# STOCKHOLM 1.0
#=GF ID CTD6
#=GF AC PF20282.1
#=GF DE C-terminal domain 6 of the ABC-three component (ABC-3C) systems
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF GA 26.4 26.4
#=GF NC 25.2 23.7
#=GF TC 27.5 30.6
#=GF SE Aravind L
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 32894288
#=GF RT Comprehensive classification of ABC ATPases and their functional
#=GF RT radiation in nucleoprotein dynamics and biological conflict
#=GF RT systems.
#=GF RA Krishnan A, Burroughs AM, Iyer LM, Aravind L;
#=GF RL Nucleic Acids Res. 2020;48:10045-10075.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC C-terminal domains (CTDs) of ABC-3C systems, contain distinct
#=GF CC patterns of charged and polar residues and are not yet unifiable
#=GF CC with known domains. These domains are found at the C-terminus of
#=GF CC the effector component of the systems, which are upstream of the
#=GF CC Middle Component and ABC ATPase components on the genome. Due to
#=GF CC the typically large size of these CTDs relative to the actual
#=GF CC effector and MC domains, the CTDs are predicted to serve as the
#=GF CC platform on which the remaining two components assemble.
#=GF CC Therewith, conformational changes transmitted by the ABC
#=GF CC ATPase-mediated detection of invasive elements like DNA viruses
#=GF CC would result in an unfurling and activation of the
#=GF CC CTD-associated effector [1].
#=GF SQ 18
A0A140L209.1/198-333 EMVYVRELLAAYADAEGLDELPKESLESF.P.KYAKDFKRRRKDYYAAESIRRGARDVFGETTpdQFDVLKEETYDGIIDVYEN.EYPHGLARLKGVMSQAALIRVDKCVYsqiPNWIGASEKKGVCHILVNDGK.LRgW
A0A4R2P5V1.1/232-360 ESRYIRQLLDAYGDQLGAAMTDPVALDAH.A.PIKRDFLRQRERFYHAESLRNFARDTVPEG-..TFAALQNEVCHGVIDICEG.HHQDGFERMRATLTQAASLSLTANPL...SSVTKKQDCQGICHQLANDDR.LT.W
A0A2P1PZQ6.1/232-360 ESRYLRQILDAYGDHLGVTLSDVAALDPH.V.TLKRDYLRQRERFYHAESLKNFARDNVPEG-..TFDALQEEIYQGVVDICET.AHTDGLARMKATMTQAAAIHAASNPL...FPALKTQDRQGICHHLANEDR.LL.W
A0A1M7TNX0.1/238-367 ESRYIEQLFEAYSDHKSCSLSTINCLSPW.P.NLANHLQRQREYFYYAESLRNFARDSVPVG-..TFEELQGEVHAGVVDVAESsQHKDSLDRVNAVTSAAISMQLTSNPL...IQVTKAQDRKGICHQLANEDR.LI.W
A0A011QNE4.1/234-362 ETRYVEQLLAAYSDETGQNFHVVGDLSG-.S.KYEADLHRQRERFYSAETLRRFARDNQPSVA..PYEDIAAQMYYGVIDCVLK.NFPSGYQRMLETMTTSAKIVISNHPL...RSYLKPQSKQGICHQLANDDR.VH.W
