!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at legacy.pfam.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HOA2_MYCSK (A1UQA1)

Summary

This is the summary of UniProt entry HOA2_MYCSK (A1UQA1).

Description: 4-hydroxy-2-oxovalerate aldolase 2 {ECO:0000255|HAMAP-Rule:MF_01656}
Source organism: Mycobacterium sp. (strain KMS) (NCBI taxonomy ID 189918)
Length: 349 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 5
Pfam HMGL-like 15 274
low_complexity n/a 92 97
Pfam DmpG_comm 283 345

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A1UQA1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTETVSRPHA TEGAALYIQD VTLRDGMHAM RHRISPEKVA AIAGALDTAG
50
51
VDAIEVTHGD GLAGHSLTYG PGSNTDWEWI EAAADVVHRA KLTTLLLPGV
100
101
GTVRELEHAY KLGVTSVRVA THCTEADVSA QHIGTARELG MDVSGFLMMS
150
151
HLAEPSHLAA QAKLMESYGA HCVYVTDSGG RLTMGSVRDR VRAYRDVLDA
200
201
GTQIGIHAHQ NLSLSVANTV VAVEEGVTRV DASLAGHGAG AGNCPIEPFI
250
251
AVADLHGWKH NCDLFGLQDA ADDIVRPLQD RPVQVDRETL TLGYAGVYSS
300
301
FLRHAEAAAK QYGLDTRAIL LAVGERGLVG GQEDLIPDIA LDLQQNLRR 
349
 

Show the unformatted sequence.

Checksums:
CRC64:45E766A870730D8C
MD5:6394fb3eda760f1f0dd7a899a07c85f0

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;