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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SV2C_RAT (Q9Z2I6)

Summary

This is the summary of UniProt entry SV2C_RAT (Q9Z2I6).

Description: Synaptic vesicle glycoprotein 2C
Source organism: Rattus norvegicus (Rat) (NCBI taxonomy ID 10116)
Length: 727 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 18
coiled_coil n/a 20 40
disorder n/a 21 97
low_complexity n/a 51 57
disorder n/a 99 129
Pfam Sugar_tr 117 428
low_complexity n/a 119 135
coiled_coil n/a 120 140
transmembrane n/a 152 177
transmembrane n/a 189 208
transmembrane n/a 220 237
transmembrane n/a 243 267
transmembrane n/a 279 301
transmembrane n/a 321 340
transmembrane n/a 436 454
Pfam Pentapeptide_4 496 573
Pfam MFS_1 563 725
transmembrane n/a 580 603
transmembrane n/a 610 629
transmembrane n/a 635 659
transmembrane n/a 671 692
transmembrane n/a 698 718
low_complexity n/a 707 716

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9Z2I6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
50
51
DEDDDDDYYP PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN
100
101
QGKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
150
151
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
200
201
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLLCRLL
250
251
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
300
301
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
350
351
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
400
401
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL
450
451
SVWFPDVIKH LQSDEYALLT RNVQKDKYAN FSINFTMENQ VHTGMEYDNG
500
501
RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT LFENTDFEPY
550
551
KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
600
601
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
650
651
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP
700
701
ILLASTVLVC GGLVGLRLPD TRTQVLM                         
727
 

Show the unformatted sequence.

Checksums:
CRC64:4C154C69341D8DB7
MD5:4f450fa291b42b5e63943a985afb6c68

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MFS_1 563 - 564 5JMC H 563 - 564 Show 3D Structure View in InterPro
563 - 566 5JMC B 563 - 566 Show 3D Structure View in InterPro
563 - 567 5JMC D 563 - 567 Show 3D Structure View in InterPro
F 563 - 567 Show 3D Structure View in InterPro
Pentapeptide_4 496 - 564 5JMC H 496 - 564 Show 3D Structure View in InterPro
496 - 566 5JMC B 496 - 566 Show 3D Structure View in InterPro
496 - 567 5JMC D 496 - 567 Show 3D Structure View in InterPro
F 496 - 567 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;