# STOCKHOLM 1.0
#=GF ID pYEATS
#=GF AC PF20305.1
#=GF DE prokaryotic YEATS domain
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF GA 26.9 26.9
#=GF NC 26.8 26.8
#=GF TC 26.9 26.9
#=GF SE Aravind L
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF CL CL0154
#=GF RN [1]
#=GF RM 32868406
#=GF RT Identification of Uncharacterized Components of Prokaryotic
#=GF RT Immune Systems and Their Diverse Eukaryotic Reformulations.
#=GF RA Burroughs AM, Aravind L;
#=GF RL J Bacteriol. 2020; [Epub ahead of print]
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a prokaryotic YEATS domain. pYEATS is
#=GF CC fused to diverse effector domains, suggesting that the binding
#=GF CC to a ligand activates an effector-based response against an
#=GF CC invasive threat. It has been predicted to specifically recognise
#=GF CC invader-induced modifications of macromolecules by acyl moieties
#=GF CC (e.g. phage-encoded acylations of surface polysaccharides) to
#=GF CC unleash the fused effectors through a conformational change [1].
#=GF SQ 78
A0A5C6DJE3.1/223-297   WDWTIFVKG........PEDVLE.KIEYVEYTL.HPT..F.NN..PVRIIN....ERGHGpyaFPLSTSG.WGTFTV.KVKVY..YKDGTYQRMAHSL-
A0A7I8MZT6.1/149-223   WKWTVFIQG........PTNALD.RIRFVEYTL.HPT..F.PE..RVHEVRq.rgTENRA...FAFSAIG.WGTFEI.RIRAF..LKNGEVQKLSHHL-
D8FFP3.1/472-546       WDWTVFIRA........SRDVLE.QINCVEYTL.HPT..F.PN..PVRTVCr.kgSPDRP...FALSSNG.WGTFTI.DIRVM..MKNGQEKKLQHAL-
A0A509DW66.1/30-101    FHLGVWIDG........NERELD.TITKVEYKL.HES..F.KN..QIRTSE....NRKNS...FSITFWT.WGYFNI.KVTIH..FANGETKFIDHYL-
F2IFK4.1/316-384       -DYGLNIAA........--NVQP.LVDRVTYVYdHSA..F.PN..KYITVS....-SGPH...YQTSYEGpYCLPNM.QAIVY..LKDGKSIKVEFN--
F2IFK4.1/418-492       YNFDIRLRG........VENVKD.RIVKVVYDFnHPT..F.KN..RYITVT....DKTNS...FRVGYDG.WGCLRGlGATVY..FDDNTSKTFSINMC
A0A3Q9G4C9.1/115-189   FRLRIALEG........DNDSDLdRVTRVVYHL.HPT..F.RD..PDRVVT....NRSTG...FELTTAA.WGMFNL.TADVY.vKGSTEPIRLERYLN
A0A0F4K5F5.1/105-179   FRLRIALEG........DSDADLdRVAKVVYHL.HPT..F.RD..PDRVVT....NRSTS...FELTTAA.WGMFDL.TADVY.vKGSSEPIRLERYLN
K2KFM9.1/30-102        YHLGVWIDG........EERDLD.QISFVEYRL.HST..F.TN..PLRRSA....NRRNN...FSITFWT.WGMFQI.EVTLH..LHNGQTQRLSHNLA
