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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PADI3_HUMAN (Q9ULW8)

Summary

This is the summary of UniProt entry PADI3_HUMAN (Q9ULW8).

Description: Protein-arginine deiminase type-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 664 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PAD_N 1 113
disorder n/a 90 91
Pfam PAD_M 115 273
Pfam PAD 283 661

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9ULW8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLQRIVRVS LEHPTSAVCV AGVETLVDIY GSVPEGTEMF EVYGTPGVDI
50
51
YISPNMERGR ERADTRRWRF DATLEIIVVM NSPSNDLNDS HVQISYHSSH
100
101
EPLPLAYAVL YLTCVDISLD CDLNCEGRQD RNFVDKRQWV WGPSGYGGIL
150
151
LVNCDRDDPS CDVQDNCDQH VHCLQDLEDM SVMVLRTQGP AALFDDHKLV
200
201
LHTSSYDAKR AQVFHICGPE DVCEAYRHVL GQDKVSYEVP RLHGDEERFF
250
251
VEGLSFPDAG FTGLISFHVT LLDDSNEDFS ASPIFTDTVV FRVAPWIMTP
300
301
STLPPLEVYV CRVRNNTCFV DAVAELARKA GCKLTICPQA ENRNDRWIQD
350
351
EMELGYVQAP HKTLPVVFDS PRNGELQDFP YKRILGPDFG YVTREPRDRS
400
401
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSSGR RVTQVVRDFL
450
451
HAQKVQPPVE LFVDWLAVGH VDEFLSFVPA PDGKGFRMLL ASPGACFKLF
500
501
QEKQKCGHGR ALLFQGVVDD EQVKTISINQ VLSNKDLINY NKFVQSCIDW
550
551
NREVLKRELG LAECDIIDIP QLFKTERKKA TAFFPDLVNM LVLGKHLGIP
600
601
KPFGPIINGC CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
650
651
CRKPFSFKWW NMVP                                       
664
 

Show the unformatted sequence.

Checksums:
CRC64:90C22A50BF6FD480
MD5:1a5b134173e04a866638ab73a1a2d6ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PAD 283 - 661 6CE1 A 283 - 661 Show 3D Structure View in InterPro
7D4Y A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
7D56 A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
C 283 - 661 Show 3D Structure View in InterPro
7D5R A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
7D5V A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
7D8N A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
7DAN A 283 - 661 Show 3D Structure View in InterPro
B 283 - 661 Show 3D Structure View in InterPro
C 283 - 661 Show 3D Structure View in InterPro
PAD_M 115 - 273 6CE1 A 115 - 273 Show 3D Structure View in InterPro
7D4Y A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
7D56 A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
C 115 - 273 Show 3D Structure View in InterPro
7D5R A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
7D5V A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
7D8N A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
7DAN A 115 - 273 Show 3D Structure View in InterPro
B 115 - 273 Show 3D Structure View in InterPro
C 115 - 273 Show 3D Structure View in InterPro
PAD_N 1 - 113 7D4Y B 1 - 113 Show 3D Structure View in InterPro
7D56 A 1 - 113 Show 3D Structure View in InterPro
B 1 - 113 Show 3D Structure View in InterPro
C 1 - 113 Show 3D Structure View in InterPro
7DAN A 1 - 113 Show 3D Structure View in InterPro
B 1 - 113 Show 3D Structure View in InterPro
C 1 - 113 Show 3D Structure View in InterPro
2 - 113 6CE1 A 2 - 113 Show 3D Structure View in InterPro
7D4Y A 2 - 113 Show 3D Structure View in InterPro
7D5V A 2 - 113 Show 3D Structure View in InterPro
B 2 - 113 Show 3D Structure View in InterPro
7D8N A 2 - 113 Show 3D Structure View in InterPro
B 2 - 113 Show 3D Structure View in InterPro
3 - 113 7D5R A 3 - 113 Show 3D Structure View in InterPro
B 3 - 113 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;