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0  structures 90  species 0  interactions 166  sequences 2  architectures

Family: SCGB3A (PF20490)

Summary: Secretoglobin 3A

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Secretoglobin 3A Provide feedback

This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins [1]. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma [2,3,4]. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation [5]. It is also involved in lung development [6] and has anti-fibrotic activity in lung [7].

Literature references

  1. Reynolds SD, Reynolds PR, Pryhuber GS, Finder JD, Stripp BR;, Am J Respir Crit Care Med. 2002;166:1498-1509.: Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. PUBMED:12406855 EPMC:12406855

  2. Inoue K, Wang X, Saito J, Tanino Y, Ishida T, Iwaki D, Fujita T, Kimura S, Munakata M;, Allergol Int. 2008;57:57-64.: Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma. PUBMED:18089940 EPMC:18089940

  3. Niimi T, Munakata M, Keck-Waggoner CL, Popescu NC, Levitt RC, Hisada M, Kimura S;, Am J Hum Genet. 2002;70:718-725.: A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. PUBMED:11813133 EPMC:11813133

  4. Chiba Y, Kurotani R, Kusakabe T, Miura T, Link BW, Misawa M, Kimura S;, Am J Respir Crit Care Med. 2006;173:958-964.: Uteroglobin-related protein 1 expression suppresses allergic airway inflammation in mice. PUBMED:16456148 EPMC:16456148

  5. Wang X, Tanino Y, Sato S, Nikaido T, Misa K, Fukuhara N, Fukuhara A, Saito J, Yokouchi H, Ishida T, Fujita T, Munakata M;, Inflammation. 2015;38:828-834.: Secretoglobin 3A2 attenuates lipopolysaccharide-induced inflammation through inhibition of ERK and JNK pathways in bronchial epithelial cells. PUBMED:25117566 EPMC:25117566

  6. Kurotani R, Tomita T, Yang Q, Carlson BA, Chen C, Kimura S;, Am J Respir Crit Care Med. 2008;178:389-398.: Role of secretoglobin 3A2 in lung development. PUBMED:18535256 EPMC:18535256

  7. Cai Y, Kimura S;, PLoS One. 2015;10:e0142497.: Secretoglobin 3A2 Exhibits Anti-Fibrotic Activity in Bleomycin-Induced Pulmonary Fibrosis Model Mice. PUBMED:26559674 EPMC:26559674

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Uteroglobin (CL0370), which has the following description:

Members of this superfamily are disulfide-linked dimers of two identical chains, with 4 helices in each. They constitute important new cat, rat and rabbit allergens that are contributing to asthma world-wide.

The clan contains the following 3 members:

Feld-I_B SCGB3A Uteroglobin


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

Representative proteomes UniProt
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

This family is new in this Pfam release.

Seed source: Manual
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Chuguransky S
Number in seed: 31
Number in full: 166
Average length of the domain: 72.3 aa
Average identity of full alignment: 56 %
Average coverage of the sequence by the domain: 64.92 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 42.7 42.7
Trusted cut-off 60.0 60.0
Noise cut-off 25.3 19.7
Model length: 68
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
E9PU36 View 3D Structure Click here
Q71MM7 View 3D Structure Click here
Q920D7 View 3D Structure Click here
Q920H1 View 3D Structure Click here
Q96PL1 View 3D Structure Click here
Q96QR1 View 3D Structure Click here