A0A0L1JQI4.1/33-107    YHIGVWIES........DDPELMdRVSHVEYTL.HPS..F.PN..RERRSE....NRRND...FSITFWA.WGRFDV.EARVF.vEGEAEPFRITHRLN
A1SVT0.1/30-101        FHLGVWVDA........PERELD.EIEFVEYAL.HPT..F.KK..QNRRSL....NRLNN...FSITFWT.WGIFNI.KVAIH..LHSGEIINMDYYL-
L0DWS9.1/17-89         WRWSVWLDG........SPAELD.DVSHVVYTL.HPT..F.PT..PVRHTD....DRSSD...FRISSAG.WGEFEI.FAEVT..LKSGETLKRHHWLT
A0A4Q7KJ54.1/117-191   YSIRVFLES........DNENDLdRVNKVVYHL.HPT..F.YE..PDRTVV....DRETN...FELRTAG.WGMFNL.TAEVH.lADRVEPLRLERYIN
A0A2R7KMH9.1/358-424   -NVILNLKVs......dPDKREQ.---FVAFFL.HDS..F.SN..EIRFKS....TKNGS...AKLEVRS.YEAFTV.GAYTE..----KGIMLELDLN
A0A2R7KMH9.1/490-556   FDVRIKISS........TNPNKP.LKGDVAFFM.HDS..F.KE..IKFR-K....AIDGI...AKVKVSA.YEAFTV.GAYTE..----DGTILELDL-
A0A2T4UZZ8.1/65-139    WRWTVYIQA........PKDVLQ.RVKCVEYVL.DRT..F.PD..PIREVC....DRGTGaqaFPLKVTA.WGPSTV.RIRVR..FLDGRVQELEHEL-
D8P7M7.1/222-294       YEWRVFVDE........PDSVLQ.SIKEVQYVL.HPT..F.LE..PLQVSR....DATKQ...FELVTSG.WGQFTI.LITIV..YRDGTREKASYYLD
A6GGI8.1/28-99         YNVRVYVDG........SDEELR.RVEAVTYEL.HPS..F.RN..PVHRQT....NRASQ...FELTLWV.WGMFDI.EVEFE..LVDGGRARTRYYL-
A0A7K1U6L2.1/22-93     WEWWIWIEA........DKEDLD.IVDHVIYTL.HPT..F.YE..PVQTVK....DREEK...FKLLTEG.WGTFTI.HAKIV..LQDSTEIPLKHKL-
A0A2P8HUV5.1/16-89     YDLLIYVIP........HNEASLiQVKSVEYFL.GPF..W.GN..QVFKTK....NRSKG...FAVKTSA.YGEFLC.TAKIT..FTDNQEMFVHRYID
A0A1H4GLD9.1/119-192   YDLLIYVIP........HNNSTLiQVKSVEYFL.GPH..W.NN..QVFKTR....DRSKG...FAIKTSA.FGEFLC.TTKII..FTDGQEITINRYID
H0I105.1/47-122        FEWTAYVVA........DDSELR.NIKCVVYTL.HPT..F.PD..PVQRICd.tdNPRYP...FGLTVSG.WGSFNL.RTKIE..FKNGSSKEVVHRVD
A0A5S3PSQ9.1/23-95     YGWAIWIEP........NSNELS.EIAHVEYLL.HPT..F.KN..RLRTVE....DEQTG...FRLESKG.WGEFMI.EIIIY..KKNEEQLKLSHWLT
A0A0D1MS06.1/17-88     WRWHAWIES........GNTELD.KVKEVVWIL.HPS..F.RQ..PRVVSK....DRADK...FRLSTAG.WGTFVL.RAEVM..LSDAKKVLLKHNV-
A0A1Q4Y3I8.1/299-371   -HVRVFLDG........TATDLG.QVTKVVYHL.HPT..F.PR..PERQIA....DRSTG...FALELKA.WGQFTI.TADIF.tADSLIPTRLERYIS
A0A429Z2K6.1/33-104    YKVHIYLDG........-NDVLF.-VNSATYHL.HQT..F.DQ..PVRTISr..sIRNPN...CSLAIWT.WGIFTV.KVIVE..DKSGQKYEFVHPL-
