Summary

This is the summary of UniProt entry RSME_BACSU (P54461).

Description:

Ribosomal RNA small subunit methyltransferase E EC=2.1.1.193

Source organism:

Bacillus subtilis (strain 168) (NCBI taxonomy ID 224308)

Length:

256 amino acids

Reference Proteome:

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source	Domain	Start	End	Gathering threshold (bits)		Score (bits)		E-value
Source	Domain	Start	End	Sequence	Domain	Sequence	Domain	Sequence	Domain
Pfam	PUA_4	21	68	23.9	23.9	61.3	59.3	2.4e-13	1e-12
Pfam	Methyltrans_RNA	75	246	23.9	23.9	189.7	189.2	9.1e-53	1.3e-52
low_complexity	n/a	119	128	n/a	n/a	n/a	n/a	n/a	n/a
disorder	n/a	131	132	n/a	n/a	n/a	n/a	n/a	n/a
disorder	n/a	213	215	n/a	n/a	n/a	n/a	n/a	n/a

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P54461. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:

1

MQRYFIELTK QQIEEAPTFS ITGEEVHHIV NVMRMNEGDQ IICCSQDGFE

50

51

AKCELQSVSK DKVSCLVIEW TNENRELPIK VYIASGLPKG DKLEWIIQKG

100

101

TELGAHAFIP FQAARSVVKL DDKKAKKKRE RWTKIAKEAA EQSYRNEVPR

150

151

VMDVHSFQQL LQRMQDFDKC VVAYEESSKQ GEISAFSAIV SSLPKGSSLL

200

201

IVFGPEGGLT EAEVERLTEQ DGVTCGLGPR ILRTETAPLY ALSAISYQTE

250

251

LLRGDQ

256

Show the unformatted sequence.

Checksums:

CRC64:AAE708FE4283157E

MD5:a8c61ca35168d1f41baa218042fc5115

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family	UniProt residues	PDB ID	PDB chain ID	PDB residues	View
Methyltrans_RNA	75 - 246	1VHK	A	75 - 246	Show 3D Structure View in InterPro
			B	75 - 246	Show 3D Structure View in InterPro
			C	75 - 246	Show 3D Structure View in InterPro
			D	75 - 246	Show 3D Structure View in InterPro
PUA_4	21 - 68	1VHK	A	21 - 68	Show 3D Structure View in InterPro
	21 - 68	1VHK	C	21 - 68	Show 3D Structure View in InterPro
	40 - 68	1VHK	B	40 - 68	Show 3D Structure View in InterPro
	43 - 51	1VHK	D	43 - 51	Show 3D Structure View in InterPro

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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

	Very High (pLDDT > 90)
	Confident (90 > pLDDT > 70)
	Low (70 > pLDDT > 50)
	Very Low (pLDDT < 50)

Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;

Protein: RSME_BACSU (P54461)