Summary

This is the summary of UniProt entry RSME_AQUAE (O66552).

Description:

Ribosomal RNA small subunit methyltransferase E EC=2.1.1.193

Source organism:

Aquifex aeolicus (strain VF5) (NCBI taxonomy ID 224324)

Length:

229 amino acids

Reference Proteome:

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source	Domain	Start	End	Gathering threshold (bits)		Score (bits)		E-value
Source	Domain	Start	End	Sequence	Domain	Sequence	Domain	Sequence	Domain
Pfam	PUA_4	16	61	23.9	23.9	26.3	25.5	0.02	0.035
Pfam	Methyltrans_RNA	67	227	23.9	23.9	142.2	141.7	3.8e-38	5.1e-38

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O66552. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:

1

MHVFYSEERR GNLLILREGE VKHFRVRRIE KDEEFGVIHE GKIYVCKVRR

50

51

EDKREISCEI VEELETKLPP KDITLYQSVT VDLKTMDTIV RQATELGVLT

100

101

FVPIISERSF QKEEAILKKT EKWKRIVIEA MKQSRRPIPM EIKKPVRLSD

150

151

LIPESEENII LDNFYEGVKP KDVNLEAKTY SVVVGPEGGF SKRESQILRE

200

201

KGFKSVLLEP YTLRTETAVV SIVSILMNF

229

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Checksums:

CRC64:5E83FB8432B5B500

MD5:6955db91bc308928f7936f6f6bb9fcec

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family	UniProt residues	PDB ID	PDB chain ID	PDB residues	View
Methyltrans_RNA	67 - 227	2EGV	A	67 - 227	Show 3D Structure View in InterPro
		2EGV	B	67 - 227	Show 3D Structure View in InterPro
		2EGW	A	67 - 227	Show 3D Structure View in InterPro
		2EGW	B	67 - 227	Show 3D Structure View in InterPro
PUA_4	16 - 61	2EGV	A	16 - 61	Show 3D Structure View in InterPro
		2EGV	B	16 - 61	Show 3D Structure View in InterPro
		2EGW	A	16 - 61	Show 3D Structure View in InterPro
		2EGW	B	16 - 61	Show 3D Structure View in InterPro

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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

	Very High (pLDDT > 90)
	Confident (90 > pLDDT > 70)
	Low (70 > pLDDT > 50)
	Very Low (pLDDT < 50)

Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;

Protein: RSME_AQUAE (O66552)