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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: LAMP1_MOUSE (P11438)

Summary

This is the summary of UniProt entry LAMP1_MOUSE (P11438).

Description: Lysosome-associated membrane glycoprotein 1
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 406 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 2 25
disorder n/a 181 211
low_complexity n/a 189 211
Pfam Lamp 208 354
disorder n/a 246 247
transmembrane n/a 371 394
low_complexity n/a 375 395

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11438. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPGARRPL LLLLLAGLAH GASALFEVKN NGTTCIMASF SASFLTTYET
50
51
ANGSQIVNIS LPASAEVLKN GSSCGKENVS DPSLTITFGR GYLLTLNFTK
100
101
NTTRYSVQHM YFTYNLSDTE HFPNAISKEI YTMDSTTDIK ADINKAYRCV
150
151
SDIRVYMKNV TVVLRDATIQ AYLSSGNFSK EETHCTQDGP SPTTGPPSPS
200
201
PPLVPTNPTV SKYNVTGNNG TCLLASMALQ LNITYLKKDN KTVTRAFNIS
250
251
PNDTSSGSCG INLVTLKVEN KNRALELQFG MNASSSLFFL QGVRLNMTLP
300
301
DALVPTFSIS NHSLKALQAT VGNSYKCNTE EHIFVSKMLS LNVFSVQVQA
350
351
FKVDSDRFGS VEECVQDGNN MLIPIAVGGA LAGLVLIVLI AYLIGRKRSH
400
401
AGYQTI                                                
406
 

Show the unformatted sequence.

Checksums:
CRC64:C1BD373548BB9655
MD5:5566f494e83ee107e52cee2317514203

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Lamp 208 - 354 5GV0 A 208 - 354 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;