVREDGVAVSAVAQQVLWNCLIEDPuLVLRHFLEKLTlSNRQ-ELhahLRKLLLplsDLPAQTuHhLFNYLVGhIMaaVRoPCEhGhDAISusLThLWpVV.uYVEGLFFKDLKQThKKEQ..CEspLLVTAshPGsKpLVVH...GpsEssIPTQLPVHEDTQFpslL+EsLEFFNIPEspsscYFLhD+RhN.IHhspoYVRDhY.FRRoVsPQLsLV+MtP.........................EKGpchlQKQVFoRKLEEVGRVLFLlSLTQ+hPs....sHKQSHVShLQEDLLRLPSFPRsAIDAEFSLas-sp.GKELFGLDTLHK.hWIKLL-cMFhGMsSEFsWucElhLFLNVhNGALlLHsEDoALLR.hhATlINTAhHFpHlFSLSGYpaIhPThLpVYucYpSNPlL+QuIEFsC+QFYILHRKPFlLQ..........hFuSVAPLL-hssssssG...u+tVsuQCLF-LLlSLEG.-TsDhLDlLELV+AEKPL+uLDFCYGNEDLsFSIpEuIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKLKppTsphEossAAR-EIuAIuuLATSLQALLYSsEsLTRPMTAPQMSR..CDQGHKGu.oTANHoMuGG...sNT...................R-NlHL....lEEG...pGhPR.....EEhDERlAREEFRRPRESLLNICTEFYKHCGPRLK..ILQNlAGEPRlTuL.ELLDlKSHMRLAEIAHoLLKLAPYDT.TMESRGLRRYlhEMLPITDWosEAVRPALILILKRLDRMFNKIHKMPTL..........RRQVEWEAASNLIEGlCLTLpRQPIISFLPHLRSLINVCVNLVMGVVGP....SSVADGLPLL.....HLSPY........LSPP...LPFSTAVVRLVALQIQALtEcFsLpaVh...SsFTsp.ERp-GMLLNLLIPhsLpVGoGsK.DSP+LEQsElhLLLQTVlNlLLP..PRIISTSRoKNFh......L-uSPAH.CSTPGDoGKDLR+EG.....LAESTSQAAYLALKVlLVCFERpLuoQWY+LSLQVKEMAhR+VGGLALWDFlDFIVRTRIPIFVLLRPFIQCKLLsQPAEopEEloARpHIuDQLERRFIPRPLCKSSLlsEFNsELKILKEAV
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