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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NUDT6_HUMAN (P53370)

Summary

This is the summary of UniProt entry NUDT6_HUMAN (P53370).

Description: Nucleoside diphosphate-linked moiety X motif 6 EC=3.6.1.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 316 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Nudix_hydro 46 129
low_complexity n/a 59 73
Pfam NUDIX 141 270

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P53370. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL
50
51
DRFGGISVRL ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL
100
101
QSRFIAPAAS LGFCFHHAES DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV
150
151
FDESTRKILV VQDRNKLKNM WKFPGGLSEP EEDIGDTAVR EVFEETGIKS
200
201
EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ EECLRCEWMD
250
251
LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL
300
301
YHKELPENYK TMKGID                                     
316
 

Show the unformatted sequence.

Checksums:
CRC64:41EC95893B52180A
MD5:b957033348f3e7e4eff46fd1fe3d48e0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NUDIX 143 - 270 3H95 A 143 - 270 Show 3D Structure View in InterPro
Nudix_hydro 46 - 129 3FXT A 46 - 129 Show 3D Structure View in InterPro
B 46 - 129 Show 3D Structure View in InterPro
C 46 - 129 Show 3D Structure View in InterPro
D 46 - 129 Show 3D Structure View in InterPro
E 46 - 129 Show 3D Structure View in InterPro
F 46 - 129 Show 3D Structure View in InterPro
G 46 - 129 Show 3D Structure View in InterPro
H 46 - 129 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;