# STOCKHOLM 1.0 #=GF ID CTD6 #=GF AC PF20282.1 #=GF DE C-terminal domain 6 of the ABC-three component (ABC-3C) systems #=GF AU Chuguransky S;0000-0002-0520-0736 #=GF GA 26.4 26.4 #=GF NC 25.2 23.7 #=GF TC 27.5 30.6 #=GF SE Aravind L #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 32894288 #=GF RT Comprehensive classification of ABC ATPases and their functional #=GF RT radiation in nucleoprotein dynamics and biological conflict #=GF RT systems. #=GF RA Krishnan A, Burroughs AM, Iyer LM, Aravind L; #=GF RL Nucleic Acids Res. 2020;48:10045-10075. #=GF DR SO; 0000417; polypeptide_domain; #=GF CC C-terminal domains (CTDs) of ABC-3C systems, contain distinct #=GF CC patterns of charged and polar residues and are not yet unifiable #=GF CC with known domains. These domains are found at the C-terminus of #=GF CC the effector component of the systems, which are upstream of the #=GF CC Middle Component and ABC ATPase components on the genome. Due to #=GF CC the typically large size of these CTDs relative to the actual #=GF CC effector and MC domains, the CTDs are predicted to serve as the #=GF CC platform on which the remaining two components assemble. #=GF CC Therewith, conformational changes transmitted by the ABC #=GF CC ATPase-mediated detection of invasive elements like DNA viruses #=GF CC would result in an unfurling and activation of the #=GF CC CTD-associated effector [1]. #=GF SQ 18 A0A140L209.1/198-333 EMVYVRELLAAYADAEGLDELPKESLESF.P.KYAKDFKRRRKDYYAAESIRRGARDVFGETTpdQFDVLKEETYDGIIDVYEN.EYPHGLARLKGVMSQAALIRVDKCVYsqiPNWIGASEKKGVCHILVNDGK.LRgW A0A4R2P5V1.1/232-360 ESRYIRQLLDAYGDQLGAAMTDPVALDAH.A.PIKRDFLRQRERFYHAESLRNFARDTVPEG-..TFAALQNEVCHGVIDICEG.HHQDGFERMRATLTQAASLSLTANPL...SSVTKKQDCQGICHQLANDDR.LT.W A0A2P1PZQ6.1/232-360 ESRYLRQILDAYGDHLGVTLSDVAALDPH.V.TLKRDYLRQRERFYHAESLKNFARDNVPEG-..TFDALQEEIYQGVVDICET.AHTDGLARMKATMTQAAAIHAASNPL...FPALKTQDRQGICHHLANEDR.LL.W A0A1M7TNX0.1/238-367 ESRYIEQLFEAYSDHKSCSLSTINCLSPW.P.NLANHLQRQREYFYYAESLRNFARDSVPVG-..TFEELQGEVHAGVVDVAESsQHKDSLDRVNAVTSAAISMQLTSNPL...IQVTKAQDRKGICHQLANEDR.LI.W A0A011QNE4.1/234-362 