!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at legacy.pfam.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HOA1_NOVAD (A4XF35)

Summary

This is the summary of UniProt entry HOA1_NOVAD (A4XF35).

Description: 4-hydroxy-2-oxovalerate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_01656}
Source organism: Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) (NCBI taxonomy ID 279238)
Length: 346 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam HMGL-like 12 271
Pfam DmpG_comm 280 342

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A4XF35. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTSNFNVEAG DKLYIQDVTL RDGMHAVRHM YGIDHVRSIA SALDKAGVDA
50
51
IEVAHGDGLS GASFNYGFGA HTDWEWLEAV ADVLEKSVLT TLILPGVGTV
100
101
EELRRAYDIG VRSVRVATHC TEADVSKQHI GIARDLGMDV SGFLMMSHMI
150
151
EPEALAQQAS LMESYGAQCV YVTDSGGALD MDGVKARLEA YDRVLKPETQ
200
201
RGIHAHHNLA LGVANSIVAA QCGAVRIDAS LTGMGAGAGN APLEVFIAAA
250
251
DRKGWNHGCD VMMLMDAAED LVRPLQDRPV RVDRETLALG YAGVYSSFLR
300
301
HAEKAAETYG LDTRTILVEL GRRKMVGGQE DMIVDVALDM LKEQQA    
346
 

Show the unformatted sequence.

Checksums:
CRC64:2724E8329BA57375
MD5:be76f52897a29af5e66961c5d9c330b2

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;