Summary
This is the summary of UniProt entry TGFR2_CHICK (Q90999).
| Description: | TGF-beta receptor type-2 EC=2.7.11.30 |
| Source organism: |
Gallus gallus (Chicken)
(NCBI taxonomy ID
9031)
|
| Length: | 557 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 26 |
| low_complexity | n/a | 2 | 23 |
| Pfam | ecTbetaR2 | 39 | 149 |
| transmembrane | n/a | 156 | 178 |
| Pfam | PK_Tyr_Ser-Thr | 234 | 528 |
| disorder | n/a | 362 | 363 |
| disorder | n/a | 480 | 482 |
| disorder | n/a | 487 | 488 |
| disorder | n/a | 542 | 557 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q90999. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPPRLRPLLL RVSLWVLVGS SSPALLHDRS KENGLQLPRL CKFCDVKATT
50 51
CSNQDQCKSN CNITSICEKN NEVCAAVWRR NDENVTLETI CHDPQKRLYG
100 101
HMLDDSSSEQ CVMKEKKDDG GLMFMCSCTG EECNDVLIFS AIDPHKPEEK
150 151
DEISKVTIIS LVPLLVISVA VIVIFYAYRT HKKRKLNKAW EKNVKPKKHK
200 201
DCSDVCAIML DDDHSDISST CANNINHNTE LLPIELDIVV GKGRFAEVYK
250 251
AKLKQNTSEQ YETVAVKIFP YEEYASWKTE KDIFSDVNLK HENILQFLTA
300 301
EERKTDLGKQ YWLITAFHAR GNLQEYLTRH IISWEDLWKL GGSLARGIAH
350 351
LHSDHTPCGR PKTPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPSLSV
400 401
DDLANSGQVG TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR
450 451
CNGVGEVKEY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI PSSWLNHQGI
500 501
QMVCETLIEC WDHDPEARLT AQCVAERFSE FKHHDKLSGR SCSEEKIPED
550 551
GSVTTAK
557
Show the unformatted sequence. |
| Checksums: |
CRC64:0C578ABFAB357DF1
MD5:c3e0ac337a1720eda9a6dbd2e11cb904
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| ecTbetaR2 | 39 - 142 | 1KS6 | A | 4 - 107 | Show 3D Structure View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