A0A1H5J6B6.1/44-116    YKVYLFIEG........-K-DLP.FIKKVKYTL.HKT..F.RN..PVKTIEr..kSDNTN...CSLVIWT.WGLFNI.KVELE..DINGEIIHMNHYLN
A0A1G9RB69.1/23-94     FEWSIWIEN........-GELDVsEIDYVEYLL.HRT..F.KN..RLRKVT....DVSTG...FKLNSKG.WGEFRI.EISII..KKNRETIQMAHWL-
A0A238VT50.1/39-112    YKVKIYIDG........---LDLpYIKQVTYKL.HST..FgKN..RVNIIKr..tPSNLK...CGLTIWT.WGIFTV.NAEIE..DLKGRIIQLEHRLT
A0A401FTY8.1/469-541   YAFHAVIDA........PREILN.QINSVTYYL.HPS..Y.PN..PVRIVT....DMSTR...FKLKELA.WASSTL.KAEVR.lRNQEEPVRLSRHI-
B3PF04.1/159-232       YRVRVWLES........IEHRSLsDIESVTYHV.WDD..F.NQ..SVISTA....DASSN...FDLWLSI.YGEFPV.LALVK..TKEGQTYELQRYID
A0A4V3D7P7.1/160-234   YRVRVWLESf......aEQNMLK.DVASVTYQV.WED..F.PT..SSLSTS....DRASN...FDLWLNI.YGEFPV.LAMVK..MKDGNTIELQRYLD
G7WKS8.1/261-330       FRIKVLVTG........PDLY--.RIRSVHYQL.HPT..F.SP..SEQTMT....NPRDN...FELELWT.WGAFNM.PITVT..MTDGRAYRYDYRF-
K9Y025.1/78-143        WDWTVYIDE........DSSTIS.KIDCVEYTL.HPT..F.SN..RFQRVC...nSPTNN...FALSSNG.WGEFNI.RANAS.kFRDEQ---------
A0A4Q7P1F6.1/28-96     YQIFLQIESs......sFDPGLD.QVTYVEYKL.HKT..F.KN..RTRIAK....SKHNN...FEIEIKA.WGTFVV.QCTVG..QKDAEPFV------
A0A5C6A0B4.1/207-286   YDILIYLFRhrp.dnagSPFGLD.DVTKAEFLL.GPS..W.KN..RVFACD....NDGGY...IGIKVSA.FGTFLC.LCRVT..FANGETAILDRYID
H1YBZ3.1/303-372       YDVTLNVIN........AS-NNP.-IDSVQYFL.HYT..M.EH..PVLTMT....NPEQD...FYLSMAL.WGTFPI.KAKVF..FADGKVYDLYKNF-
A0A068NJT4.1/2203-2275 FRWRLFLDE........SPEFVQ.SVRSVRYIL.HDS..F.AL..SVRMTT....DASTD...FSLRSEG.WGTFEV.RMIIT..FRDGTQVAASHHLS
A0A0Q0UYQ3.1/302-371   FNINLSVTS........TDPNQP.LVGEVVFNL.HPS..F.MN..EVQKVK....VLDGV...AQYNIIG.WGAFTV.GVECD..---EGKTKLELDLA
A0A1M4ZUQ1.1/153-223   -RVNLFVKG.......dPTTESLkAGEYVEFFL.HDT..F.VP..DVFRTP....FIGNT...STLSVLA.FGGFTV.GAWIP..---SREVELELDLA
A0A077M6C1.1/122-201   -DLFVFLTGwrrsayglPDDLSD.-VSTAEFYL.GPN..FePS..GTTVTR....RHGST...LGFVTSA.WGPVIC.ACRVT..FTDGDQVILSRYLD
A0A1E3X4D0.1/186-267   YKLTYRVSVnpaaatvaEKPVMD.WIERVEYKF.SER..WfYN..PRMTSE....DRTKS...FEVDINV.WGRTNV.LVEIY.lKGVEKPIDRENMM-
A0A315ZBE7.1/96-170    YLFSIWVSS........DPDVME.EIESVHYVFnHGS..F.EI..KGRTGT....DLSDG...FKVSYQG.WGCLTLvEIIIR..YKNNAEEDLFFNMC
