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Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

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Browse Pfam families

New Top twenty Numbers A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
ID Accession Type Number of sequences Average length Average %id Average coverage Has 3D Change status Description
Seed Full
K-box PF01486 Family 166 8508 90.5 30 40.58 Changed K-box region
K-cyclin_vir_C PF09080 Domain 2 6 102.5 49 39.91 Changed K cyclin, C terminal
K1 PF02960 Family 1 2 122.5 88 43.52 Changed K1 glycoprotein
K1377 PF15352 Family 18 549 494 25 77.79 Changed Susceptibility to monomelic amyotrophy
KA1 PF02149 Domain 81 6617 44.7 49 5.83 Changed Kinase associated domain 1
KAAG1 PF15354 Family 2 20 81.8 61 85.79 Changed Kidney-associated antigen 1
KaiA PF07688 Domain 23 146 117.8 54 47.76 Changed KaiA C-terminal domain
KaiB PF07689 Domain 12 1007 81.7 40 48.79 Changed KaiB domain
KAP PF05804 Family 3 1622 471.5 41 83.02 Changed Kinesin-associated protein (KAP)
KapB PF08810 Domain 19 310 111.7 46 87.73 Changed Kinase associated protein B
KAP_NTPase PF07693 Domain 17 3862 360.4 20 37.25 Changed KAP family P-loop domain
KAR PF15222 Family 2 3 98.7 59 85.8 Changed Kidney androgen-regulated
KAR9 PF08580 Family 17 709 582.3 28 63.9 Changed Yeast cortical protein KAR9
KASH PF10541 Domain 32 2191 57.2 58 1.25 Changed Nuclear envelope localisation domain
KASH_CCD PF14662 Coiled-coil 9 570 173.8 41 19.22 Changed Coiled-coil region of CCDC155 or KASH
KAsynt_C_assoc PF16197 Family 81 23783 117.8 26 6.01 Changed Ketoacyl-synthetase C-terminal extension
Katanin_con80 PF13925 Domain 67 2185 144.6 33 23.01 Changed con80 domain of Katanin
Kazal_1 PF00050 Domain 25 8033 52.7 28 16.66 Changed Kazal-type serine protease inhibitor domain
Kazal_2 PF07648 Domain 40 27745 47.3 30 13.52 Changed Kazal-type serine protease inhibitor domain
Kazal_3 PF18434 Domain 22 515 49.5 48 6.06 Changed Kazal-type serine protease inhibitor domain
KbaA PF14089 Family 23 444 175.5 38 84.09 Changed KinB-signalling pathway activation in sporulation
KBP_C PF12309 Family 28 800 301.5 33 55.92 Changed KIF-1 binding protein C terminal
KBTB_W-LIR PF20165 Motif 5 136 12 88 1.8 New KBTB, W-type LIR motif
KCH PF16944 Family 86 797 242 39 41.96 Changed Fungal potassium channel
KcnmB2_inactiv PF09303 Domain 5 362 29.1 67 12.03 Changed KCNMB2, ball and chain domain
KCNQ2_u3 PF16642 Disordered 10 767 94.5 59 11.52 Changed Unstructured region on Potassium channel subunit alpha KvLQT2
KCNQC3-Ank-G_bd PF11956 Family 10 1027 100 59 12.4 Changed Ankyrin-G binding motif of KCNQ2-3
KCNQ_channel PF03520 Family 12 3856 154.4 42 23.35 Changed KCNQ voltage-gated potassium channel
KCT2 PF17818 Family 5 668 181.6 28 51.39 Changed Keratinocyte-associated gene product
KCTD11_21_C PF19329 Family 3 354 145.9 52 53.05 Changed BTB/POZ domain-containing protein KCTD11/21 C-terminus
KCTD18_C PF19321 Family 12 209 268.5 63 72.02 Changed BTB/POZ domain-containing protein KCTD18 C-terminus
KCTD4_C PF19323 Family 3 231 121.7 83 46.79 Changed BTB/POZ domain-containing protein KCTD4 C-terminus
KdgM PF06178 Family 4 255 205.2 24 92.05 Changed Oligogalacturonate-specific porin protein (KdgM)
