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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HOA1_SPHWW (A5V6T8)

Summary

This is the summary of UniProt entry HOA1_SPHWW (A5V6T8).

Description: 4-hydroxy-2-oxovalerate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_01656}
Source organism: Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) (NCBI taxonomy ID 392499)
Length: 349 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HMGL-like 9 268
low_complexity n/a 80 91
Pfam DmpG_comm 277 339
disorder n/a 348 349

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A5V6T8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSFDVGKDKL YIQDVTLRDG MHAIRHMYGI DHVRAIARAL DEAGVDAIEV
50
51
AHGDGLNGAS FNYGFGAHTD WEWLEAVADV LTRSVLTTLL VPGIGTVEEL
100
101
RRAHALGVRS VRVATHCTEA DVSKQHIGIA RDLGMDVSGF LMMSHMIEPE
150
151
ALAQQALLME SYGAQCVYVT DSGGALDMDG VRARFQAYDR VLRPETQRGM
200
201
HAHHNLSLGV ANSIVAAQQG AVRIDASLAG MGAGAGNAPL EVFVAAVDRK
250
251
GWNHGCDVNA LMDAAEDLVR PLQDRPVRVD RETLALGYAG VYSSFLRHAE
300
301
KAAADYGLDA REILIELGHR KMVGGQEDMI VDVALDIKRR AEGKRAVAP 
349
 

Show the unformatted sequence.

Checksums:
CRC64:041901C2E20A307F
MD5:e808ac6816d8a82429529e13947009da

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;