A0A142Y7D4.1/230-357 EITYIRHLLEAYGSHLNRVIERLDDLSD-.D.ELKAHLLDSRREFYSAESLRAFSRDTLPPG-..EFEVLQDELHSGICDEVRG.EHSNGYHRVLAVVRVARSLQLTAHAL...VSRLTVRDRGGICHQLANDNK.LR.W
A0A1C0BUT5.1/195-328 EEKYVSELLAAYAEAIKSGNLTKADLDSL.PtKFKRNFSDQRINYYSALRIDRFIRESIDKGE.eHSKKWKSETHDYIKDTLWD.DYDDGYKRLLAVMKKVVDCSTTSVVDn.iQNLVGPKEKKGTCHLLVNDGC.VR.W
A0A4D6BBY0.1/195-328 EEKYVSELLAAYAEAIKPGNLTKADLDSL.PtKFKRNFSDQRINYYSALRIDRFIRESIDKGE.eHSKKWKSETHDYIKDTLWD.DYDDGYKRLLAVMKKVVDCSTTSVVDn.iQNLVGPKEKKGTCHLLVNDGC.VR.W
D2RKA3.1/168-302     EKQYIEELFRAYGDAENLPMFSATDLDKY.P.DYFEDLNDRRIDFYAAVSIQRGVLELHGKNLanQFDVLKEEVLDGVKDTVRK.SHPNGYERMLSVMELAVALPVPNYLLsssPFWISGKIKKGVCHHLVNDHK.IR.W
E3I1Y3.1/244-373     ETVYVHQLFKVISNEIGAPVSGTADFVQF.Q.NFRSLFDRSRITFYCAEGLKELARDQMADVK..FFDTLLTEFCDGLFHWYSD.STATGFQRLTRTVKGAQQLQLGTHLL...AQHVLANDREGMCHQLANEGL.VR.W
R7GCH9.1/189-324     ELPYVKELLKVYSEKIGVKINSSNDLNQY.K.DCMFHFNRQRRSYFSAEAIKRSVRDLFADGQ.dNFKLIQNEMFSAVEKVYFNvDTKDGYTRLSNVLNMALKANLNSTILlniRGLITAEERKGICHILVNDGV.IHsW
Q4FVR4.1/217-346     ESEYLKKILQAYSDFNKQDISTIDDVTD-.I.DLTEHYKDSRIQFYSAEALKRFSRDALPEN-..EFKLLQQEFLNGIKDEIRNpVHANGYLRLLEVVKVARALQITSHAL...IDCLMVNDRGGICHQLANDNEsIA.W
Q3Z7H9.1/178-313     EADYISALCDAYAEVLSRDSVTMDDIPTL.PkKYQTNFYDQRKAYLSAESIQRSISEVYEDGE.nQFDILKSDAFDGIKTTYLD.DYDNGYRRLLEVLKKISDVQLTKSKLsliKNLIGNLERLGIVHILVNDKT.IKsW
R6QYS4.1/181-313     ---YINELIKVYSKLSGHLINNVEDLKNY.P.EYENHFNEQIKCYYYAENMRNSIKTLFSDGE.eHFNILKEEIFDSIYETYEDlSQINSYQKLKNVLEMVIKATLNSSILlniKGLITTKEKKGICHILVNEGR.IRsW
A0A1H4LCE1.1/244-372 ENQYVAQLLTVVAKDLGQPVSGLADFLHS.D.KHRKLFDRSRLTFYCAEGLKELARDQMADKG..YFDMLFDEFSDGLYHWYTG.-SPDGYDRLVSTIKAAQSLQLSAHAL...TPHVVPNDREGMCHQMANDGR.VE.W
A0A6N6QF50.1/35-162  ELPYIQGLLEAYGEREGAVFADHNAADAH.A.LHGPHLRMQRERYFDADAFTRFYRDNTTAK-..DTDDLRKEILHGIYETHTA.KHDDMLSRINAVMIQASNTQ-PAGPL...AKYARTPVKQGICHHFINEGQ.LK.W
Q89Z46.1/215-347     ERNYIQNLNDAYSEHAGYIINVIDDDNAVvS.KYRKHLDRARISFYESEEVKIASRKSTAPDS.dEFNDLVTSIERYIGNELDD.DYPDGFTKVKSVEKKAGTYNMPTSML..iSHLVDSNVCVGVCHQLSNENR.IK.W
G9PCN0.1/1-64        -----------------------------.-.-------------------------------..--------MHAGVSDTNLR.QYPNGLERLLATLAQAAAVQLDGVRLdqiIDLIDVWSRKGSCHELVARNR.LG.W
//