KDGP_aldolase PF07071 Domain 9 331 210.8 54 88.41 Changed KDGP aldolase
KdgT PF03812 Family 58 741 295.3 41 92.12 Changed 2-keto-3-deoxygluconate permease
Kdo PF06293 Family 10 4428 159.4 18 47.22 Changed Lipopolysaccharide kinase (Kdo/WaaP) family
Kdo_hydroxy PF11004 Family 17 258 273 47 92.87 Changed 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase
KdpA PF03814 Family 204 3274 532 48 97.46 Changed Potassium-transporting ATPase A subunit
KdpC PF02669 Family 284 3385 174.1 41 91.4 Changed K+-transporting ATPase, c chain
KdpD PF02702 Family 222 3495 206.6 54 28.19 Changed Osmosensitive K+ channel His kinase sensor domain
KduI PF04962 Domain 69 4117 251.2 28 90.45 Changed KduI/IolB family
KDZ PF18758 Family 249 5815 176.8 21 28.77 Changed Kyakuja-Dileera-Zisupton transposase
Kei1 PF08552 Family 69 733 169.8 32 56.41 Changed Inositolphosphorylceramide synthase subunit Kei1
KELAA PF19311 Motif 33 1624 31.4 47 3.62 Changed KELAA motif
Kelch_1 PF01344 Repeat 147 114744 45.8 27 21.31 Changed Kelch motif
Kelch_2 PF07646 Repeat 41 3885 49.6 24 9.22 Changed Kelch motif
Kelch_3 PF13415 Repeat 57 13912 52.9 27 8.67 Changed Galactose oxidase, central domain
Kelch_4 PF13418 Repeat 51 22327 50.9 23 9.71 Changed Galactose oxidase, central domain
Kelch_5 PF13854 Repeat 57 7851 42.4 27 6.1 Changed Kelch motif
Kelch_6 PF13964 Repeat 127 9150 52.5 22 8.98 Changed Kelch motif
KELK PF15796 Coiled-coil 28 1865 79.5 61 4.82 Changed KELK-motif containing domain of MRCK Ser/Thr protein kinase
Keratin PF02422 Family 22 2421 88.4 52 80.27 Changed Keratin
Keratin_2_head PF16208 Family 40 5052 102.7 35 21.63 Changed Keratin type II head
Keratin_2_tail PF16210 Disordered 7 98 120.2 72 20.77 Changed Keratin type II cytoskeletal 1 tail
Keratin_assoc PF09775 Family 21 686 115.6 46 82.84 Changed Keratinocyte-associated protein 2
Keratin_B2 PF01500 Family 8 622 85.7 39 83.04 Changed Keratin, high sulfur B2 protein
Keratin_B2_2 PF13885 Family 55 8335 47.1 39 76.16 Changed Keratin, high sulfur B2 protein
Keratin_matx PF04579 Family 11 218 94.6 72 95.09 Changed Keratin, high-sulphur matrix protein
ketoacyl-synt PF00109 Domain 77 55189 234.3 26 19.13 Changed Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_2 PF13723 Domain 28 985 202.7 23 74.03 Changed Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C PF02801 Domain 79 52050 115.3 34 8.99 Changed Beta-ketoacyl synthase, C-terminal domain
KfrA_N PF11740 Family 80 994 120.4 21 38.65 Changed Plasmid replication region DNA-binding N-term
KfrB PF18790 Domain 19 44 60.4 42 44.74 Changed KfrB protein
KGG PF10685 Family 70 3130 20.9 43 42.63 Changed Stress-induced bacterial acidophilic repeat motif
KGK PF08872 Domain 17 227 105.9 24 80.46 Changed KGK domain
KHA PF11834 Family 94 2389 65.8 35 10.42 Changed KHA, dimerisation domain of potassium ion channel
KH_1 PF00013 Domain 783 109086 65.1 23 22.52 Changed KH domain
KH_10 PF17905 Domain 3 37 94.1 42 11.73 Changed GLD-3 KH domain 5
KH_2 PF07650 Domain 127 19271 76.4 26 27.42 Changed KH domain
KH_4 PF13083 Domain 116 5832 72.7 28 54.27 Changed KH domain
KH_5 PF13184 Domain 29 8112 68.8 50 16.16 Changed NusA-like KH domain
