Summary
This is the summary of UniProt entry PADI4_MOUSE (Q9Z183).
| Description: | Protein-arginine deiminase type-4 |
| Source organism: |
Mus musculus (Mouse)
(NCBI taxonomy ID
10090)
|
| Length: | 666 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| Pfam | PAD_N | 1 | 111 |
| disorder | n/a | 4 | 6 |
| disorder | n/a | 61 | 66 |
| disorder | n/a | 78 | 82 |
| disorder | n/a | 91 | 95 |
| Pfam | PAD_M | 113 | 273 |
| disorder | n/a | 124 | 139 |
| disorder | n/a | 152 | 153 |
| disorder | n/a | 163 | 169 |
| disorder | n/a | 177 | 182 |
| Pfam | PAD | 283 | 663 |
| low_complexity | n/a | 320 | 335 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Z183. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAQGAVIHVA PEQPTHAVCV VGTATPLDVR GSAPKGYTTF GITASPGVIV
50 51
DVIHGPPVKK STMGASKWPL DPELEVTLQV KAASSRTDDE KVRVSYYGPK
100 101
TSPVQALIYI TGVELSLSAD VTRTGRVKPA QAGKDQSTWT WGPGGRGAIL
150 151
LVNCDKEDPQ ASGMDFEDDK ILDNKDLQDM SPMTLSTKTP KDFFEKYQLV
200 201
LEVPKAKMNR VRVFRATRGK LPSRYKVALG PQQFSYCLEL PGGQHSTDFY
250 251
VEGLAFPDAD FKGLIPLTIS LLDKSNPELP EALVFQDSVT FRVAPWIMTP
300 301
NTQPPQEVYV CRVSDNEDFL KSLATLTKKA KCKLTVCPEE ENIDDQWMQD
350 351
EMEIGYIQAP HKTLPVVFDS PRDRGLKDFP VKRVMGPNFG YVTRKLYMSE
400 401
LTGLDAFGNL EVSPPVTVRG KEYPLGRILI GNSGYSSSES RDMHQALQDF
450 451
LSAQQVQAPV RLFSDWLFVG HVDEFLSFVP ARDKQGFRLL LSSPRACYQL
500 501
FQELQSQGHG EATLFEGLKR KRQTINEILS NKKLRDQNAY VESCIDWNRA
550 551
VLKRELGLAE GDIIDIPQLF KLAGNSRGNS KAQAFFPNMV NMLVLGKYLG
600 601
IPKPFGPIID GHCCLEEEVR SHLEPLGLHC TFINDFYTYH VYNGEVHCGT
650 651
NVRRKPFTFK WWHMVP
666
Show the unformatted sequence. |
| Checksums: |
CRC64:F25B7A7B69285C32
MD5:127d1b0f67de6a73ef26cc973e52d4a7
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| PAD_N | 93 - 105 | 6MKD | D | -26 - -14 | Show 3D Structure View in InterPro |
| 6MKR | D | -26 - -14 | Show 3D Structure View in InterPro | ||
| 6MNM | D | -26 - -14 | Show 3D Structure View in InterPro | ||
| 6MNN | D | -26 - -14 | Show 3D Structure View in InterPro | ||
| 6MNO | D | -26 - -14 | Show 3D Structure View in InterPro | ||
| 94 - 105 | 6MNG | D | -25 - -14 | Show 3D Structure View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