A0A257GHY9.1/585-650   -RINMFVEG........PALDGD.---EVLFYL.HDS..F.PK..NVWRER....FRSGS...ARLPVTA.WGGFTV.GIWIP..---RQRIELELDLA
A0A521G1G1.1/241-312   WEWTAYIDG........PASYLR.RISSVTYYL.HPS..F.NP..STQQGD....RTRPG...HPLTANG.WGVFVL.KAEVV..LDDGTRRIYQHQL-
B0UD07.1/274-346       --FTLVVES........RPGAGPpLAGPVRFHL.HPT..F.PR..EQVVVP....ARNGT...AELPIDFaYGAFTV.GAVVE..NDPPDENRLELDLS
A0A316E206.1/219-288   YNLTYKVFA........KDPSKVkLEGQVRFHL.HPT..F.KP..DVETVD....VVNGV...AKLKRVA.WGAFTI.GVEIL..---STGAKLELDL-
A0A0D2JRW3.1/32-107    -DIVIWLQQh......gKGPLSDgQIEKVEYQL.GNK..FfKE..PKVKIN....-AADA...FRLEVSA.YGPMLS.VARIY.iKNDPTSLILKRYIN
A0A285Z240.1/37-92     YKVRLFVDT........QNPE--.-VQNVTYKL.DPT..Y.YD..PVRESR....DADRN...FEVSLST.YGDYPV.TVEAQ..--------------
A0A4Q2URW5.1/225-294   FAVHLQVTA........PDSVQLpADAIVVFHL.HDS..F.TP..DEHRVM....FQQRA...ATLALYA.WGAFTV.GAEAP..----GGIHLELDLA
A0A561EHP3.1/131-204   FDVFVYLVT........SRTGSLdEVERAQFFL.GRR..W.GN..RVFDVL....NEGGR...IGFSTAA.YGSPLC.ACRVV..FKDGSDVVLSRFLD
A0A0N9I315.1/127-202   YQFEVIVIA........PDDVLR.RVVSVRYEL.EKA..W.PEhlRVRTVA....DRATR...FKLKELA.NGTSIV.TARID.lRGQDQPLLLNRFID
A0A1I0X758.1/580-649   -NFTFWLDV........PSFRKE.EIMEVRYNF.CQG..F.YD..RVRVSK....DPTSS...FSIGYLG.WGVCPTmKIDVV..LQTGDTIPINF---
A0A0J6NLX2.1/546-614   --IILTVEA........ERSAKIgLGDSAWFVL.HPT..F.SP..SALKVT....FRGNR...ARLRIQA.WGGFTV.GVWLS..---KAGIELECDLT
A0A5C6MHR3.1/13-65     ---------........------.--ASAVFYL.HPT..F.RN..PVREVA....LEDGI...ATLVVRA.WGSFTV.GVVLA..---GGRQQLELDLA
A0A3B0C0Z3.1/559-625   ---LMWIDV........PSFRKL.EIQEVHYYF.CPG..F.IN..RRRIST....EPTSS...FSIGYLG.YGYCPG.GYDINiiLKTGDTIHR-----
A0A1K1RCI2.1/368-437   -DVVLAVRS........TDPLNDpLKGKVTFYL.HPT..F.FE..PVIKVE....AVNSK...AQTEIRT.ADAFVV.GVECD..---DGRTVLELDLS
M7XDC6.1/273-345       YEVTLEVSSt......dPVQHPLfDGEIVIFAL.HPS..F.KP..EVRLVK....VVEGV...SRLKLIA.YGSFTV.GVFAD..---SAGTELELDLS
A0A5C6ZED2.1/575-641   -NYMLWVDV........PSFRKY.EIKQVNYKL.CSG..F.VD..RLRVSN....EPSSS...FSIGYLG.YGYCPIiDIDVI..LQTGDTIK------
A0A6M4MA94.1/108-181   YDIRVVVDS.......yYKGALD.RVKYVEYFL.HKS..Y.EE..PIQTRS....QKQNR...FLLKELA.NGEYVL.QAKVY.lRDRQEPFLLQRYI-
A0A5N1INE8.1/325-394   FNVHLKLES........INENNP.LSGVAKFYL.HDS..F.RE..PVYPAN....VIDGK...AALDLTT.FGAFTV.GVIAD..---GGETKLELDLK