KH_6 PF15985 Domain 242 2965 48.1 33 16.63 Changed KH domain
KH_7 PF17214 Domain 48 295 67.3 41 10.62 Changed KH domain
KH_8 PF17903 Domain 7 2265 79.2 53 23.31 Changed Krr1 KH1 domain
KH_9 PF17904 Domain 5 2467 84.3 60 14.36 Changed FMRP KH0 domain
KH_dom-like PF14714 Domain 533 8585 80.5 38 16.98 Changed KH-domain-like of EngA bacterial GTPase enzymes, C-terminal
KI67R PF08065 Repeat 83 1944 104 43 37.03 Changed KI67R (NUC007) repeat
Kiaa1109_N PF20413 Family 80 2061 828.6 27 25.08 New Kiaa1109 N-terminal region
KIAA1328 PF15369 Family 9 524 203.5 38 51.84 Changed Uncharacterised protein KIAA1328
KicB PF03882 Domain 11 248 113.5 63 26.26 Changed MukF winged-helix domain
KID PF02524 Repeat 2 50 11 81 17.4 Changed KID repeat
KIF1B PF12423 Family 63 4930 46.9 42 2.84 Changed Kinesin protein 1B
KilA-N PF04383 Domain 137 3392 100.2 22 28.34 Changed KilA-N domain
Kin17_mid PF10357 Family 109 1840 122.9 47 32.54 Changed Domain of Kin17 curved DNA-binding protein
Kinase-like PF14531 Family 5 139 231.7 19 44.07 Changed Kinase-like
Kinase-PolyVal PF18762 Family 24 108 140.3 30 63.33 Changed Serine/Threonine/Tyrosine Kinase found in polyvalent proteins
Kinase-PPPase PF03618 Family 298 3961 252.3 35 89.99 Changed Kinase/pyrophosphorylase
KinB_sensor PF16767 Family 7 56 120.3 28 20.52 Changed Sensor domain of alginate biosynthesis sensor protein KinB
KIND PF16474 Domain 18 1896 146.7 33 19.22 Changed Kinase non-catalytic C-lobe domain
Kindlin_2_N PF18124 Domain 3 1780 82.4 63 12.65 Changed Kindlin-2 N-terminal domain
Kinesin PF00225 Domain 69 61809 298.5 33 30.8 Changed Kinesin motor domain
Kinesin_assoc PF16183 Family 11 7020 114.9 42 8.57 Changed Kinesin-associated
Kinetochor_Ybp2 PF08568 Repeat 28 1889 401.5 15 79.89 Changed Uncharacterised protein family, YAP/Alf4/glomulin
Kinin PF08260 Family 3 0 0 0 0 Changed Insect kinin peptide
Kinocilin PF15033 Family 4 261 86.8 50 84.98 Changed Kinocilin protein
KIP1 PF07765 Family 33 2556 69.3 53 7.28 Changed KIP1-like protein
Kisspeptin PF15152 Domain 8 104 73.2 57 42.47 Changed Kisspeptin
KIX PF02172 Domain 5 1912 80.3 80 3.68 Changed KIX domain
KIX_2 PF16987 Domain 59 1939 77.8 35 10.72 Changed KIX domain
KKLCAg1 PF15204 Family 7 79 84.3 63 70.87 Changed Kita-kyushu lung cancer antigen 1
kleA_kleC PF17383 Family 4 21 74.8 44 80.94 Changed Uncharacterized KorC regulated protein A
KleE PF17394 Family 4 33 104 39 96.57 Changed Uncharacterized KleE stable inheritance protein
KLRAQ PF10205 Coiled-coil 8 829 97.3 54 14.06 Changed Predicted coiled-coil domain-containing protein
KMP11 PF03037 Family 2 22 88.2 84 74.07 Changed Kinetoplastid membrane protein 11
KMPT-N PF20294 Family 25 47 64.6 23 17.77 New KTSC and Metallopeptidase N-terminal fusion domain
KN17_SH3 PF18131 Domain 7 978 52.7 51 12.33 Changed KN17 SH3-like C-terminal domain
Knl1_RWD_C PF18210 Domain 239 968 168.5 20 11.59 Changed Knl1 RWD C-terminal domain
KNOX1 PF03790 Family 37 2387 42.1 46 12.69 Changed KNOX1 domain
KNOX2 PF03791 Family 32 2452 49 45 14.97 Changed KNOX2 domain
KNTase_C PF07827 Domain 6 60 128.6 35 49.29 Changed KNTase C-terminal domain
KN_motif PF12075 Motif 11 1414 39.5 63 3.76 Changed KN motif
KORA PF16509 Domain 6 93 81.4 30 75.02 Changed TrfB plasmid transcriptional repressor