ETRYVEQLLAAYSDETGQNFHVVGDLSG-.S.KYEADLHRQRERFYSAETLRRFARDNQPSVA..PYEDIAAQMYYGVIDCVLK.NFPSGYQRMLETMTTSAKIVISNHPL...RSYLKPQSKQGICHQLANDDR.VH.W A0A142Y7D4.1/230-357 EITYIRHLLEAYGSHLNRVIERLDDLSD-.D.ELKAHLLDSRREFYSAESLRAFSRDTLPPG-..EFEVLQDELHSGICDEVRG.EHSNGYHRVLAVVRVARSLQLTAHAL...VSRLTVRDRGGICHQLANDNK.LR.W A0A1C0BUT5.1/195-328 EEKYVSELLAAYAEAIKSGNLTKADLDSL.PtKFKRNFSDQRINYYSALRIDRFIRESIDKGE.eHSKKWKSETHDYIKDTLWD.DYDDGYKRLLAVMKKVVDCSTTSVVDn.iQNLVGPKEKKGTCHLLVNDGC.VR.W A0A4D6BBY0.1/195-328 EEKYVSELLAAYAEAIKPGNLTKADLDSL.PtKFKRNFSDQRINYYSALRIDRFIRESIDKGE.eHSKKWKSETHDYIKDTLWD.DYDDGYKRLLAVMKKVVDCSTTSVVDn.iQNLVGPKEKKGTCHLLVNDGC.VR.W D2RKA3.1/168-302 EKQYIEELFRAYGDAENLPMFSATDLDKY.P.DYFEDLNDRRIDFYAAVSIQRGVLELHGKNLanQFDVLKEEVLDGVKDTVRK.SHPNGYERMLSVMELAVALPVPNYLLsssPFWISGKIKKGVCHHLVNDHK.IR.W E3I1Y3.1/244-373 ETVYVHQLFKVISNEIGAPVSGTADFVQF.Q.NFRSLFDRSRITFYCAEGLKELARDQMADVK..FFDTLLTEFCDGLFHWYSD.STATGFQRLTRTVKGAQQLQLGTHLL...AQHVLANDREGMCHQLANEGL.VR.W R7GCH9.1/189-324 ELPYVKELLKVYSEKIGVKINSSNDLNQY.K.DCMFHFNRQRRSYFSAEAIKRSVRDLFADGQ.dNFKLIQNEMFSAVEKVYFNvDTKDGYTRLSNVLNMALKANLNSTILlniRGLITAEERKGICHILVNDGV.IHsW Q4FVR4.1/217-346 ESEYLKKILQAYSDFNKQDISTIDDVTD-.I.DLTEHYKDSRIQFYSAEALKRFSRDALPEN-..EFKLLQQEFLNGIKDEIRNpVHANGYLRLLEVVKVARALQITSHAL...IDCLMVNDRGGICHQLANDNEsIA.W Q3Z7H9.1/178-313 EADYISALCDAYAEVLSRDSVTMDDIPTL.PkKYQTNFYDQRKAYLSAESIQRSISEVYEDGE.nQFDILKSDAFDGIKTTYLD.DYDNGYRRLLEVLKKISDVQLTKSKLsliKNLIGNLERLGIVHILVNDKT.IKsW R6QYS4.1/181-313 ---YINELIKVYSKLSGHLINNVEDLKNY.P.EYENHFNEQIKCYYYAENMRNSIKTLFSDGE.eHFNILKEEIFDSIYETYEDlSQINSYQKLKNVLEMVIKATLNSSILlniKGLITTKEKKGICHILVNEGR.IRsW A0A1H4LCE1.1/244-372 ENQYVAQLLTVVAKDLGQPVSGLADFLHS.D.KHRKLFDRSRLTFYCAEGLKELARDQMADKG..YFDMLFDEFSDGLYHWYTG.-SPDGYDRLVSTIKAAQSLQLSAHAL...TPHVVPNDREGMCHQMANDGR.VE.W A0A6N6QF50.1/35-162 ELPYIQGLLEAYGEREGAVFADHNAADAH.A.LHGPHLRMQRERYFDADAFTRFYRDNTTAK-..DTDDLRKEILHGIYETHTA.KHDDMLSRINAVMIQASNTQ-PAGPL...AKYARTPVKQGICHHFINEGQ.LK.W Q89Z46.1/215-347 ERNYIQNLNDAYSEHAGYIINVIDDDNAVvS.KYRKHLDRARISFYESEEVKIASRKSTAPDS.dEFNDLVTSIERYIGNELDD.DYPDGFTKVKSVEKKAGTYNMPTSML..iSHLVDSNVCVGVCHQLSNENR.IK.W G9PCN0.1/1-64 -----------------------------.-.-------------------------------..--------MHAGVSDTNLR.QYPNGLERLLATLAQAAAVQLDGVRLdqiIDLIDVWSRKGSCHELVARNR.LG.W //