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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CERK1_MOUSE (Q8K4Q7)

Summary

This is the summary of UniProt entry CERK1_MOUSE (Q8K4Q7).

Description: Ceramide kinase
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 69 71
low_complexity n/a 86 99
Pfam DAGK_cat 132 274
Pfam CERK_C 286 531
low_complexity n/a 356 367
coiled_coil n/a 358 378
disorder n/a 466 472
disorder n/a 476 478

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8K4Q7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAMGAAEPL HSVLWVKRRR CAVSLEPARA LLRWWRSPEP GPSAPGADAR
50
51
SVLVSEIIAV EEKDDCEKHA SSGRWHKMEN PFAFTVHRVK RVRHHRWKWA
100
101
RVTFWSADEQ LCHLWLQTLR GLLESLTSRP KHLLVFINPF GGKGQGKRIY
150
151
EKTVAPLFTL ASITTEIIIT EHANQAKETL YEINTDSYDG IVCVGGDGMF
200
201
SEVLHGVIGR TQQSAGIDPN HPRAVLVPST LRIGIIPAGS TDCVCYSTVG
250
251
TNDAETSALH IIIGDSLAID VSSVHYHNTL LRYSVSLLGY GFYGDLIKDS
300
301
EKKRWMGLVR YDFSGLKTFL SHQYYEGTLS FLPAQHTVGS PRDNKPCRAG
350
351
CFVCRQSKQQ LEEEEKKALY GLENAEEMEE WQVTCGKFLA INATNMSCAC
400
401
PRSPGGLSPF AHLGDGSSDL ILIRKCSRFN FLRFLIRHTN QEDQFDFTFV
450
451
EVYRVKKFHF TSKHVEDEDN DSKEQEKQKF GKICKDRPSC TCSASRSSWN
500
501
CDGEVMHSPA IEVRVHCQLV RLFARGIEEE S                    
531
 

Show the unformatted sequence.

Checksums:
CRC64:C5A030D422E3AA10
MD5:1a0fb9ea6ddcc8ae8e86f315c0a91ac0

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;