!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at legacy.pfam.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HOA1_MYCMM (B2HGH1)

Summary

This is the summary of UniProt entry HOA1_MYCMM (B2HGH1).

Description: 4-hydroxy-2-oxovalerate aldolase 1 {ECO:0000255|HAMAP-Rule:MF_01656}
Source organism: Mycobacterium marinum (strain ATCC BAA-535 / M) (NCBI taxonomy ID 216594)
Length: 344 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam HMGL-like 4 263
low_complexity n/a 71 82
Pfam DmpG_comm 272 334
disorder n/a 343 344

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession B2HGH1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIRDLYISDV TLRDGMHAVR HQYSIAQAVA IARALDDAGV DSIEVAHGDG
50
51
LGGSSCCYGF GAHTDLQWIE AVAGAVDRAR VATLLLPGIG SVANLEDAHR
100
101
AGASVVRVGT HCTEADLAAR YLGAARDLGM DAVGFLMMSH LTTPKRLAEQ
150
151
AKLLEGYGAS CVYVVDSGGA LTGAAVAQRF DALRQNLDPA TELGIHAHHN
200
201
LSLGVANSVV AVEHGARRID ASLAGMGAGA GNAPLEVLIA VVNRLGWTHG
250
251
CELNALEDAA DDLVRPLQDR PVRIDRETLT LGYAGVYSSF LRHAEVTAGR
300
301
YGVDARSLLE EAGRRGLIGG QEDLLVDIAL DLVGPAEPLA HGAP      
344
 

Show the unformatted sequence.

Checksums:
CRC64:09BDCEF5106205B7
MD5:20a32a6ebe712d32ca52e6d91ac06ac7

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;