Summary

This is the summary of UniProt entry LARA_THETC (D9TQ02).

Description:

Lactate racemase {ECO:0000303|PubMed:24710389}

Source organism:

Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum) (NCBI taxonomy ID 580327)

Length:

426 amino acids

Reference Proteome:

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source	Domain	Start	End	Gathering threshold (bits)		Score (bits)		E-value
Source	Domain	Start	End	Sequence	Domain	Sequence	Domain	Sequence	Domain
Pfam	Lar_N	8	213	23.3	23.3	238.4	237.6	1.4e-67	2.5e-67
disorder	n/a	342	346	n/a	n/a	n/a	n/a	n/a	n/a

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession D9TQ02. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:

1

MANIEIPYGK SKLAFDLPDE RIQGILRSKA GSYKVNMSEE DIVKRALENP

50

51

IGTKRLQDLA EGKKNIVIIT SDHTRPVPSR ITLPLLLDEI RKKNKSANVK

100

101

ILIATGFHRG TTLQEMKAKF GEDLVENEQF VVHDSRNSEN MELIGTLPSG

150

151

GKLEINKLAV EADLLVAEGF IEPHFFAGFS GGRKSILPGI ASVQCILANH

200

201

CSEFIKNPYA RTGVLENNPI HRDMIYAAKK ANLAFILNVV IDSSHKIVNA

250

251

FAGHSEKAHL KGCEFVSEIA TVNAKPADIV ITSNGGYPLD QNIYQSVKGM

300

301

TAGEAACKDG GVIIIAAECA DGHGGEGFYR WFKESKDPQD VMNKILSRGR

350

351

DETLPDQWEA QILARILINH KVIMVTDSKN YEYVKDMFMT PAKDLGEALK

400

401

IAESIVNNDS KINVIPDGVS VIVREK

426

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Checksums:

CRC64:FBC204F4B8CC0212

MD5:80a56106b8b28a475f796d25629de8bb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family	UniProt residues	PDB ID	PDB chain ID	PDB residues	View
Lar_N	8 - 213	2YJG	A	8 - 213	Show 3D Structure View in InterPro
Lar_N	8 - 213	2YJG	B	8 - 213	Show 3D Structure View in InterPro

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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

	Very High (pLDDT > 90)
	Confident (90 > pLDDT > 70)
	Low (70 > pLDDT > 50)
	Very Low (pLDDT < 50)

Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;

Protein: LARA_THETC (D9TQ02)