!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at legacy.pfam.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: A0A5K4E9D9_SCHMA (A0A5K4E9D9)

Summary

This is the summary of UniProt entry A0A5K4E9D9_SCHMA (A0A5K4E9D9).

Description: Putative DNA mismatch repair protein MLH1 {ECO:0000313|WBParaSite:Smp_009550.2}
Source organism: Schistosoma mansoni (Blood fluke) (NCBI taxonomy ID 6183)
Length: 679 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 18 29
Pfam DNA_mis_repair 102 170
disorder n/a 189 211
disorder n/a 214 217
disorder n/a 222 227
disorder n/a 233 238
disorder n/a 241 242
disorder n/a 245 277
disorder n/a 280 288
disorder n/a 291 296
disorder n/a 298 334
Pfam Mlh1_C 393 679
low_complexity n/a 591 607

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A0A5K4E9D9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDAIRAVIGS SIEQNLISFT SSQCSSSEST RLAIERYGLR YEGLLTAPNQ
50
51
VSSGCSPSLK LNLFINNRLV SCTPIKRIVE CAYSSVISRG LSSNSTDHQA
100
101
VLTNKKFKIS TNSNIMYKSS TFNSLYVYLN IQLPVHTLDV NVHPTKAEVN
150
151
FLHEDEIVNG LQDAVEQALL SSAQIQTFVR NCLPTPITFK NPKELNTHND
200
201
RSTDRPNEKV RIDLREQQLE RFLSPQSNYM NNNMACSKLE RLHNNSLKKS
250
251
IGEMSPDIEV DSDEADEILK SNLLQENSSW NNSELDRSKI KATTEQSHLF
300
301
YDQQEKDFDE NELTTTAQNH SQSYTNSNAT IDNNDTTVSL TSKPIIRTDT
350
351
SLSSLQNTTT INDLLSKSNT LLAYSNNDMI ESISSKPRHR TVYLMSILAL
400
401
KRNLECDLDQ SIKNTLRSCK FIGFIDETRC LAQHHTELLL IRLKPLSQAL
450
451
FYQLLLTNFG NHGEIILREP APLADLLSIG HEYLRKSSRY LSNLSSIEFI
500
501
KEATATLVKH ASMLWDYFSI KITTDSNGNQ VLTGIPLIIA DYIPELNQLP
550
551
IYVTKLATQV SWSVESICFE NICCITANFY AVSSSLFNDC SSSPISSSTS
600
601
IIDDKSDKEN TVSSSSLSPR EWMIQHILWP ILCSSLLPSR RYPNFDLDHN
650
651
ENDNKSFSLQ SCFIRLTSLT DLYKVFERC                       
679
 

Show the unformatted sequence.

Checksums:
CRC64:DB7199CF4DD26485
MD5:2d38e101810d0b7b440a22f42493ec69

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;