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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAST2_HUMAN (A6NHX0)

Summary

This is the summary of UniProt entry CAST2_HUMAN (A6NHX0).

Description: Cytosolic arginine sensor for mTORC1 subunit 2 {ECO:0000312|HGNC:HGNC:37073}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 329 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Castor1_N 9 69
Pfam ACT_7 71 141
low_complexity n/a 83 91
Pfam ACT_7 259 323

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession A6NHX0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELHILEHRL QVASVAKESI PLFTYGLIKL AFLSSKTRCK FFSLTETPED
50
51
YTIIVDEEGF LELPSSEHLS VADATWLALN VVSGGGSFSS SQPIGVTKIA
100
101
KSVIAPLADQ NISVFMLSTY QTDFILVRER DLPFVTHTLS SEFTILRVVN
150
151
GETVAAENLG ITNGFVKPKL VQRPVIHPLS SPSNRFCVTS LDPDTLPAVA
200
201
TLLMDVMFYS NGVKDPMATG DDCGHIRFFS FSLIEGYISL VMDVQTQQRF
250
251
PSNLLFTSAS GELWKMVRIG GQPLGFDECG IVAQISEPLA AADIPAYYIS
300
301
TFKFDHALVP EENINGVISA LKVSQAEKH                       
329
 

Show the unformatted sequence.

Checksums:
CRC64:BC86CEFC0FBC21B2
MD5:2e07545a787f6c2cfff6e2ae92fc59bb

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;