A6G2X2.1/261-324       ----VEVRAl......hPTPGCAdQLDSVTYTL.HPT..F.AD..PVETLD....---GD...AALTLYT.WGSFDA.TVKVR..LDDGGSVTF-----
A0A0E9N359.1/323-394   FDIRIRVYA........DENSPT.LKGWVAFFV.HDSlgF.KN..DTVYAK...vNEKGI...AEIPLVA.YEAFTA.GALTE..----DGTELEIDLN
A0A1H8TUQ7.1/42-105    -SWKVFVIG........NPQFIK.SIKQIDYTL.DGT..YgQQ..HIVVIN...nGDNPF...FTMCNKG.WGEIYI.KIRIS..YNNG----------
A0A2S1QXU6.1/413-485   YEARGWIVQh......kPELYKGsLLEKVEWTA.GEY..F.-K..KIICLR....DDNPN...FSFSYHY.WGPMLI.QAKMF..FNDKSEAICYVY--
A0A0M8MFE3.1/402-474   FEARAWIASh......wEQKQDE.QLVKVEWSA.GPK..F.KK..KQIANF....DTNPN...FCIAYQY.YGPMVI.EAKMT..FADKYTATAFVY--
A0A370KZ76.1/390-455   -EFDLVVKG........SGKRRL.-RESVRFHY.HPT..F.DP..RSEVVE...pSAQGE...VRTTLRA.VGAFTV.GAITE..-----NTRLELDL-
A0A5C4XR65.1/170-235   --VSITVRA........TKSAT-.LTGIVDFFL.HDS..F.RP..NHYRIP....VAKGE...AKLVVRA.WGGFTV.GALAG..---EDRVPLELDL-
A0A255Z1E2.1/436-501   -RIRLTIAG........PARDGE.---LARFYV.HDS..F.VP..PELEGS....FLKGR...ASVEVTA.WGGFTV.GGWIP..---SAKLELELDLA
A0A4Y8SFE3.1/280-353   YNVSIWVES........TDETRP.LDTDVMFYL.HDS..F.RP..AVYTIKp.keFRNDK..aMDAGILS.YGAFTV.GVVTD..---NGETLLELDLA
A0A085EF71.1/305-378   YKVKLQIISt......dQKNNPLkNGEILLFAL.HNT..FgDP..PFQLVK....VEKQV...AELNFYS.SGSFTV.GAFAD..---NGATELELDLA
A0A142HGI1.1/301-372   YVIQAQVTG........TAARPL.QV-KVVLLL.HPT..F.SE..RAVEVLvdqrPAGGR...ATYSFAA.RGSFTL.VAMAD..---DGDTLLGYNL-
A0A0A0JR60.1/229-288   ---------........-----PmQVRAASFFL.GRA..W.GN..RVIPGL...pGSDGR...LGIVTQA.YGPFLA.LCEVE..FTDGSRILLDHYC-
A0A286IN77.1/269-336   FELLIEVTA.......fEPDSNF.-KTDIIVFL.DRT..F.PT..NTLYLK....PTGRT...VSVKVIA.YEAFTI.GALVN..----NEVELELDL-
A0A679HQF9.1/220-285   --ISLRVIS........MDPLRP.LTGTVQFYI.HQS..F.GK..YDPLVP....VIEGK...ALLNLTS.WGAFTV.GAVCD..----DGTKLELDL-
A0A7V7FQ23.1/2-44      ---------........------.--VKVEYVF.KER..WfRP..PVRTAI....NPANG...FEYSIRV.WGVTEV.KAVVH..--------------
A0A2Z3MZD8.1/209-282   YNVELRVES........TDPQKP.LNAPVIFYI.HDS..F.TP..SVYTVKp.eeFENGV..aVDNEILS.YGAFTA.GVMAD..---NGDTLLELDLS
A0A517XQ78.1/167-224   ---------........-----P.-AAEAILYL.HDT..F.RA..SERRLA....VGSGV...ATETIVA.YGGFTL.GVEVK..DGQTPPTRLELDLA
//