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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPA_STAA8 (P02976)

Summary

This is the summary of UniProt entry SPA_STAA8 (P02976).

Description: Immunoglobulin G-binding protein A
Source organism: Staphylococcus aureus (strain NCTC 8325 / PS 47) (NCBI taxonomy ID 93061)
Length: 516 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 36
Pfam YSIRK_signal 2 26
disorder n/a 32 39
Pfam B 36 88
disorder n/a 41 52
disorder n/a 59 73
disorder n/a 75 102
Pfam B 97 149
disorder n/a 104 108
disorder n/a 111 113
disorder n/a 120 172
Pfam B 155 207
disorder n/a 177 192
disorder n/a 194 218
Pfam B 213 265
disorder n/a 220 221
disorder n/a 226 230
disorder n/a 236 493
Pfam B 271 323
Pfam Octapeptide 326 333
Pfam Octapeptide 334 341
Pfam Octapeptide 342 349
Pfam Octapeptide 350 357
Pfam Octapeptide 358 365
Pfam Octapeptide 366 373
Pfam Octapeptide 374 381
Pfam Octapeptide 382 389
Pfam Octapeptide 390 397
Pfam Octapeptide 398 405
Pfam Octapeptide 406 413
Pfam Octapeptide 414 421
Pfam LysM 423 466
Pfam Gram_pos_anchor 474 515
transmembrane n/a 491 510
low_complexity n/a 498 511

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P02976. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKKKNIYSIR KLGVGIASVT LGTLLISGGV TPAANAAQHD EAQQNAFYQV
50
51
LNMPNLNADQ RNGFIQSLKD DPSQSANVLG EAQKLNDSQA PKADAQQNNF
100
101
NKDQQSAFYE ILNMPNLNEA QRNGFIQSLK DDPSQSTNVL GEAKKLNESQ
150
151
APKADNNFNK EQQNAFYEIL NMPNLNEEQR NGFIQSLKDD PSQSANLLSE
200
201
AKKLNESQAP KADNKFNKEQ QNAFYEILHL PNLNEEQRNG FIQSLKDDPS
250
251
QSANLLAEAK KLNDAQAPKA DNKFNKEQQN AFYEILHLPN LTEEQRNGFI
300
301
QSLKDDPSVS KEILAEAKKL NDAQAPKEED NNKPGKEDNN KPGKEDNNKP
350
351
GKEDNNKPGK EDNNKPGKED GNKPGKEDNK KPGKEDGNKP GKEDNKKPGK
400
401
EDGNKPGKED GNKPGKEDGN GVHVVKPGDT VNDIAKANGT TADKIAADNK
450
451
LADKNMIKPG QELVVDKKQP ANHADANKAQ ALPETGEENP FIGTTVFGGL
500
501
SLALGAALLA GRRREL                                     
516
 

Show the unformatted sequence.

Checksums:
CRC64:C6FEFFF9E54BE1F0
MD5:8dd586e1e402a5fcce4fbf4f29f1d275

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
B 100 - 149 1DEE H 2803 - 2852 Show 3D Structure View in InterPro
6K3M H 3 - 52 Show 3D Structure View in InterPro
6K6A C 1803 - 1852 Show 3D Structure View in InterPro
101 - 149 5U3D C 4 - 52 Show 3D Structure View in InterPro
5U5F C 4 - 52 Show 3D Structure View in InterPro
5U5M C 4 - 52 Show 3D Structure View in InterPro
5U6A C 4 - 52 Show 3D Structure View in InterPro
6B9Y C 4 - 52 Show 3D Structure View in InterPro
6B9Z C 4 - 52 Show 3D Structure View in InterPro
6BAE C 4 - 52 Show 3D Structure View in InterPro
6BAH C 4 - 52 Show 3D Structure View in InterPro
6K64 C 2804 - 2852 Show 3D Structure View in InterPro
H 4 - 52 Show 3D Structure View in InterPro
102 - 145 6K68 E 5 - 48 Show 3D Structure View in InterPro
H 5 - 48 Show 3D Structure View in InterPro
I 5 - 48 Show 3D Structure View in InterPro
L 5 - 48 Show 3D Structure View in InterPro
103 - 149 1DEE G 1806 - 1852 Show 3D Structure View in InterPro
6K6A D 1806 - 1852 Show 3D Structure View in InterPro
213 - 265 1H0T A 2 - 54 Show 3D Structure View in InterPro
215 - 265 5U4Y D 102 - 152 Show 3D Structure View in InterPro
216 - 265 5U4Y C 103 - 152 Show 3D Structure View in InterPro
218 - 265 6K65 A 5 - 52 Show 3D Structure View in InterPro
271 - 323 6SOW A 2 - 54 Show 3D Structure View in InterPro
97 - 149 6K6B B 2 - 54 Show 3D Structure View in InterPro
Octapeptide 326 - 327 6SOW A 57 - 58 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;