KorB PF08535 Domain 6 248 86.4 24 26.36 Changed KorB domain
KorB_C PF06613 Domain 6 57 58.3 45 16.41 Changed KorB C-terminal beta-barrel domain
KOW PF00467 Family 167 19962 34.2 31 15.07 Changed KOW motif
Kp4 PF09044 Domain 14 359 117.9 35 77.08 Changed Kp4
KPBB_C PF19292 Domain 57 3147 183.1 37 16.63 Changed Phosphorylase b kinase C-terminal domain
KPP10_Orf10 PF11681 Family 7 248 133.4 22 89.22 Changed Bacteriophage KPP10, Structural protein ORF10
KptA_kDCL PF18176 Domain 4 6 175.3 19 11.29 Changed KptA in kinetoplastid DICER domain
KR PF08659 Family 47 22390 173.8 33 8.75 Changed KR domain
KRAB PF01352 Family 427 39716 41.1 52 7.92 Changed KRAB box
KRAP_IP3R_bind PF14722 Family 18 1108 140 45 15.65 Changed Ki-ras-induced actin-interacting protein-IP3R-interacting domain
KRBA1 PF15287 Repeat 22 1497 42.8 34 21.32 Changed KRBA1 family repeat
KRE1 PF17056 Family 40 211 65.5 33 33.61 Changed Killer toxin-resistance protein 1
Kre28 PF17097 Family 5 29 330.2 24 94.3 Changed Spindle pole body component
Kre9_KNH PF10342 Domain 63 3863 92.4 20 35.68 Changed Kre9/KNH-like N-terminal Ig-like domain
Kre9_KNH1_C PF05390 Domain 34 396 92.4 40 34.18 Changed Yeast cell wall synthesis protein KRE9/KNH1 C-terminal
Kri1 PF05178 Family 139 1618 106.2 33 15.55 Changed KRI1-like family
Kri1_C PF12936 Family 118 1647 89.7 36 13.14 Changed KRI1-like family C-terminal
Kringle PF00051 Domain 23 13699 78 40 21.5 Changed Kringle domain
KRTAP PF11759 Family 16 506 57.2 52 74.86 Changed Keratin-associated matrix
KRTAP7 PF15034 Family 3 71 83.7 83 94.05 Changed KRTAP type 7 family
KRTDAP PF15200 Family 6 158 68 63 57.04 Changed Keratinocyte differentiation-associated
KshA_C PF19298 Domain 116 1542 201.8 26 54.95 Changed 3-Ketosteroid 9alpha-hydroxylase C-terminal domain
KSHV_K1 PF11049 Domain 1 2 71 90 25.22 Changed Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus
KSHV_K8 PF07188 Family 1 3 210.7 45 78.02 Changed Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein
KTI12 PF08433 Domain 18 2139 256.4 25 75.22 Changed Chromatin associated protein KTI12
KTSC PF13619 Domain 102 1363 57.5 28 49.27 Changed KTSC domain
Ku PF02735 Domain 210 7775 192.2 22 40.03 Changed Ku70/Ku80 beta-barrel domain
Kunitz_BPTI PF00014 Domain 99 23880 53.1 36 14.35 Changed Kunitz/Bovine pancreatic trypsin inhibitor domain
Kunitz_legume PF00197 Domain 97 1830 159.4 30 78.78 Changed Trypsin and protease inhibitor
Ku_C PF03730 Family 75 2457 90.1 25 13.85 Changed Ku70/Ku80 C-terminal arm
Ku_N PF03731 Domain 12 3475 206.4 20 31.12 Changed Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind PF08785 Domain 95 1592 113.6 28 15.96 Changed Ku C terminal domain like
Kv2channel PF03521 Family 6 740 177.7 31 28.79 Changed Kv2 voltage-gated K+ channel
KxDL PF10241 Domain 71 1316 83.7 34 44.7 Changed Uncharacterized conserved protein
KxYKxGKxW_sig PF19258 Motif 274 525 40.1 29 3.53 Changed KxYKxGKxW signal peptide
K_channel_TID PF07941 Family 5 190 74.6 65 11.46 Changed Potassium channel Kv1.4 tandem inactivation domain
K_trans PF02705 Family 47 10379 453.5 36 75.53 Changed K+ potassium transporter
New Top twenty Numbers A B C D E F G H I J K L M N O P Q R S T U V W X Y Z